Blood protein clocks flag higher risks of death and chronic disease
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 Faster biological aging may help explain rising cancer rates in younger adultsFaster biological aging may help explain rising cancer rates in younger adults
 
A new study found that later birth cohorts showed greater biological aging, measured by systemic age-gap clocks. Greater biological aging was associated with higher early-onset solid cancer risk, especially lung, gastrointestinal, and uterine cancers.
 
 
 Blood protein clocks flag higher risks of death and chronic diseaseBlood protein clocks flag higher risks of death and chronic disease
 
Proteomic age clocks applied to two European cohorts linked faster biological aging with smoking, alcohol use, physical inactivity, all-cause mortality, cardiovascular disease, dementia, and several cancers. The Global proteomic clock predicted mortality as well as established lifestyle risk factors, while organ-specific clocks showed stronger links with related cancers of the kidney, lung, and stomach.
 
   Flavonoid-rich foods may blunt breast cancer risk tied to geneticsFlavonoid-rich foods may blunt breast cancer risk tied to genetics
 
Higher flavodiet scores were associated with lower breast cancer risk among 93,271 UK Biobank females followed for a median of 11.8 years. The inverse association was particularly evident in women with high genetic risk, but the observational study cannot prove causation.
 
   First-in-human trial tests safer T-cell therapy for pediatric brain cancersFirst-in-human trial tests safer T-cell therapy for pediatric brain cancers
 
Researchers report encouraging early results from a first-in-human clinical trial led by Children's National using a new T-cell immunotherapy for children and young adults with some of the deadliest brain tumors, including diffuse intrinsic pontine glioma (DIPG) and relapsed central nervous system (CNS) tumors.
 
   Multi-cancer early detection: How blood tests are transforming cancer screeningMulti-cancer early detection: How blood tests are transforming cancer screening
 
Advancements in MCED technology enable simultaneous screening for various cancers, improving early detection and addressing critical healthcare gaps.
 
 CAR-T cell therapy shows potential to eliminate aggressive glioblastoma
 
CAR-T cell therapy shows potential to eliminate aggressive glioblastomaA study led by a researcher based at King's College London and McMaster University in Canada reveals how CAR-T cell therapy, a treatment that engineers a patient's own immune cells to recognize and attack cancer, could be used to treat glioblastoma.
 
 
 German study identifies therapeutic Achilles' heel for advanced colorectal cancer
 
German study identifies therapeutic Achilles' heel for advanced colorectal cancerA team led by researchers from the German Cancer Research Center (DKFZ) and the HI-STEM* Stem Cell Institute has discovered a promising new approach to treating advanced colorectal cancer.
 
 
 Cancer's biggest treatment challenge may be getting solved 250 miles above Earth
 
Cancer's biggest treatment challenge may be getting solved 250 miles above EarthFor more than two decades, precision oncology has been promoted as the future of cancer treatment, matching therapies to the unique biology of a patient's tumor.
 
 
 New bacterial enzyme blueprint could accelerate cancer treatment development
 
New bacterial enzyme blueprint could accelerate cancer treatment developmentA team of researchers at the University of Warwick and Monash University has solved a puzzle that's stumped drug developers for decades: how bacteria naturally create multiple versions of powerful cancer therapies.
 
 
 Japanese study links inherited genetic variants to multiple lung cancers
 
Japanese study links inherited genetic variants to multiple lung cancersLung cancer remains the leading cause of cancer-related deaths worldwide and is generally thought to arise from mutations acquired over a lifetime through environmental exposures.
 
 
 Targeted therapy doubles progression-free survival in rare bile duct cancer
 
Results of the ongoing eNRGy trial, a single-arm, multicenter, global phase 2 clinical trial evaluating zenocutuzumab in solid tumors positive for Neuregulin 1 (NRG1) gene fusions, reported manageable side effects and clinically meaningful efficacy – including a near doubling of progression-free survival compared to expectations with standard of care – in previously treated patients with advanced NRG1-positive cholangiocarcinoma.
 
 
 Women in high-deprivation areas face barriers to digital breast tomosynthesis screening
 
New research has found that digital breast tomosynthesis (DBT) availability at breast imaging facilities is similar across low- and high-deprivation areas, but facilities in low-deprivation areas are significantly more likely to offer weekend appointments, which may impact access for traditionally underserved populations.
 
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