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The latest prostate cancer news from News Medical |
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 | | |  Breast and prostate cancer survival worsens with metabolic syndrome A SEER-Medicare analysis of more than 200,000 adults aged 66 and older found that metabolic syndrome was associated with about twice the adjusted hazard of death from any cause after breast or prostate cancer. The condition was also linked to higher cancer-specific, cardiovascular-specific, and liver-failure-specific mortality, although the observational design prevents causal conclusions. | | | | |  Allergies show a small but significant link to later cancer risk A systematic review and meta-analysis of 28 cohort-based studies found a weak but statistically significant association between allergic diseases and later cancer incidence. The signal was strongest in the Western Pacific region and among people with asthma, but high heterogeneity and limited subgroup evidence mean the findings require caution. | |
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| | | | |  BET proteins, especially BRD4, drive oncogenic transcription in solid tumours. First‑generation inhibitors (JQ1, molibresib, birabresib) showed preclinical promise but failed clinically due to modest efficacy, dose‑limiting thrombocytopenia, and resistance (isoform switching, compensatory PI3K/AKT/WNT signalling). | | | | |  In 2013, Angelina Jolie inspired a wave of testing for pathogenic variants of the gene BRCA1 by announcing that she carried a variant which left her at such high risk of breast cancer, she chose a preventive mastectomy. | | | | |  Patients whose physicians scored higher in the first year of the American Board of Internal Medicine's (ABIM) Internal Medicine Longitudinal Knowledge Assessment (LKA) were significantly less likely to receive low-value healthcare services, which cumulatively cost the U.S. healthcare system an estimated $100 billion each year. | |
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