Novel polygenic hazard score captures age variations of aggressive prostate cancer
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  January 18, 2018  
  Prostate Cancer  
  The latest prostate cancer news from News Medical  
 Novel polygenic hazard score captures age variations of aggressive prostate cancerNovel polygenic hazard score captures age variations of aggressive prostate cancer
 
An international team, led by researchers at the University of California San Diego School of Medicine, has developed and validated a genetic tool for predicting age of onset of aggressive prostate cancer, a disease that kills more than 26,000 American men annually.
 
 
 Research: Men who lack HSD17B4 gene may be more susceptible to treatment-resistant prostate cancerResearch: Men who lack HSD17B4 gene may be more susceptible to treatment-resistant prostate cancer
 
Cleveland Clinic researchers have confirmed for the first time a mechanistic link between the gene HSD17B4 and deadly, treatment-resistant prostate cancer.
 
   Research sheds new light on genetic, environmental factors that promote prostate cancer metastasisResearch sheds new light on genetic, environmental factors that promote prostate cancer metastasis
 
Prostate tumors tend to be what scientists call "indolent" - so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, the disease is invariably fatal.
 
   Men who follow Mediterranean diet have lower risk of aggressive prostate cancer, study findsMen who follow Mediterranean diet have lower risk of aggressive prostate cancer, study finds
 
In a new study published in The Journal of Urology, researchers determined that men who followed a Mediterranean diet, rich in fish, boiled potatoes, whole fruits, vegetables, legumes, and olive oil, and low consumption of juices had lower risk of aggressive prostate cancer than those who followed other dietary patterns like Prudent or Western diets.
 
   Prostate cancer’s gene-determined ‘immune landscape’ dictates tumor progressionProstate cancer’s gene-determined ‘immune landscape’ dictates tumor progression
 
The field of immunotherapy - the harnessing of patients' own immune systems to fend off cancer - is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy.
 
 Clinical study investigates lifestyle biomarkers in prostate cancer survivors
 
Clinical study investigates lifestyle biomarkers in prostate cancer survivorsAdvanced glycation end products, which have been linked to many chronic diseases, including diabetes, cardiovascular disease and cancer, build up in the body from birth due to normal metabolism but are often higher in those eating the high-fat, high-sugar, highly processed foods characteristic of the Western diet.
 
 
 Researchers find new way to halt growth of breast cancer cells
 
Researchers find new way to halt growth of breast cancer cellsAn international team of researchers led from Karolinska Institutet and Science for Life Laboratory in Sweden have found a new way of halting the growth of breast cancer cells.
 
 
 Novel gene expression analysis technique can accurately and quickly measure RNA
 
Novel gene expression analysis technique can accurately and quickly measure RNAA University of Illinois and Mayo collaboration has demonstrated a novel gene expression analysis technique that can accurately measure levels of RNA quickly and directly from a cancerous tissue sample while preserving the spatial information across the tissue --something that conventional methods cannot do.
 
 
 Stress accelerates development of pancreatic cancer, study shows
 
Stress accelerates development of pancreatic cancer, study showsA new study shows that stress accelerates the development of pancreatic cancer by triggering the release of "fight-or-flight" hormones. Beta-blockers--commonly used medications that inhibit these hormones--were found to increase survival in a mouse model of the disease.