Quantitative cellular analysis of COVID-19-infected astrocytes reveals a more central role of astrocytes in NeuroCOVID-19 and the interruptive impact of SARS-CoV-2 on astrocyte homeostasis capabilities, reframing astrocytes as active protagonists.
The advent of mRNA vaccines against SARS-CoV-2 in 2020 changed the course of the COVID-19 pandemic. Now, the Nobel-prize–winning technology is being adapted to fight cancer, with mRNA vaccines in clinical trials for melanoma, small cell lung cancer and bladder cancer, among others, opening the door to new ways of preventing and treating the disease.
This study examined mitochondrial and nuclear-encoded mitochondrial DNA methylation in Indian patients with severe COVID-19 and found region-specific differential methylation linked to disease severity. Pathway analyses and protein assays implicated disrupted mitochondrial metabolism and dynamics, suggesting a role for mitochondrial epigenetic regulation in COVID-19 pathophysiology.
Scientists have identified molecular and structural changes in taste buds that may explain why a small subset of people experience long-term taste loss after COVID-19 infection.
This study shows that SARS-CoV-2 infection and vaccination generate strong, highly specific spike-binding immune responses with only modest effects on immunity to endemic common cold coronaviruses. Pre-existing coronavirus immunity patterns remain largely intact, indicating that SARS-CoV-2 has integrated into the human viral landscape without broadly reshaping cross-reactive protection.
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