Oncology - Researchers identify nervous system components driving gastrointestinal cancer growth
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Integrative Multiomics Approach Unveils Systemic Dysfunction in Colorectal Cancer (CRC)Integrative Multiomics Approach Unveils Systemic Dysfunction in Colorectal Cancer (CRC)

A recent study identified distinct immunotypes within the CRC macroenvironment, revealing altered immune cell compositions by combining CyTOF, scRNAseq and mIF. The findings indicate that PD1+CD69+CD8+ T cells in blood can potentially predict tertiary lymphoid structure presence. The team used TissueFAXS slide scanner and StrataQuest software to image and analyze mIF-stained tumor sections.

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   Researchers identify nervous system components driving gastrointestinal cancer growthResearchers identify nervous system components driving gastrointestinal cancer growth
 
Australian researchers have identified two nervous system components that drive tumor growth in gastrointestinal cancers, creating promising new avenues for treatment with existing approved therapies.
 
   Antibody discovery could provide new treatment options for aggressive breast cancersAntibody discovery could provide new treatment options for aggressive breast cancers
 
A new potential antibody therapy strategy which restricts the growth of treatment-resistant breast cancers has been developed by scientists.
 
 Drug shows striking success in treating children with multi-metastatic Ewing sarcoma
 
Drug shows striking success in treating children with multi-metastatic Ewing sarcomaEwing sarcoma is one of the most common bone cancers seen in children, and if it spreads, it can be deadly. One study found that under a quarter of children with multi-metastatic Ewing sarcoma survived five years after their diagnosis.
 
 
 A new way to monitor chemotherapy drug behavior inside cells
 
A new way to monitor chemotherapy drug behavior inside cellsScientists have made incredible progress in developing cancer therapies that help patients across cancer types.
 
 
 Novel combination therapy shows promise for advanced neuroendocrine tumors
 
Novel combination therapy shows promise for advanced neuroendocrine tumorsA novel combination therapy pairing a DNA-synthesis inhibitor with a targeted radiopharmaceutical may improve outcomes for patients with advanced neuroendocrine tumors, according to new clinical trial data presented this week at the European Society for Medical Oncology (ESMO) Congress 2025.
 
 
 Breakthrough combo therapy lowers death risk in recurrent prostate cancer
 
Breakthrough combo therapy lowers death risk in recurrent prostate cancerMen whose prostate cancer returns after surgery or radiation therapy may now benefit from a new drug combination shown in clinical trials to cut the risk of death by more than 40%.
 
 
 New type of immunotherapy could change the treatment plan for triple-negative breast cancer
 
New type of immunotherapy could change the treatment plan for triple-negative breast cancerTriple-negative breast cancer is one of the most aggressive cancers. The name tells the story: It lacks the three main targets that make other types of breast cancers more treatable with powerful therapies.
 
 
 New drug combination shows promise in treating colorectal cancer
 
New drug combination shows promise in treating colorectal cancerColorectal cancer is one of the most common tumors among people over the age of 50. Although it is known to develop from small lesions or polyps, its exact causes are unknown — only a few risk factors are known — and it is usually treated with surgery, chemotherapy and radiotherapy, or biological therapies.
 
 
 Oral targeted therapy shrinks tumors in over 70% of patients with HER2-mutant NSCLC
 
Oral targeted therapy shrinks tumors in over 70% of patients with HER2-mutant NSCLCThe oral targeted therapy sevabertinib led to tumor reduction and manageable side effects in patients with HER2-mutant non-small cell lung cancer (NSCLC), according to data from a trial led by researchers at The University of Texas MD Anderson Cancer Center.
 
 

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