New mRNA vaccine strategy dramatically amplifies cancer-fighting T cells
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 Ensitrelvir cuts household COVID-19 risk when given after exposureEnsitrelvir cuts household COVID-19 risk when given after exposure
 
Ensitrelvir, an oral SARS-CoV-2 3C-like protease inhibitor, reduced symptomatic RT-PCR-confirmed COVID-19 among household contacts when given within 72 hours after symptom onset in the infected index patient. In the phase 3 SCORPIO-PEP trial, COVID-19 occurred in 2.9% of ensitrelvir recipients versus 9.0% of placebo recipients, with similar overall adverse-event rates.
 
 
 New mRNA vaccine strategy dramatically amplifies cancer-fighting T cellsNew mRNA vaccine strategy dramatically amplifies cancer-fighting T cells
 
Engineers from the University of Houston, MIT and Harvard have developed a new mRNA-based strategy that dramatically amplifies the T-cell response to vaccines - an advance that could lead to far more powerful cancer vaccines and stronger protection against infectious diseases.
 
   How an AI system learned to write expert-level scientific codeHow an AI system learned to write expert-level scientific code
 
ERA is an AI system that uses large language models and tree search to automatically write, test, and refine scientific software for measurable research tasks. Across bioinformatics, COVID-19 forecasting, time-series analysis, geospatial modeling, neuroscience, and numerical computation, ERA produced expert-level solutions that often surpassed established human-developed methods.
 
   Wastewater tracking catches hospital fungus before patients show symptomsWastewater tracking catches hospital fungus before patients show symptoms
 
A new UNLV-led wastewater surveillance study brings scientists one step closer in the global race to detect and deter skyrocketing cases of a potentially deadly drug-resistant fungus that puts hospital patients at risk of serious blood, heart, or brain infections.
 
   Mental disorders surpass other conditions as leading global cause of disabilityMental disorders surpass other conditions as leading global cause of disability
 
Nearly 1.2 billion people worldwide are living with a mental disorder, nearly double the number recorded in 1990.
 
 Brain scans find no evidence of widespread inflammation in long COVID
 
A new brain imaging study has found no evidence of widespread brain inflammation in patients suffering from prolonged symptoms after COVID-19 infection. Instead, the most severe long COVID symptoms were associated with increased brain activity in regions involved in mood and emotion.
 
 
 New computational pipeline improves effectiveness of pan-Ebola neutralizing antibodies
 
A team led by Professor Wei Yang at the National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, has developed a computational-experimental pipeline that synergistically optimizes antibody framework regions (FR) and complementarity-determining regions (CDR).
 
 
 Loneliness increased significantly over the past four decades in Japan
 
Despite widespread claims that social changes have intensified loneliness, no study has yet examined how loneliness has changed over time in Japan.
 
 
 Researchers track genetic changes in Brazil's rare Sabiá virus
 
Researchers track genetic changes in Brazil's rare Sabiá virusThe Sabiá virus causes an acute hemorrhagic and neurological syndrome. Four fatal cases have been recorded in the state of São Paulo since 1990.
 
 
 Common vegetable oil compound shows power to fight dangerous viruses
 
A common vegetable oil may hold the key to fighting some of the world's most dangerous viruses.
 
 
 Study defines realistic performance goals for pediatric emergency departments
 
Study defines realistic performance goals for pediatric emergency departmentsA large, multi-center study led by Ann & Robert H. Lurie Children's Hospital of Chicago derived "achievable benchmarks of care" (ABCs) using electronic health record data, which allows pediatric emergency departments across the country to set high yet realistic performance goals.
 
 
 Universal free school meals linked to fewer student suspensions
 
Universal free school meals linked to fewer student suspensionsA study published in Economic Inquiry provides new evidence that universal free school meals can meaningfully reduce out‐of‐school suspensions in both elementary and secondary schools.
 
 
 Boston Children's scientists create new booster-free mRNA vaccine strategy
 
In a new study published in Nature Immunology, researchers at Boston Children's Hospital demonstrated that pairing the original COVID-19 mRNA vaccine with an immune system enhancer, known as an adjuvant, extended the duration of the vaccine's protection in mice from a few months up to two years.
 
 
 Mid-career surgeons show highest likelihood of leaving clinical practice
 
Mid-career surgeons show highest likelihood of leaving clinical practiceSurgeons are an integral part of the health care system, supplying critical and urgent care in nearly every field of medicine.
 
 
 Emergency mental health admission costs for youth nearly quadruple over a decade
 
Emergency mental health admission costs for youth nearly quadruple over a decadeThe total cost of emergency admissions for mental health among children and young people in England rose from £22.5 million in 2012/13 to £87.3 million in 2021/22, finds research published online in the journal BMJ Open.
 
 
 Scientists urge advocacy to protect vital global vaccine research
 
Scientists and physicians should advocate to protect the vaccine research infrastructure that has saved an estimated 154 million lives over the past 50 years, according to a new commentary by researchers at Weill Cornell Medicine and the University of Washington.
 
 
 Engineers Develop New mRNA Adjuvant That Dramatically Amplifies Cancer-Fighting T Cells
 
Engineers Develop New mRNA Adjuvant That Dramatically Amplifies Cancer-Fighting T CellsEngineers from the University of Houston, MIT and Harvard have developed a new mRNA-based strategy that dramatically amplifies the T-cell response to vaccines - an advance that could lead to far more powerful cancer vaccines and stronger protection against infectious diseases.
 
 
 Researchers Use Yeast Sugar Molecules to Extend COVID Vaccine Immunity in Mice
 
Researchers Use Yeast Sugar Molecules to Extend COVID Vaccine Immunity in MiceIn a new study published in Nature Immunology, researchers at Boston Children's Hospital demonstrated that pairing the original COVID-19 mRNA vaccine with an immune system enhancer, known as an adjuvant, extended the duration of the vaccine's protection in mice from a few months up to two years. The combo also showed a more pronounced response against omicron viral components than the vaccine alone.
 
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