The third of a three-part webinar series on direct reprogramming presented by Dr Benedikt Berninger and Dr Alejandro Schinder
Review adult neurogenesis as a substrate for experience-dependent circuit remodeling and information flow in the hippocampus.
Interested in watching the first two webinars in this three-part series?
- Watch Part One: Direct Reprogramming of Somatic Cells into Induced Neurons
- Watch Part Two: Adult Neurogenesis and the Plasticity of Hippocampal Networks
About the Presenters
Dr Benedikt Berninger is currently a Professor of Physiological Chemistry at the University Medical Center of the University, Mainz. He received his doctoral degree in 1996 at the Ludwig Maximilians University in Munich for work on activity-dependent regulation of neurotrophin gene expression.
Benedikt then joined the lab of Professor Mu-ming Poo, as a postdoctoral fellow, at the University of California, San Diego, to study fast actions of neurotrophins in synapses and growth cones.
After a brief stay at the Karolinska Institute to acquaint himself with the rapid developments of the neural stem cell field, Benedikt returned to Munich and obtained a position as a lecturer and senior lecturer at the Ludwig Maximilians University, Munich.
In 2012 Benedikt received a call to the Johannes Gutenberg University of Mainz. His laboratory focuses on lineage progression of adult neural stem cells and on direct conversion of brain resident cells into induced neurons.
Dr Alejandro Schinder is a Principal Investigator at the Leloir Institute (CONICET) in Buenos Aires. He received his degree at the University of Buenos Aires in 1990, and in 1996 he received his PhD at the University of California San Diego, after working in the mechanisms of neuronal death.
Alejandro then then joined the lab of Professor Mu-ming Poo, as a postdoctoral fellow, at the University of California, San Diego, to study synaptogenesis and synaptic plasticity. He carried out a second postdoctoral training in Fred Gage’s lab at the Salk Institute to work in adult neurogenesis.
In 2002, Alejandro started his own group at the Leloir Institute in Buenos Aires, which focuses on adult neurogenesis, network plasticity and information processing in the hippocampus.
He is currently a Senior International Research Scholar of the Howard Hughes Medical Institute and a Fellow of the Humboldt Foundation.
- The influence of experience on the adult GC connectivity within a critical period in the development of new GCs
- Evidence for a developmental transition in the postsynaptic networks activated by adult-born GCs
- The role of changing GABAergic inhibition for the particular function of new GCs in information flow in the hippocampus
- Implication for these insights for installing neurogenesis outside the natural niches by transplantation or in vivo reprogramming