Self-assembling antibody drugs successfully target multiple cancer receptors
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 Experts urge Mexico to integrate liver disease into chronic careExperts urge Mexico to integrate liver disease into chronic care
 
Liver disease may affect close to half of adults in Mexico, yet the country tracks it far less closely than the diabetes and obesity to which it is linked, according to a new paper by Jeffrey Lazarus, professor at the CUNY Graduate School of Public Health and Health Policy Professor (CUNY SPH), and colleagues, and released to coincide with the International Congress on Obesity taking place in Mexico City this week.
 
 
 Self-assembling antibody drugs successfully target multiple cancer receptorsSelf-assembling antibody drugs successfully target multiple cancer receptors
 
Modern anticancer medications that combine tumor-fighting drugs with proteins that specifically target cancer cells are a relatively new class of drug, often given to patients for whom standard chemotherapy has not worked.
 
   AI model predicts effective immunotherapy combinations for liver cancerAI model predicts effective immunotherapy combinations for liver cancer
 
Using computational tools, researchers from the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine have developed a method to predict which patients with a primary liver cancer called hepatocellular carcinoma (HCC) would most benefit from combination treatment using immunotherapy and a targeted therapy that blocks the growth signals that the tumor depends on.
 
   Study tests chronotype’s liver link and finds no significant associationStudy tests chronotype’s liver link and finds no significant association
 
Researchers found no significant association between chronotype and FibroScan-derived liver fat or stiffness in 119 medication-naïve adults with overweight or obesity. The exploratory findings cannot exclude smaller effects, particularly for fibrosis, and require confirmation in larger longitudinal studies.
 
   Study: Bariatric surgery is safe, effective for obese adolescents and young adultsStudy: Bariatric surgery is safe, effective for obese adolescents and young adults
 
A new study from researchers at LSU's Pennington Biomedical Research Center, FMOL Health | Our Lady of the Lake Regional Medical Center and Metamor Institute demonstrates that metabolic and bariatric surgery can be delivered safely and effectively for adolescents and young adults living with severe obesity, offering promising improvements in weight loss and obesity-related health conditions.
 
 Experimental drug shows promise against NRAS-driven melanoma
 
Experimental drug shows promise against NRAS-driven melanomaA research team from Huntsman Cancer Institute at the University of Utah (the U) reports that a groundbreaking pathway-targeted therapy could be an effective treatment for certain melanoma patients and fill an unmet clinical need for patients with advanced disease.
 
 
 Cold-exposed mothers pass metabolic protection to male rat offspring through milk
 
Cold-exposed mothers pass metabolic protection to male rat offspring through milkMaternal cold exposure during early pregnancy improved glucose control and reduced liver fat in male rat offspring, with benefits persisting into late adulthood. The findings implicate a breast milk LCA, gut microbiota, and Th17 immune pathway, while human cohort data showed an observational link between winter conception and lower MASLD risk.
 
 
 AGA launches AI-powered virtual assistant for gastroenterology and hepatology care
 
AGA launches AI-powered virtual assistant for gastroenterology and hepatology careThe American Gastroenterological Association (AGA) today announced the launch of Nigel, an artificial intelligence (AI)-powered virtual assistant developed exclusively for gastroenterology and hepatology.
 
 
 Study links PTSD to accelerated biological aging and chronic disease
 
Study links PTSD to accelerated biological aging and chronic diseasePost-Traumatic Stress Disorder (PTSD) remains a common condition affecting World Trade Center (WTC) responders 25 years after the attack on the Twin Towers.
 
 
 New form of hereditary prostate cancer can cause aggressive disease at a young age
 
New form of hereditary prostate cancer can cause aggressive disease at a young ageResearchers at the University of British Columbia have identified a new form of hereditary prostate cancer that, while rare, can cause aggressive disease at a young age.
 
 
 Blood-based gene tests show promise for pancreatic cancer screening
 
Blood-based gene tests show promise for pancreatic cancer screeningResearchers at Kanazawa University report the blood-based gene expression tests may enable early pancreatic cancer screening and improve long-term survival.
 
 
 Integrating gene signatures and multi omics improves liver cancer treatment
 
Integrating gene signatures and multi omics improves liver cancer treatmentHepatocellular carcinoma (HCC) remains highly fatal due to late diagnosis and scarce early biomarkers.
 
 
 Unlocking the potential of organoids in modern drug discovery
 
Unlocking the potential of organoids in modern drug discoveryExplore how organoids are unlocking new possibilities in modern drug discovery by improving disease modelling within DMTA-driven research workflows.
 
 
 KU Ansan Hospital introduces the "Da Vinci 5" robotic system to boost surgical precision
 
KU Ansan Hospital introduces the "Da Vinci 5" robotic system to boost surgical precisionThe Robotic Surgery Center at Korea University Ansan Hospital has further strengthened its precision surgical capabilities with the introduction of the latest robotic surgical system, the "Da Vinci 5," marking the first deployment among tertiary hospitals in Gyeonggi Province.
 
 
 Stealth nanoparticles improve pancreatic cancer treatment with fewer side effects
 
Stealth nanoparticles improve pancreatic cancer treatment with fewer side effectsPancreatic cancer is considered one of the most lethal cancer because it is often diagnosed late and is difficult to treat.
 
 
 Dual-compartment monitoring strategy improves evaluation of donor human livers
 
Dual-compartment monitoring strategy improves evaluation of donor human liversMore than 100,000 people in the United States are waiting for a lifesaving organ transplant. For patients in need of a liver transplant, determining whether a donor liver is healthy enough to transplant is a critical part of the process.
 
 
 Patient-derived organoids uncover new targets for chronic pancreatitis treatment
 
Patient-derived organoids uncover new targets for chronic pancreatitis treatmentAround three million people worldwide struggle with chronic pancreatitis, a condition wherein the pancreas becomes inflamed, scarred, and painful.
 
 
 New strategy boosts immune attack against pancreatic cancer
 
New strategy boosts immune attack against pancreatic cancerResearchers from the University of Minnesota Medical School have identified why pancreatic cancer is difficult for the immune system to recognize and attack, paving the way for a new approach to improve immunotherapy.
 
 
 Ultrasensitive biosensor detects early-stage liver fibrosis using small amount of blood
 
A research team led by Professor Jinsung Park of the Department of Biomechatronic Engineering at Sungkyunkwan University(SKKU), working jointly with Professor Pil-Soo Sung of the College of Medicine at the Catholic University of Korea and Professor Si-Hyun Bae, President of Eunpyeong St.
 
 
 Study reveals mechanism underlying HBV-induced liver inflammation
 
Chronic hepatitis B virus (HBV) infection remains a major cause of global liver morbidity, leading to progressive necroinflammation that often culminates in cirrhosis and hepatocellular carcinoma.
 
 
 Targeting CMPK2-intervened redox metabolism to mitigate hepatic ischemia-reperfusion injury
 
HIRI is a major clinical challenge that occurs when blood supply to the liver is temporarily interrupted and then restored, as commonly seen in liver resection and liver transplantation.
 
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