FDA approves daraxonrasib for metastatic pancreatic cancer following landmark clinical trial led by Dana-Farber
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 The scale told a similar story across three diets. The liver told a different oneThe scale told a similar story across three diets. The liver told a different one
 
In a randomized controlled trial of people with metabolically unhealthy obesity, approximately 10% weight loss improved insulin sensitivity and several cardiometabolic measures across ketogenic, Mediterranean, and very-low-fat plant-forward diets.
 
 
 FDA approves daraxonrasib for metastatic pancreatic cancer following landmark clinical trial led by Dana-FarberFDA approves daraxonrasib for metastatic pancreatic cancer following landmark clinical trial led by Dana-Farber
 
The U.S. Food and Drug Administration (FDA) has approved daraxonrasib, an oral multi-selective RAS(ON) inhibitor, for adults with metastatic pancreatic adenocarcinoma who have received at least one prior systemic therapy or are not candidates for multiagent systemic therapy.
 
   Alcohol-related liver cancer deaths were falling. Then the trend reversed during the COVID-19 pandemicAlcohol-related liver cancer deaths were falling. Then the trend reversed during the COVID-19 pandemic
 
A global analysis of GBD 2023 data found that alcohol-attributable liver cancer mortality increased modestly from 1990 to 2023, while mortality from alcohol-attributable cirrhosis, alcoholic cardiomyopathy, and alcohol use disorders declined.
 
   Could scorpion venom inspire new treatments for liver disease?Could scorpion venom inspire new treatments for liver disease?
 
Scorpion venom peptides show promising anti-inflammatory, antiviral, analgesic, and immunomodulatory effects, with experimental evidence suggesting that some candidates could target pathways involved in chronic liver disease and viral hepatitis. The review highlights Kv1.
 
   Semaglutide extended lifespan in older female mice, but that was not the only findingSemaglutide extended lifespan in older female mice, but that was not the only finding
 
Late-life semaglutide treatment slowed age-related physiological decline, attenuated multiple molecular hallmarks of aging, and extended median lifespan from 742 to 834 days in aged female mice. The drug reproduced many effects of calorie restriction while providing additional benefits in exploratory behavior, spatial memory, and glucose control, suggesting that some effects extend beyond reduced calorie intake alone.
 
 Early-onset bowel cancer shows distinct biological and clinical features
 
One of Australia's largest real world studies of younger adults with advanced bowel cancer has identified important differences between cancers diagnosed before and after the age of 50, which could help doctors tailor treatments for younger adults more effectively.
 
 
 Gut bacterial metabolite linked to inflammation in liver disease
 
Researchers have identified a link between specific activities in gut bacteria and the liver disease PSC.
 
 
 Ketogenic diet excels at reversing prediabetes and fatty liver
 
There is no shortage of popular diets to try, and they can generally produce weight loss if followed to the letter. But are all diet plans created equal in terms of reducing the cardiometabolic risks that come with obesity, such as Type 2 diabetes and liver disease?
 
 
 Laser therapy offers new hope for inoperable pancreatic tumors
 
UCI Health, the clinical enterprise of the University of California, Irvine, is conducting a first-in-human, phase 1 clinical trial using laser light to target localized but inoperable pancreatic tumors to help patients become cancer free.
 
 
 Symptomless liver condition linked to heart and kidney disease
 
A common liver condition thought to be harmless could be dramatically increasing the risk of heart disease, kidney failure and premature death, according to a new review led by University of Manchester and Northern Care Alliance NHS Foundation Trust researchers.
 
 
 Newly identified cells protect lung tumors from immune attacks
 
Researchers at Columbia University have discovered a new type of cell that protects lung cancers from attacks by the immune system.
 
 
 SHASTA trials show substantial triglyceride reductions with plozasiran
 
Plozasiran significantly reduced triglyceride levels in severe hypertriglyceridemia patients, showing promise in preventing acute pancreatitis after one year.
 
 
 Gut bacterial molecule discovered to drive serious bile duct disease
 
Researchers at the University of Oslo and Oslo University Hospital have, together with international collaborators, discovered that a small molecule made exclusively by gut bacteria can actively drive disease in the bile ducts and worsen primary sclerosing cholangitis (PSC), a serious liver and bile duct disease.
 
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