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The latest hepatology news from News Medical |
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 | | |  Is any level of alcohol safe? Major review reveals where drinking risks rise This Burden of Proof review found that alcohol consumption is associated with higher risks for several cancers, liver disease, pancreatitis, lower respiratory infections, tuberculosis, and atrial fibrillation. Although low-to-moderate drinking showed modest observational links with lower risks of type 2 diabetes, dementia, and some cardiovascular outcomes, the evidence was weaker and potentially biased. | | | | |  Retatrutide reshapes metabolism in obesity and type 2 diabetes, study finds Retatrutide altered circulating metabolites and lipids linked to fatty acid oxidation and insulin resistance in people with obesity, with or without type 2 diabetes. These biomarker changes suggest improved metabolic health, but the post-hoc analysis remains hypothesis-generating and does not prove direct clinical benefit. | |
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|  | | | | |  Chronic liver disease threatens millions across Europe, report finds Europe is facing a growing chronic liver disease threat, according to a new Series published today in The Lancet Regional Health – Europe, that engaged more than 75 co-authors from 30 countries and was led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by the "la Caixa" Foundation. | |  | | | | |  Tomato-soy juice curbs inflammation in obese adults Drinking tomato-soy juice loaded with compounds shown in animal studies to promote health lowered pro-inflammatory proteins in healthy adults with obesity after four weeks, a new study found. | | | | | | |  Daraxonrasib significantly extends survival in metastatic pancreatic cancer At the ASCO annual meeting, Dana-Farber's Brian Wolpin, MD, MPH, will present positive results from the RASolute 302 trial showing a substantial prolongation of survival for patients with previously treated metastatic pancreatic cancer, regardless of RAS mutation status, taking daraxonrasib, an investigational oral RAS(ON) multi-selective inhibitor, compared with chemotherapy. | |
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| | | |  A small clinical trial led by Dana-Farber Cancer Institute researchers put a Salk Institute idea to the test in patients: that activating the vitamin D receptor can help reshape the protective environment surrounding pancreatic tumors in ways that could make the notoriously difficult-to-treat cancer more vulnerable to therapeutic treatments. | | | | |  Researchers at Umeå University have conducted a unique three-dimensional mapping of an entire human pancreas. | | | | |  This Cystic Fibrosis Awareness Month, Children's Hospital Colorado (Children's Colorado) is highlighting a growing shift in care: starting cystic fibrosis treatment before birth to improve lifelong health outcomes and reduce hospital stays. | | | | |  NIR-II imaging has many advantages for preclinincal research as it supports deeper visualization with lower scattering and autofluorescence. | | | | | A group of researchers at the Medical University of South Carolina (MUSC) has recently developed a new stem cell therapy with a remarkable ability to reverse new-onset Type 1 diabetes (T1D) in a mouse model of the disease. | | | | |  A new type of peptide receptor radionuclide therapy (PRRT) appears to be safe in metastatic neuroendocrine tumor patients who have exhausted conventional treatment options. | | | | |  A triple-targeted preclinical therapy combining daraxonrasib, afatinib, and SD36 drove durable pancreatic cancer regression by blocking KRAS/RAS, EGFR/HER2, and STAT3 signaling. The approach prevented treatment resistance across mouse and human tumor-derived models, but remains preclinical and requires more clinically suitable drug combinations before human testing. | | | | |  Could the way doctors traditionally measure obesity allow a subset of people with obesity-related health risks slip through the cracks? | | | | |  Chronic pancreatitis is an inflammatory disease and is difficult to manage despite advancements in medical science. | | | | |  Snakes are threatened with extinction in many places around the globe. Disease, often caused by parasites or fungi, is thought to be one of the key factors alongside habitat destruction. | | | | |  Laparoscopic cholecystectomy is increasingly performed in children, yet bile duct injury remains a serious and potentially devastating complication. | | | | |  For decades, giant mitochondria-known as megamitochondria-have been recognized in liver biopsies from patients with alcohol-associated liver disease (ALD). | | | | |  The DNA changes responsible for a rare genetic condition causing babies to be born without a pancreas can now be identified in almost all affected children through genetic testing. | |
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