Epigenetic Silencing in Breast Cancer
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  November 12, 2018  
  Breast Cancer  
  The latest breast cancer news from News Medical  
 Beyond BRCA: Epigenetic Silencing in Breast CancerBeyond BRCA: Epigenetic Silencing in Breast Cancer
 
An interview with Professor William Newman, discussing his recent discovery in the field of breast cancer research, and the options that this will provide for women who have a family history of breast cancer but test negative for BRCA1/2 mutations.
 
   Polygenic screening could inform breast cancer risk in female survivors of pediatric cancerPolygenic screening could inform breast cancer risk in female survivors of pediatric cancer
 
A combined evaluation of common variants with small effects and rare predisposing mutations among young female childhood cancer survivors may further stratify this high-risk population for subsequent breast cancer risk.
 
   Study provides complete picture of genetic breast cancer susceptibility among pediatric cancer survivorsStudy provides complete picture of genetic breast cancer susceptibility among pediatric cancer survivors
 
St. Jude Children's Research Hospital researchers have evidence that common genetic variations can help to identify pediatric cancer survivors who are at increased risk for developing breast cancer while relatively young. The findings appear today in the journal Clinical Cancer Research.
 
 Breast Cancer as a Dynamic Disease
 
Breast Cancer as a Dynamic DiseaseAn interview with Dr. Andrew Ewald, discussing the influence of the myoepithelium on breast cancer growth and the importance of studying metastasis.
 
 
 Immunotherapy increases survival in some patients with metastatic triple negative breast cancer
 
Immunotherapy increases survival in some patients with metastatic triple negative breast cancerImmunotherapy improves survival in some patients with metastatic triple negative breast cancer, according to late-breaking results from the IMpassion130 trial reported at the ESMO 2018 Congress in Munich.
 
 
 Study: Mastectomy does not completely eliminate need for future breast imaging
 
Study: Mastectomy does not completely eliminate need for future breast imagingThe proportion of breast cancer patients who are eligible for breast conservation therapy, yet opt for mastectomy, is increasing, for reasons that include the desire to eliminate future screening and/or biopsy of the remaining breast tissue.
 
 
 Postmenopausal women who lost weight had lower risk of developing invasive breast cancer
 
Postmenopausal women who lost weight had lower risk of developing invasive breast cancerIn a study of postmenopausal women, participants who lost weight had a lower risk of developing invasive breast cancer than those who maintained or gained weight. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings suggest that weight loss may help lower postmenopausal women's breast cancer risk.
 
 
 Study of Nigerian breast cancer patients reveals prevalence of aggressive molecular features
 
Study of Nigerian breast cancer patients reveals prevalence of aggressive molecular featuresA study comparing DNA and RNA data from Nigerian breast cancer patients to patients in a United States database found that certain aggressive molecular features were far more prevalent in tumors from Nigerian women than in black or white American women.
 
 
 Advanced breast cancer patients can benefit from immunotherapy-chemotherapy combination
 
Advanced breast cancer patients can benefit from immunotherapy-chemotherapy combinationPatients with an aggressive form of advanced breast cancer can benefit from immunotherapy when used in combination with chemotherapy as first-line treatment, according to the results of a large international Phase III clinical trial published today in the New England Journal of Medicine and led by a researcher at the UPMC Hillman Cancer Center and the University of Pittsburgh School of Medicine.
 
 
 Immunotherapy trial offers new hope for people with aggressive breast cancer
 
Immunotherapy trial offers new hope for people with aggressive breast cancerThere is new hope for people with an aggressive type of breast cancer, as an immunotherapy trial shows for the first time that lives can be extended in people with triple-negative breast cancer.
 
 
 Study reveals new treatment option for women with advanced breast cancer resistant to hormone therapy
 
Study reveals new treatment option for women with advanced breast cancer resistant to hormone therapyTreatment with the cyclin dependent kinase 4/6 inhibitor palbociclib achieves a clinically meaningful improvement in overall survival in patients with hormone receptor positive human epidermal growth factor receptor-2 negative advanced breast cancer that has relapsed or progressed on hormonal therapy, according to the final analysis of overall survival results from the PALOMA-3 study reported at ESMO 2018.
 
 
 Targeting a protein could be key for suppressing breast cancer metastasis, study suggests
 
Targeting a protein could be key for suppressing breast cancer metastasis, study suggestsA new study by University of Kentucky Markey Cancer Center researchers suggests that targeting a protein known as collagen XIII could be key for suppressing breast cancer metastasis.
 
 
 New findings could benefit patients with triple-negative breast cancer
 
New findings could benefit patients with triple-negative breast cancerAbout 15 percent of breast cancers are classified as triple-negative, lacking receptors for estrogen, progesterone, and Her2.
 
 
 Shorter course of trastuzumab could be an option for women with HER2+ early breast cancer
 
Shorter course of trastuzumab could be an option for women with HER2+ early breast cancerWomen with HER2-positive early breast cancer with small tumours have similar disease-free survival and lower risk of cardiac toxicity with a nine-week course of adjuvant trastuzumab compared to those treated for one year, according to a subgroup analysis of the Short-HER trial reported at ESMO 2018 Congress in Munich.
 
 
 Fish oil based diets may suppress growth and spread of breast cancer cells
 
Fish oil based diets may suppress growth and spread of breast cancer cellsOmega-3 fatty acids, such as those typically contained in fish oil, may suppress the growth and spread of breast cancer cells in mice.
 
 
 High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients
 
High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patientsNearly one in six premenopausal women being treated for early stage breast cancer do not adhere adequately to tamoxifen therapy after one year of treatment, potentially putting themselves at increased risk of recurrence and reduced survival, a French prospective study reports at ESMO 2018.
 
 
 Wireless 'bio-patch' could aid recovery after breast reconstruction surgery
 
Wireless 'bio-patch' could aid recovery after breast reconstruction surgeryPatient studies of a new sensing device have proved it can provide early warning of the potential failure of breast reconstruction surgery, making it easier to take effective remedial action.
 
 
 New City of Hope CAR T cell trial focuses on HER2-positive breast cancer patients with brain metastases
 
New City of Hope CAR T cell trial focuses on HER2-positive breast cancer patients with brain metastasesWomen with HER2-positive breast cancer that has spread to the brain need more treatment options, and City of Hope and Mustang Bio Inc. are meeting that challenge.
 
 
 Survey: Only few women are informed by doctors that breastfeeding can lower cancer risk
 
Survey: Only few women are informed by doctors that breastfeeding can lower cancer riskA new survey shows that although nearly 60 percent of breastfeeding mothers knew about the link between breastfeeding and breast cancer risk reduction, just 16 percent say they learned this from a medical professional.
 
 
 Over 20% of women are paying out-of-pocket costs for their screening mammogram, shows study
 
Over 20% of women are paying out-of-pocket costs for their screening mammogram, shows studyMore than 20% of women aged 50-64 years and those aged 65-74 years with Medicare coverage reported paying out-of-pocket costs for their most recent screening mammogram, according to a study led by researchers from the Centers for Disease Control and Prevention.
 
 
 Radiation therapy can lower risk of breast cancer recurrence in patients with ‘good risk’ DCIS
 
Radiation therapy can lower risk of breast cancer recurrence in patients with ‘good risk’ DCISA subset of patients with low-risk breast cancer is highly unlikely to see cancer return following breast conservation surgery but can lower that risk even further with radiation therapy, finds a new long-term clinical trial report.
 
 
 Researchers develop diagnostic test to determine risk of developing malignant breast cancer
 
Researchers develop diagnostic test to determine risk of developing malignant breast cancerCurrently, with a pre-malignant breast cancer diagnosis from a biopsy, there are three options: observation, chemoprevention or surgery, all of which require a patient to make decisions while operating from a place of fear and unknown outcomes.
 
 
 Many breast cancer patients share and discuss their experiences on Twitter, study finds
 
Many breast cancer patients share and discuss their experiences on Twitter, study findsTwitter is a place where many cancer patients go to share and discuss their experiences of the disease. This is the main finding of a recent exploratory study (1), to be presented at the ESMO 2018 Congress in Munich, which analyzed the contents of over 6,000 tweets and retweets about breast cancer.
 
 
 Study: Women who participate in breast screening have greater benefit from treatments
 
Study: Women who participate in breast screening have greater benefit from treatmentsWomen who take part in breast screening have a significantly greater benefit from treatments than those who are not screened, according to a study of more than 50,000 women, led in the UK by Queen Mary University of London.
 
 
 New publication offers evidence-based content for global breast imaging medical community
 
New publication offers evidence-based content for global breast imaging medical communityJBI is a peer-reviewed publication that aims to provide high quality, evidence-based content for the global breast imaging medical community.
 
 
 Women not warned about cancer associated with breast implants
 
Women not warned about cancer associated with breast implantsBreast surgeons across the UK must ensure women are aware of BIA-ALCL, a non-Hodgkin’s lymphoma (a rare form of cancer) that is associated with implants; and more responsibility must be taken to diagnose and report cases, surgeons attending the 2018 London Breast Meeting have warned.