Novel gene network approach reveals new schizophrenia risk genes

	Schizophrenia
	The latest schizophrenia news from News Medical

	Novel gene network approach reveals new schizophrenia risk genes Scientists have long known that schizophrenia runs in families, but pinpointing exactly which genes contribute to risk has been like searching for needles in a haystack.

	Zebrafish study links altered neuronal genes to hyperarousal states The altered presence of tiny fragments of neuronal genes, called microexons, causes hyperarousal in zebrafish. This is the main conclusion of an international study led by the Pompeu Fabra University (UPF) and the Centre for Genomic Regulation (CRG).

			New brain probe simultaneously records and controls neuron activity A new breakthrough technology, co-developed by UCL scientists, that simultaneously records and manipulates neuron activity deep within the brain could transform our understanding of neural circuits and neurological conditions, such as Alzheimer's disease and schizophrenia.

			Scientists introduce a precise framework to study screen-saturated childhoods Children are growing up inside screens. A new peer-reviewed Thought Leaders Invited Review in Brain Health argues that neuroscience has been missing the word for what those screens are touching.

			Adverse life experiences alter brain structure linked to schizophrenia Carnegie Mellon University and University of California, San Francisco researchers found that childhood trauma, poverty, social isolation and other adverse life experiences are associated with brain changes linked to schizophrenia-spectrum disorders - findings that could help researchers identify people at risk earlier and develop interventions before severe symptoms emerge.

	Gut bacteria may help explain why fatigue appears before illness A small study of healthy Japanese adults found that fatigue was associated with distinct gut microbiome, microbial gene, and fecal metabolite patterns. The findings suggest fatigue may track with altered microbial energy metabolism and oxidative stress-related functional potential, but larger longitudinal studies are needed to test causality and clinical value.

	Cannabis and tobacco co-use lowers cognitive performance in at-risk youth New research shows that among people at clinical high risk for psychosis, cannabis and tobacco co-use was associated with lower cognitive performance compared to healthy controls.

	New study identifies brain circuits behind spontaneous and voluntary laughter Laughter is a universal social signal that connects us with others, but the brain regions underlying laughter are not well understood, in part because it's hard to elicit genuine laughter in the lab.

	New reference models track lifespan changes in brain wiring Researchers at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) at the Keck School of Medicine of USC have created one of the largest reference models ever developed for the human brain, using diffusion MRI scans from more than 54,000 people to chart how the brain's communication pathways develop, mature, and decline across the lifespan.

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