How different types of bread impact cancer risk

Can't see this email? View it online

	Breast Cancer
	The latest breast cancer news from News Medical

	How different types of bread impact cancer risk Researchers find bread consumption is not linked to cancer risk, with whole-grain bread potentially reducing colorectal cancer and total cancer mortality.

	New vaccine shows potential in preventing recurrence of triple-negative breast cancer A small clinical trial shows promising results for patients with triple-negative breast cancer who received an investigational vaccine designed to prevent recurrence of tumors.

			CAR T cell therapy breakthroughs bring new hope for treating solid tumors Researchers advance CAR T cell therapy for solid tumors by innovating ways to overcome the unique barriers of solid tumor environments, with promising clinical results.

			Deep learning AI model outperforms humans in identifying pathologies A "deep learning" artificial intelligence model developed at Washington State University can identify pathology, or signs of disease, in images of animal and human tissue much faster, and often more accurately, than people.

	Neoantigen DNA vaccines improve survival and immunity in triple-negative breast cancer patients A new phase 1 trial demonstrates the safety and effectiveness of personalized neoantigen DNA vaccines, showing promising immune responses and improved recurrence-free survival in high-risk triple-negative breast cancer patients.

	New CAR T-cell therapy shows promise against aggressive HER2+ breast cancer One-third of HER2-positive (HER2+) tumors express the P95HER2 protein, which associates with an aggressive form of breast cancer with a poorer prognosis.

	AI-powered tool predicts gene activity in cancer cells from biopsy images To determine the type and severity of a cancer, pathologists typically analyze thin slices of a tumor biopsy under a microscope.

	Common heart failure drug reduces risk of chemotherapy-induced heart damage in cancer patients A commonly prescribed medication for heart failure was linked to a lower risk of heart damage, or cardiotoxicity, among high-risk cancer patients undergoing chemotherapy treatment using anthracyclines, according to preliminary late-breaking science presented today at the American Heart Association's Scientific Sessions 2024.

	New blood test detects early lung damage in cancer patients on targeted therapy New study introduces a simple blood test to detect early lung damage in cancer patients receiving novel therapy with antibody-drug conjugates (ADCs), which can sometimes cause serious, even fatal, lung disease (ILD).

	Researchers uncover key genes linked to DCIS progression A team of researchers mapping a molecular atlas for ductal carcinoma in situ (DCIS) has made a major advance toward distinguishing whether the early pre-cancers in the breast will develop into invasive cancers or remain stable.

	Study shows AI can predict prognosis in triple-negative breast cancer Researchers at Karolinska Institutet in Sweden have investigated how well different AI models can predict the prognosis of triple-negative breast cancer by analyzing certain immune cells inside the tumor.

	Engineered SNIPRs transform CAR T-cell precision for safer cancer therapy Researchers developed SNIPRs, innovative receptors that sense soluble ligands, enabling precise therapeutic control in CAR T-cells. This breakthrough enhances tumor targeting while reducing off-target effects, paving the way for advanced synthetic biology applications.

	Study shows how a single defective BRCA1 gene accelerates cancer development People inherit two copies of each gene -; one from each parent -; an evolutionary fail-safe to ensure survival even when one of them doesn't function.

	Female firefighters face elevated breast cancer risks due to toxic exposures It's well documented that firefighters have significantly higher rates of cancer than the general population, and these elevated rates have been associated with exposures to toxic chemicals on the job.

	Metabolic enzymes take on unexpected roles in cell division and DNA repair Researchers at the Centre for Genomic Regulation (CRG) reveal that metabolic enzymes known for their roles in energy production and nucleotide synthesis are taking on unexpected "second jobs" within the nucleus, orchestrating critical functions like cell division and DNA repair.

	AI models redefine TIL scoring in breast cancer but face challenges in real-world validation AI models analyzing tumor-infiltrating lymphocytes show promise in predicting outcomes for triple-negative breast cancer, but external validation reveals critical performance gaps.

	Rare genetic mutations in healthy women may be key to breast cancer origins Researchers at the University of British Columbia (UBC), BC Cancer, Harvard Medical School and Memorial Sloan Kettering Cancer Center (MSK) have pinpointed what could be the early genetic origins of breast cancer-;cancer-like mutations appearing in the cells of healthy women.

	Study identifies DNA collisions driving genetic changes in cancer Cancer researchers at the University of Chicago and the University of California, San Francisco (UCSF) have discovered that mutations in certain genes can lead to the accumulation of DNA errors, resulting in a specific type of genetic change known as large tandem duplications (TDs) that can arise from the collision of two critical cellular processes: transcription and DNA replication.