Achieving Dietary Supplements’ and Natural Health Products’ High Standards with NMR

Seminar Overview

The global nutraceutical market was estimated to be $140.1 billion USD in 2010. The dietary supplement (DS) natural health product (NHP) is part of this market; however, the New York Attorney General recently banned many DS and NHP products in NY State because the products are allegedly failed to meet their label claims for botanical content.

Consequently, consumers feel at risk and companies are losing money. Similar allegations have been made in Canada. Much of this problem lies in the premature use of unvalidated DNA barcoding technology for assessing identity and quality of the botanical supplements tested for compliance. DNA barcoding is an emerging technology and should not be used as the sole technology for the identification of pure unprocessed botanical ingredients.

DNA technology cannot identify or quantify a finished formulated botanical product(s)’ active ingredients. This is because most natural herbal products are composed of phytochemical extracts and excipients that are not suitable for DNA barcoding. An analysis method fit for the purpose of botanical extracts, which contains no plant DNA, is needed.

Bruker BioSpin is deeply committed to delivering the world's high standard method of quality and manufacturing control for DSs and NHPs with nuclear magnetic resonance (NMR) and metabolomics technology. This is a technology that along with conventional HPLC technologies is easily validated for identity and quality assurance of botanicals.

Nuclear magnetic resonance (NMR) has several advantages in that NMR measures the absolute concentration of ingredients in products by measuring real chemical phenomena. NMR is a robust technology that is reproducible across institutions. With automated batch to batch product analyses, companies and regulators can be assured that best practice methods and quality standards are achieved.

With NMR, patients and consumers can be certain their products contain the desired components in the expected quantity and conform to the product description.


Presenters achieving dietary

Kim Colson, Ph.D. (biography) - Business Development Manager - Bruker Biospin

Jonathan Ferrier, Ph.D. (biography) - Postdoctoral Fellow - University of Ottawa

Who should attend?

Managers, scientists and technicians who are responsible for the agriculture and quality control of dietary supplements and botanical material including: 

  • Dietary supplement producers
  • Dietary supplement suppliers
  • Regulatory agencies
  • Analytical service providers
  • Herbal product trade association representatives
  • Clinical trial leaders
  • Students considering careers in the dietary supplement trade
  • Botanists
  • Biologists
  • Agricultural Scientists

What you will discover?

In this webinar you will learn of the application of NMR to the quality control of a common natural health product utilized for the treatment of diabetes and in clinical testing for preeclampsia.

The modern day NMR spectrometer has evolved to enable the analysis of highly complex mixtures, including botanical material, and can provide information such as the botanical origin of the material, the identity and quantity of the components, and the material purity.  Through advances in automation, NMR is accessible to the non-traditional NMR user, including botanists, biologists, geneticists, and medical staff.

By taking advantage of the high compound specificity, high reproducibility, and absolute quantitative nature of NMR, herbal products and dietary supplements can be evaluated for identity, purity, strength and composition from a single experiment taking only 15 minutes or less.

Using a NMR spectrometer equipped with Assure-RMS software, dietary supplement producers and suppliers and agricultural scientists can customize the NMR spectrometer to perform fully automated analysis and reporting of their products to provide necessary testing results to ensure product consistency and quality within manufacturing specification and evaluation of agricultural practices.

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