Oncology - Cancer-related DNA changes may appear in blood years before diagnosis
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Tumor-Derived Exosomal TAGLN2 Promotes Metastasis in Gastric CancerTumor-Derived Exosomal TAGLN2 Promotes Metastasis in Gastric Cancer

Recent research suggests that tumor cells communicate with surrounding tissues long before metastatic lesions become established, creating conditions that favor tumor dissemination and growth. One of important mediators of this communication are tumor-derived exosomes (TEX). Multiplex imaging combined with quantitative analysis shows that TAGLN2 contained in TEX might be a metastatic trigger in gastric cancer.

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   Cancer-related DNA changes may appear in blood years before diagnosisCancer-related DNA changes may appear in blood years before diagnosis
 
Researchers found that genome-wide plasma cfDNA methylation profiles collected before diagnosis contained early molecular signatures associated with future prostate and breast cancer, with prostate silencer methylation providing the stronger risk stratification.
 
   Why are more younger adults in the Eastern Mediterranean facing colorectal cancer?Why are more younger adults in the Eastern Mediterranean facing colorectal cancer?
 
A 22-country analysis of modeled GLOBOCAN 2022 data found 15,381 early-onset colorectal cancer cases and 6,965 related deaths across the WHO Eastern Mediterranean Region, with substantial differences between countries and comparatively high mortality.
 
 Researchers find how prostate tumors reshape the immune microenvironment
 
Researchers find how prostate tumors reshape the immune microenvironmentResearchers at The University of Texas MD Anderson Cancer Center have identified a previously unknown pathway that prostate tumors leverage to suppress the immune system by reshaping the tumor microenvironment to resist treatment.
 
 
 MIT biologists discover cellular pathway that triggers colon cancer spread
 
MIT biologists discover cellular pathway that triggers colon cancer spreadMost colon cancer deaths are caused by the spread of tumor cells beyond the colon, usually to the liver. In a new study, MIT biologists identified a cellular pathway necessary for colorectal cancer metastasis.
 
 
 City of Hope develops adaptive plug-and-play CAR T technology to attack tumors
 
City of Hope develops adaptive plug-and-play CAR T technology to attack tumorsResearchers from City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the country, have developed a new "plug-and-play" technology that adds engineered molecules to chimeric antigen receptor (CAR) T cells after treatment, allowing scientists to better control the cells and redirect them to attack different types of cancer.
 
 
 Review highlights emerging treatments for glioblastoma multiforme
 
Review highlights emerging treatments for glioblastoma multiformeA new research perspective was published in Volume 13 of Oncoscience on September 17, 2026, titled "Emerging pharmacological agents for glioblastoma multiforme: An update on active clinical trials (2025–2026)."
 
 
 UCLA researchers present new radiation advances at ASTRO 2026
 
UCLA researchers present new radiation advances at ASTRO 2026Physicians and scientists from the UCLA Health Jonsson Comprehensive Cancer Center will share new research and clinical trial findings at the 2026 American Society for Radiation Oncology (ASTRO) Annual Meeting, including studies on new treatment approaches for prostate, bile duct and head and neck cancers, personalized radiation therapy based on genetic risk, and advances in targeted radiation and radioligand therapy designed to improve cancer...
 
 
 Long-term endocrine therapy adherence remains low after breast cancer surgery
 
Long-term endocrine therapy adherence remains low after breast cancer surgeryMany patients with early-stage breast cancer do not consistently maintain the long-term hormone therapy prescribed after lumpectomy, a large U.S. insurance claims analysis indicates.
 
 
 Ultra-low-dose radiation therapy eases painful bone lesions in multiple myeloma
 
Ultra-low-dose radiation therapy eases painful bone lesions in multiple myelomaA short course of ultra-low-dose radiation therapy relieved painful bone lesions from multiple myeloma for most patients in a multi-institutional phase 2 clinical trial.
 
 

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