Conformation-Dependent Amyloid Antibodies Webinar

Conformation-Dependent Amyloid Antibodies Webinar

What Do They See That We Don’t?

Listen in as Professor Charles Glabe, of the University of California, Irvine, reviews the structural variation of beta amyloid (Aβ) antibodies and discusses how Aβ can help further Alzheimer’s research.

Meet the Presenter

Dr. Charles Glabe received his Ph.D. from the University of California, Davis and Postdoctoral training at The Johns Hopkins University School of Medicine and UC San Francisco School of Medicine. His research program is focused on amyloid structural and conformational polymorphisms, and the role of different types of amyloid in disease pathogenesis.

Charles discovered that fibrils and prefibrillar oligomers represent alternative aggregation pathways for many different types of amyloids, and that they have distinct underlying structural motifs that are generic to the particular aggregation state. His current work is focused on characterizing the distribution of different populations of amyloid in human disease and transgenic mouse brain.

Webinar Topics

  • Conformational diversity of amyloids that accumulate in Alzheimer's disease
  • Why different types of amyloid accumulate at different times and places
  • Why single monoclonal antibodies do not recognize all conformations
  • Mechanism of antibody conformational specificity and immunoreactivity
  • Additional insight into antibody specificity

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