Large global study links higher alcohol intake to increased pancreatic cancer risk
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 New cancer vaccine shows promise against deadly pancreatic tumorsNew cancer vaccine shows promise against deadly pancreatic tumors
 
Pancreatic cancer has a five-year survival rate of just 13%, making it the deadliest cancer, according to the American Cancer Society.
 
 
 Large global study links higher alcohol intake to increased pancreatic cancer riskLarge global study links higher alcohol intake to increased pancreatic cancer risk
 
A pooled analysis of over 2.4 million adults across four continents shows a modest but significant increase in pancreatic cancer risk with higher alcohol consumption. The risk is especially pronounced for beer and liquor, and at higher intake levels in men and women.
 
   Rare pancreatic cancer patients show remarkable outcomes with immunotherapyRare pancreatic cancer patients show remarkable outcomes with immunotherapy
 
A new research paper was published in Volume 16 of Oncotarget on June 10, 2025, titled "Exceptional responders to immunotherapy in pancreatic cancer: A multi-institutional case series of a rare occurrence."
 
   Type 2 diabetes drug shows improvements for patients with progressive liver diseaseType 2 diabetes drug shows improvements for patients with progressive liver disease
 
The sodium glucose cotransporter 2 (SGLT-2) inhibitor drug dapagliflozin, widely used to treat type 2 diabetes, also shows improvements for patients with progressive liver disease, finds a clinical trial from China published by The BMJ today.
 
   Rising liver disease cases demand immediate attentionRising liver disease cases demand immediate attention
 
During the first meeting of the Global Think-tank on Steatotic Liver Disease, supported by the Barcelona Institute for Global Health (ISGlobal) and held in the Palau Macaya of Barcelona on 5–6 June, more than 100 international experts issued a stark warning: millions of people will continue to go unseen by healthcare systems unless early detection and person-centred care for liver disease are prioritized without delay.
 
 Fatty liver found in majority of type 2 diabetes patients
 
Fatty liver found in majority of type 2 diabetes patientsSix out of ten people with type 2 diabetes had fatty liver in a new study from Linköping University. Of these, only a small percentage had developed more severe liver disease.
 
 
 Eliminating stellate cells reduces liver metastasis in mouse models
 
Eliminating stellate cells reduces liver metastasis in mouse modelsThe prestigious journal Hepatology Communications reports on the discovery by the Cancer and Translational Medicine research group of the University of the Basque Country (EHU).
 
 
 Circular RNAs emerge as key players in hepatitis B-related liver cancer
 
Circular RNAs emerge as key players in hepatitis B-related liver cancerHepatitis B virus-induced hepatocellular carcinoma (HCC) remains a major global health burden, and new therapeutic and diagnostic approaches are urgently needed.
 
 
 Understanding MODY 5: A rare genetic form of diabetes
 
Understanding MODY 5: A rare genetic form of diabetesMODY 5 is a rare genetic diabetes subtype caused by HNF1B mutations or deletions, often presenting with early-onset diabetes and kidney, liver, or pancreatic abnormalities. Accurate genetic diagnosis is crucial, as MODY 5 frequently lacks family history and requires tailored, multidisciplinary care to prevent mismanagement and missed complications.
 
 
 Gut microbes offer clues for early detection of pancreatic cancer
 
Gut microbes offer clues for early detection of pancreatic cancerPancreatic cancer is a severe illness and major challenge in cancer medicine since it is difficult to diagnose, while potential therapies are scarce.
 
 
 PCSK9 protein controls how pancreatic cancer cells spread to the lung or liver
 
A protein called PCSK9 determines how pancreatic cancer cells metastasize to different parts of the body.
 
 
 Advanced organoid model recreates complex liver architecture
 
Advanced organoid model recreates complex liver architectureThe liver has a unique structure, especially at the level of individual cells. Hepatocytes, the main liver cells, release bile into tiny channels called bile canaliculi, which drain into the bile duct in the liver periportal region.
 
 
 Study sheds light on the link between gut microbiota, isoflavones, and geniposide hepatotoxicity
 
Study sheds light on the link between gut microbiota, isoflavones, and geniposide hepatotoxicityA recent study published in Engineering has shed light on the relationship between gut microbiota, isoflavones, and geniposide hepatotoxicity.
 
 
 Blood test detects early signs of liver transplant rejection
 
Blood test detects early signs of liver transplant rejectionLiver transplant is a lifesaving surgery, but a significant number of patients experience organ rejection or other complications.
 
 
 Oxytocin stimulates pancreatic hormones to improve insulin secretion
 
Oxytocin stimulates pancreatic hormones to improve insulin secretionA new research paper was published in Aging (Aging-US) Volume 17, Issue 5, on May 1, 2025, titled "Oxytocin modulates insulin and GLP-1 secretion in pancreatic islets."
 
 
 Switching to a low fat diet slows pancreatic precancer development in mice
 
Switching to a low fat diet slows pancreatic precancer development in micePancreatic cancer is one of the deadliest forms of cancer, killing 87% of patients within five years. Previous studies have shown that obesity can increase pancreatic cancer risk by around 50%.
 
 
 New intercellular network found to drive liver fibrosis progression
 
New intercellular network found to drive liver fibrosis progressionLiver fibrosis, a pathological condition in which the liver becomes stiff and scarred, commonly develops in the progression of chronic liver diseases such as chronic hepatitis and metabolic dysfunction-associated steatohepatitis (MASH).
 
 
 Exploring the intricate epigenetic regulatory network of lncRNAs in hepatocellular carcinoma
 
Exploring the intricate epigenetic regulatory network of lncRNAs in hepatocellular carcinomaA new review published in Genes & Diseases explores the intricate epigenetic regulatory network of long noncoding RNAs (lncRNAs) in hepatocellular carcinoma (HCC), shedding light on the profound impact of DNA methylation, histone modifications, RNA methylation, and microRNAs on lncRNA transcription.
 
 
 Exploring the dual role of microRNA-223 in hepatic fibrosis
 
Exploring the dual role of microRNA-223 in hepatic fibrosisAnnouncing a new article publication for BIO Integration journal. Liver fibrosis is caused by excessive extracellular matrix accumulation, which in turn is driven by activation of hepatic stellate cells.
 
 
 New molecular imaging agent shows high accuracy in detecting liver cancer
 
New molecular imaging agent shows high accuracy in detecting liver cancerA novel molecular imaging agent targeting glypican-3 (GPC3) has demonstrated high sensitivity and specificity in detecting hepatocellular carcinoma (HCC), including tumors smaller than one centimeter, according to results from a pilot clinical study.
 
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