| Antibodies - Accelerating Nanobody Production using Polyclonal Anti-VHH Antibodies |
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The latest antibodies news from News Medical |
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 | | |  ADA/PK Development and Custom Antibody Lab Services
An idiotope is the unique set of antigenic determinants (epitopes) of the variable portion of an antibody. An anti-idiotypic (Anti-ID) antibody binds to the idiotope of another antibody, usually an antibody drug, which makes it a very powerful tool for antibody drug development, especially for immunogenicity and PK/PD analysis. ACROBiosystems has developed a series of high-affinity anti-idiotypic antibodies and ADA/PK services along with many other custom antibody lab services.
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| | | | |  Nanobodies are antibodies with a single variable domain located on a heavy chain, also known as VHH antibodies. Nanobodies are often seen as an alternative to conventional antibodies, and have significant differences in both production and use that influence their suitability. | | | | |  Human blood samples can be used to produce antibodies against an antigen of interest. Since the blood contains antigen-presenting immune cells, antibody identification only requires a binding assay to identify the cells presenting suitable antibodies. However, this selects for “early” antibodies, which in the organism would undergo maturation by multiple rounds of mutation and selection, leading to antibodies that are more effective in antigen-binding. | | | | |  In most clinical applications, the monoclonal antibodies (mAbs) used are of murine origin; however, the small spleen of the mouse is limited in its ability to generate antibodies. Also, the mice used for laboratory experiments are usually inbred in a controlled environment, further restricting their ability to demonstrate diverse immune responses. | | | | |  Research on therapies against the Human Immunodeficiency Virus (HIV) has repeatedly demonstrated the potential of broadly neutralizing antibodies (bn-Abs) as successful therapeutic agents. Injection of such antibodies leads to a decrease in viral concentrations in blood. However, repeated injections are necessary to prevent the recovery of the virus. | |
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