Antibodies - New Insights Into Antibody Glycans may Advance Tuberculosis Prevention
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Introducing the Clara™ System for Clarity in Biologics PreparationsIntroducing the Clara™ System for Clarity in Biologics Preparations

The complexity of biological molecules introduces a number of challenges for the development of monoclonal antibodies (MABs). The antibody discovery and protein engineering pathway for the design of MABs for therapeutic applications is particularly demanding. The Clara™ filter system provides solution for mid-volume cell culture during scale up allowing fast and simple cell clarification and protein purification of up to 50 mL cultured cells per well in a 6 well format.

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   New Insights Into Antibody Glycans may Advance Tuberculosis PreventionNew Insights Into Antibody Glycans may Advance Tuberculosis Prevention
 
Certain antibodies inhibit Mycobacterium tuberculosis, the cause of tuberculosis (TB), the infectious disease that claims the most lives worldwide, a study led by UT Southwestern Medical Center researchers found.
 
   Antibody feedback reshapes B cell selection during immune responseAntibody feedback reshapes B cell selection during immune response
 
A collaborative study published in Immunity from the Batista Lab and Liu Lab at the Ragon Institute, together with the Schief Lab at Scripps Research Institute, has uncovered a previously unrecognized mechanism that shapes how immune cells are selected during an immune response.
 
 Novel antibody 007 targets the elusive HIV envelope epitope
 
Novel antibody 007 targets the elusive HIV envelope epitopeHIV-1 can be neutralized by antibodies which bind to vulnerable structures on the virus surface. One such vulnerable site is the so-called V3 glycan site of the viral envelope protein.
 
 
 Gut microbial butyrate enhances mucosal vaccine antibody responses
 
Gut microbial butyrate enhances mucosal vaccine antibody responsesA research team from POSTECH and ImmunoBiome in Korea, led by Professor Sin-Hyeog Im, has uncovered a new mechanism showing how butyrate-a short-chain fatty acid produced by gut commensal bacteria-enhances T follicular helper (Tfh) cell activity to promote antibody production and strengthen mucosal vaccine efficacy.
 
 
 Cancer-fighting antibodies may trigger autoimmune brain disorders
 
Cancer-fighting antibodies may trigger autoimmune brain disordersConsider two seemingly unrelated medical puzzles. First: Every day, our bodies produce hundreds of billions of new cells, many of which are mutated.
 
 
 Maternal antibodies protect newborns from severe E. coli infections, study finds
 
Maternal antibodies protect newborns from severe E. coli infections, study findsA multi-center study led by researchers at Cincinnati Children's sheds surprising new light on why some newborns become severely ill from Escherichia coli infection, but others do not.
 
 

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