| |  Microplastics have become nearly impossible to avoid. They have been detected in oceans, drinking water and even the human body, but scientists are still uncovering how they affect human health. | |
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| |  Xenophagocytosis is a natural immune process that limits interspecies organ generation by eliminating living donor cells, report researchers at Institute of Science Tokyo, Japan. | |
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| |  Mega-scale exome sequencing of 1,032,116 people identified 59 independent genes linked to the TG:HDL ratio, including 44 rare-coding associations not detected in the previous largest analysis. Ultra-rare FNIP1 loss-of-function variants were associated with favorable fat distribution, lower liver fat and glycemia, and around 60% lower odds of a composite cardiometabolic disease outcome. | |
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| |  Hepatic encephalopathy (HE) is a neurologic complication of advanced liver disease, causing impaired functioning, reduced quality of life (QOL), and increased hospitalisation and mortality. | |
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| |  A newly published review highlights the pivotal role of FOXA2, a key transcription factor, in coordinating pancreatic development, maintaining islet cell identity, and regulating glucose homeostasis. | |
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| |  Patients with inflammatory bowel disease (IBD) face a significantly higher risk of psychiatric disorders starting two to three years before diagnosis and lasting up to a decade after, according to a nationwide study to be published in Clinical Gastroenterology and Hepatology. | |
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| |  Cancer cells have a voracious appetite for sugar-using it to fuel their rapid growth. This is why many scientists have tried to develop drugs that block cancer cells' metabolism by cutting off their sugar supply. | |
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| |  Lung infections are a constant risk for people living with cystic fibrosis (CF), a life-threatening genetic disorder which impairs lung function, predisposes people to persistent airway infections and exposes them to acquiring multidrug resistant infections. | |
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| |  Researchers developed a two-stage machine learning framework that detected diabetes and classified records as prediabetes, type 1, type 2, or type 3c diabetes using two public datasets. XGBoost showed strong internal performance, but inconsistent model rankings, non-standard variables, and the absence of external clinical validation limit immediate use. | |
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| |  Antisense oligonucleotides (ASOs) have been proposed as a therapeutic approach to shut down the production of faulty proteins in a wide variety of diseases, including cancer. | |
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| |  A new study led by researchers at The University of Texas MD Anderson Cancer Center has identified a way to reshape the gut microbiome that can enhance the delivery of certain chemotherapies to tumors, offering a potential strategy to make nanoparticle-based cancer drugs more effective. | |
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| |  Mechanosensitive Piezo ion channels, particularly Piezo1 and Piezo2, are gaining recognition as central regulators of digestive system physiology and disease. | |
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| |  A growing body of evidence suggests that a rare epithelial cell type known as the tuft cell may play a far more significant role in cancer than previously recognized. | |
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| |  The aberrant activation of the mTOR pathway and its crosstalk with other signaling cascades represent key drivers of hepatocellular carcinoma (HCC) progression. mTOR-mediated ferroptosis suppression has been implicated in HCC resistance to chemotherapy. | |
