The Role of NNMT in Mitochondrial Bioenergetics in Parkinson's Disease Webinar
Recent studies have revealed that nicotinamide N-methyltransferase (NNMT) is able to regulate mitochondrial energy production, a key pathological feature of Parkinson’s disease
Join Dr Richard Parsons of Kings College London as he discusses this exciting discovery, including the effect of NNMT expression on Complex I activity and energy production, and the cytotrophic effects of NNMT expression on the neurone.
About the Presenter
Dr Richard Parsons gained his PhD in Biochemistry from The University of Birmingham, UK, studying the metabolism of cysteine in the body. He then undertook a post-doctoral position in the laboratory of David Ramsden, University of Birmingham, where he began his research into the expression of NNMT in PD patients. A subsequent move to the laboratory of Anthony Schapira, UCL, UK found him studying Complex I deficiency in PD.
Richard is currently Senior Lecturer in Biochemical Toxicology in the Institute of Pharmaceutical Science at King’s College London, UK where his research focusses upon the role of NNMT in neuronal biochemistry and bioenergetics. He has a number of international research collaborations investigating various aspects of NNMT biochemistry in cancer, and cytoskeletal dynamics in PD.
Richard is a member of the Editorial Advisory Board of the Biochemical Journal and a member of the Editorial Board of Frontiers in Chemistry (Medicinal and Pharmaceutical Chemistry).
- The mechanics of mitochondrial energy production
- The function and phenotypic expression of NNMT in the PD population
- The effect of NNMT expression upon Complex I activity and energy production
- The various cytotrophic effects of NNMT expression upon the neurone
- The molecular pathways underlying these