Drug Discovery and Production - Uncovering the Structure of HIV Integrase to Inform Drug Discovery
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  May 2, 2019  
  Drug Discovery and Production  
  The latest drug discovery news from News Medical  
 Monitoring Ambient Environmental ConditionsMonitoring Ambient Environmental Conditions
 
For numerous industries and applications, the ability to monitor ambient environmental conditions, including temperature, pressure, humidity and light levels, is a crucial necessity. Variations in ambient conditions can have a negative impact on the equipment held in life science labs, which is often worth millions of dollars.
 
   Pipettes of the Future: Automation for AccelerationPipettes of the Future: Automation for Acceleration
 
The successful development of current life-saving therapeutics often starts with the identification of new drug targets using sophisticated instrumentation, bioinformatics, and highly valuable human tissue samples. Hypotheses are rigorously tested, experimental conditions tightly controlled, and increasingly complex data sets meticulously analyzed.
 
   Uncovering the Structure of HIV Integrase to Inform Drug DiscoveryUncovering the Structure of HIV Integrase to Inform Drug Discovery
 
In this interview Dr Kushol Gupta, Research Assistant Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania talks to News-Medical and Life Sciences about the importance of light scattering techniques for investigating structure and mechanism of action in his ongoing research into HIV integrase and the development of HIV therapeutics.
 
 New drug minimizes damage after a heart attack by 60 percent
 
New drug minimizes damage after a heart attack by 60 percentDomainex is pleased to announce that a team of its scientists, working in close partnership with Professor Michael Schneider and his team at Imperial College, have found a potential new drug for treating the heart damage caused by a heart attack by targeting the way the heart reacts to stress. The research was published in the journal, Cell Stem Cell, and was part-funded by the British Heart Foundation (BHF).
 
 
 Cobots versus Robots in the Life Sciences Industry
 
Cobots versus Robots in the Life Sciences IndustryCobots, or collaborative robots, were designed to work alongside and share workspace with humans, whereas robots take over manual tasks by themselves.
 
 
 Animal Cell Line Authentication by DNA Barcoding
 
Animal Cell Line Authentication by DNA BarcodingCell lines are an invaluable research tool. However, while they are easy to grow and manipulate, the risk of contamination is high. This can have a detrimental effect on research results, thus, there is a need for new techniques that can ensure sterility in cell culture. DNA barcoding - the identification of a specific cell line using a genetic sequence - is just one of the solutions that has been proposed to solve this issue.
 
 
 ELISA versus Mass Spectrometry for the Detection of HCPs
 
ELISA versus Mass Spectrometry for the Detection of HCPsHost cell proteins, or HCPs, are native proteins inside a cell that is being used for recombinant protein expression. HCPs can contaminate biopharmaceutical products, which can in turn reduce the effectiveness of the drug or cause patients to have adverse reactions. Their effective detection and quantification can be done using both ELISA and mass spectrometry.
 
 
 Alcohol, Cannabis and Other Drugs: A Pharmacological Evaluation
 
Alcohol, Cannabis and Other Drugs: A Pharmacological EvaluationUnderstanding the interactions between alcohol and cannabis can provide researchers, clinicians and other HCPs with important information on the severity of their side effects.
 
 
 Hundreds of new anti-cancer drug targets identified using CRISPR
 
Hundreds of new anti-cancer drug targets identified using CRISPRA team of scientists from the Wellcome Sanger Institute have identified the genes that are essential for the survival of thirty types of cancer cells.