Study reveals how bacterial collagenase efficiently breaks down collagen
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 Microplastics found in human bile may be associated with gallstonesMicroplastics found in human bile may be associated with gallstones
 
Findings show microplastics in bile may trigger cellular senescence, suggesting a link to gallstone disease and highlighting the need for further research.
 
 
 Study reveals how bacterial collagenase efficiently breaks down collagenStudy reveals how bacterial collagenase efficiently breaks down collagen
 
Collagen is an important protein that helps build the tissues of humans and animals. It is very strong because it is made of three protein strands twisted tightly together like a rope. Because of this sturdy structure, ordinary protein-cutting enzymes usually cannot break it down.
 
   Genetic variants may reduce effectiveness of popular diabetes drugsGenetic variants may reduce effectiveness of popular diabetes drugs
 
More than a quarter of people with Type 2 diabetes take GLP-1 receptor agonists, but the popular diabetes drugs might not work as well for people who have certain genetic variants, according to a new study by Stanford Medicine scientists and their collaborators.
 
   Rat hepatitis E virus may be a hidden cause of hepatitis in humansRat hepatitis E virus may be a hidden cause of hepatitis in humans
 
This Nature Communications review argues that rat hepatitis E virus is an emerging zoonotic cause of hepatitis that is likely underdiagnosed because current tests are limited and awareness remains low. It shows that ratHEV is widespread in urban rodent populations, can infect humans and some other animals, and may spread mainly through indirect environmental exposure rather than direct rodent contact.
 
   New blood test spots four cancers and other diseases by stripping away healthy DNA noiseNew blood test spots four cancers and other diseases by stripping away healthy DNA noise
 
MethylScan is a new low-cost cell-free DNA methylome test that removes much of the healthy blood DNA background, helping rare disease signals stand out more clearly. In more than 1,000 people, it showed strong performance for detecting four cancers, classifying liver diseases, and identifying organ-specific damage.
 
 New directions in cell therapy: iPSC platforms and in vivo reprogramming
 
New directions in cell therapy: iPSC platforms and in vivo reprogrammingAdvances in iPSC technology and in vivo reprogramming are expanding the possibilities for cell therapy. Explore the science behind these emerging strategies.
 
 
 The tumor microenvironment and cancer therapy
 
The tumor microenvironment and cancer therapyUnderstanding the cancer ecosystem reveals tumor microenvironment interactions, offering new insights for precision oncology and immunotherapy advancements.
 
 
 EV-RNAs show promise for IBD diagnosis and treatment
 
EV-RNAs show promise for IBD diagnosis and treatmentA research team led by Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, has published a comprehensive review in ExRNA that sorts out the diverse roles of extracellular vesicle-associated RNAs (EV-RNAs) in the development and progression of inflammatory bowel disease (IBD).
 
 
 Metabolic pathways drive progression from pancreatic lesions to cancer
 
Metabolic pathways drive progression from pancreatic lesions to cancerPancreatic ductal adenocarcinoma is the most common type of pancreatic cancer and has a low five-year survival rate.
 
 
 IBS diagnosis gaps persist across racial and gender groups in the U.S.
 
IBS diagnosis gaps persist across racial and gender groups in the U.S.A national survey study led by UCLA Health and Cedars-Sinai Medical Center found significant disparities in how irritable bowel syndrome, or IBS, is diagnosed across sex and racial groups in the U.S., with men and Black patients considerably less likely than women and white patients to receive a formal diagnosis.
 
 
 New target identified to overcome resistance in neuroendocrine tumors
 
New target identified to overcome resistance in neuroendocrine tumorsNeuroendocrine cells are unique in their ability to act both as nerve cells and hormone-making cells.
 
 
 Overnight machine perfusion enables safe daytime liver transplants
 
It is safe for patients to receive a donor liver that has been intentionally preserved overnight using machine perfusion to enable a daytime transplant.
 
 
 Hepatologists effectively deliver palliative care to patients with liver disease
 
Advanced liver disease (ALD) occurs when significant scarring causes the liver to lose function. Patients with ALD often have serious health challenges but have limited access to palliative care that could improve their quality of life.
 
 
 Fecal microbiota transplant can improve survival in severe C. difficile infection
 
A new study from the University of Minnesota Medical School demonstrated that fecal microbiota transplantation (FMT) can rapidly reverse systemic inflammation and improve survival in patients with fulminant Clostridioides difficile (C. difficile) infection - a life-threatening condition characterized by a sepsis-like state.
 
 
 AI tool predicts Barrett’s esophagus recurrence with high accuracy
 
A new artificial intelligence (AI)–based tool shows promise for improving surveillance in patients treated with endoscopic eradication therapies for Barrett's esophagus (BE) related dysplasia and early esophageal adenocarcinoma.
 
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