Drug Discovery and Production - Understanding Lead Optimization
Can't see this email? View it online
   
  July 2, 2019  
  Drug Discovery and Production  
  The latest drug discovery news from News Medical  
 

#ALT# Visual observation of phase transformations in pharmaceutical solids

Studying phase transformations in pharmaceutical solids during vapor sorption is important in understanding their physicochemical properties. The new video microscope for the Hiden Isochema IGAsorp DVS analyzer allows high resolution image collection and TGA measurements up to 350 °C. This option facilitates the study of phase changes including crystallization, hydration and deliquescence.

Read Full Article Here
 
   Understanding Lead OptimizationUnderstanding Lead Optimization
 
The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization.
 
   Transmission Raman Spectroscopy Advantages and LimitationsTransmission Raman Spectroscopy Advantages and Limitations
 
Transmission Raman Spectroscopy is a variation of transmission Raman spectroscopy that is often used to probe the bulk properties of samples that scatter diffusely. It is particularly useful for the analysis of materials that are opaque or turbid.
 
 Protein Interaction Studies Using Microfluidics
 
Protein Interaction Studies Using MicrofluidicsMicrofluidics is an upcoming technology that has been used in many areas of chemical and biological research. One valuable application of this technique is in studying protein-protein interactions in cell biology. This is essential in allowing insights into cell signaling and gene regulatory pathways for further understanding of biological processes.
 
 
 Current and Future Applications of Rabbit Monoclonal Antibodies
 
Current and Future Applications of Rabbit Monoclonal AntibodiesIn most clinical applications, the monoclonal antibodies (mAbs) used are of murine origin; however, the small spleen of the mouse is limited in its ability to generate antibodies. Also, the mice used for laboratory experiments are usually inbred in a controlled environment, further restricting their ability to demonstrate diverse immune responses.
 
 
 

#ALT#

Why are you seeing this?

 
 
 Cannabis ingredient shows promise as potential antibiotic for superbugs
 
Cannabis ingredient shows promise as potential antibiotic for superbugsResearchers at the University of Queensland have found that a topical formulation containing cannabidiol (CBD) is effective at killing bacterial skin infections and could form the basis of a new drug.
 
 
 Are fruit fly 'avatars' the next step in personalized medicine?
 
Are fruit fly 'avatars' the next step in personalized medicine?Researchers have created fruit fly “avatars” that have helped to guide treatment for a man who had terminal colon cancer. The team genetically engineered flies that had the same mutations as the man’s tumor and then tested different drug combinations to see which ones kept the flies alive. Doctors eventually settled on a drug combination that was the most effective and administered it to the man.
 
 
 Short Hairpin RNA (shRNA) Interference: Therapeutic Applications
 
Short Hairpin RNA (shRNA) Interference: Therapeutic ApplicationsRNA interference is a biological process that has evolved with the evolution of mammals and plays an important role in transient and long-term blocking of protein expression. Short Hairpin RNA (shRNA) interference has many therapeutic applications, and research is still ongoing into new areas of focus.
 
 
 New technology harnesses bacterial jumping genes for precise DNA integration
 
New technology harnesses bacterial jumping genes for precise DNA integrationA new discovery by researchers at Columbia University Vagelos College of Physicians and Surgeons could fix one of the major shortcomings of current gene-editing tools, including CRISPR, and offer a powerful new approach for genetic engineering and gene therapy.