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A New Neutrophil Subset Suppresses Immunity Response in CRCLMA New Neutrophil Subset Suppresses Immunity Response in CRCLM

A new study sheds light on the role of neutrophils in colorectal cancer liver metastasis. Using single-cell RNA sequencing and multiplex imaging, researchers identified a distinct TAN1_LGALS3 neutrophil population enriched in liver metastases. Characterized by high CXCR4 expression, these cells contribute to an angiogenic and immunosuppressive microenvironment that may support metastatic progression.

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   A simple facial photograph may hold clues to cancer survivalA simple facial photograph may hold clues to cancer survival
 
FAHR-Face leverages AI to extract prognostic data from facial photographs, potentially transforming cancer survival predictions and clinical decision-making.
 
   Discovery of new bacteria opens fresh avenues for prostate cancer researchDiscovery of new bacteria opens fresh avenues for prostate cancer research
 
University of East Anglia researchers have discovered the genetic blueprints of 18 new bacterial species collected from prostate cancer patients.
 
 Decipher tissue-based molecular test helps personalize high-risk prostate cancer treatment
 
Decipher tissue-based molecular test helps personalize high-risk prostate cancer treatmentProstate cancer is the most common cancer in men – in 2013, it affected more than one million men across the world.
 
 
 Targeted drug extends survival across diverse pancreatic cancer patient groups
 
Targeted drug extends survival across diverse pancreatic cancer patient groupsA new analysis of a phase 3 clinical trial found that the targeted drug daraxonrasib improved survival compared with standard chemotherapy across multiple groups of patients with advanced pancreatic cancer, including those with different RAS mutations and those without an identified RAS mutation.
 
 
 CT scans reveal body composition changes preceding pancreatic cancer diagnosis
 
CT scans reveal body composition changes preceding pancreatic cancer diagnosisPeople who develop pancreatic cancer experience measurable changes in body composition years before diagnosis that differ from those seen in similar individuals without cancer, according to a Mayo Clinic study led by former Mayo Clinic research fellow, Aleksander Bogdanski and published in Pancreatology.
 
 
 Study reveals how cancer cells survive chemotherapy in a zombie-like state
 
Study reveals how cancer cells survive chemotherapy in a zombie-like stateScientists at Trinity College Dublin have made an important breakthrough in understanding how cancer cells can evade the cell-killing effects of chemotherapy and enter a "zombie-like state", called premature senescence, that can attract the wound healing properties of the immune system.
 
 
 Doctors explain why breast cancer screening should start at age 40
 
Doctors explain why breast cancer screening should start at age 40Advances in breast cancer screening and treatment are helping doctors detect the disease earlier, tailor therapies to individual patients and, in some cases, spare women from unnecessary chemotherapy, radiation and surgery.
 
 
 Liquid biopsy reliably detects early-stage lung cancer recurrence risk
 
Liquid biopsy reliably detects early-stage lung cancer recurrence riskDespite advances in early-stage lung cancer treatment, a significant number of patients experience disease recurrence after surgery or initial therapy.
 
 
 Researchers identify molecular target to improve pancreatic cancer treatment
 
Researchers identify molecular target to improve pancreatic cancer treatmentPancreatic cancer is one of the most aggressive and difficult-to-treat cancers. One reason for its resistance to therapy is the dense tissue surrounding the tumor, which acts as a protective barrier and suppresses the immune response.
 
 
 Supercomputer helps design more reliable AI for breast cancer diagnosis
 
Supercomputer helps design more reliable AI for breast cancer diagnosisWhile AI offers the ability to improve human experts' ability to diagnose and treat diseases like breast cancer, well-publicized errors across the broader AI field are cause for concern.
 
 
 ESMO introduces new set of principles to strengthen the communication of cancer research
 
ESMO introduces new set of principles to strengthen the communication of cancer researchThe new 'ESMO Principles for Humanising Scientific Reporting' aim to strengthen the communication of oncology research, connect scientific evidence with patient relevance, and support a more patient-centered approach to cancer research communication.
 
 
 ESMO updates precision oncology framework to improve targeted therapies
 
ESMO updates precision oncology framework to improve targeted therapiesESMO has published version 2 of the ESMO Scale for Clinical Actionability of molecular Targets (ESCAT), a major update to the internationally recognized precision oncology framework that helps oncologists assess the clinical relevance of molecular alterations and match patients with the most appropriate targeted therapies.
 
 
 ECOG-ACRIN opens trial testing ivonescimab for aggressive bile duct cancer
 
ECOG-ACRIN opens trial testing ivonescimab for aggressive bile duct cancerThe ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) announced today that it will open a randomized, registration-enabling phase 2/3 clinical trial to evaluate ivonescimab combined with chemotherapy as first-line treatment for patients with advanced biliary tract cancer (BTC).
 
 
 Glucose priming may improve tumor targeting for chemotherapy nanocarriers
 
Glucose priming may improve tumor targeting for chemotherapy nanocarriersChemotherapy selectivity is limited by systemic toxicity. pH‑sensitive nanocarriers exploit tumor acidity as a release trigger but respond passively to a modest, heterogeneous gradient.
 
 
 Long-Read Nanopore Sequencing Resolves Unexplained Tumor Mutations
 
Long-Read Nanopore Sequencing Resolves Unexplained Tumor MutationsMichigan's Oncology Sequencing Program, or MiOncoSeq, was the first of its kind in the nation to sequence patient tumors.
 
 

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