A Guide to Solvent Evaporation

Despite the availability of different solvents and sample formats, no particular technique provides a common solution. Evaporation is integral in many applications, however facilities continue to utilize slow and awkward systems. Genevac’s downloadable guide provides details of:

  • Basic solvent removal
  • Nitrogen blow-down evaporation
  • Vortex and rotary evaporation
  • Vacuum drying
  • Freeze drying
  • Centrifugal evaporation

Avoiding Common Evaporation Problems

In order to ensure efficiency during evaporation and concentration of samples, the following issues should be avoided:

  • Inefficient analyte recovery
  • Bumping
  • Product loss in container
  • Loss of product when transferring
  • Poor solvent recovery (Figure 1)

Condenser with removable jug, for safe handling of recovered solvents

Figure 1. Condenser with a removable jug, for safe handling of recovered solvents.

Safety can be ensured by protecting the products against excessive heat and eliminating cross-contamination.

Technologies for Specific Applications

Many technological innovations have been devised to accommodate the evaporation process in a variety of applications. These include:

  • Heat sensitive samples
  • Solvent mixtures
  • High boiling point solvents
  • Low auto-ignition solvents
  • Volatile compounds
  • Corrosive solvents (Figure 2)
  • Lyophilization
  • Crystallography

System designed to withstand solvents such as HCI and TFA.

Figure 2. System designed to withstand solvents such as HCI and TFA.

Genevac Products

Genevac offers the following products:

  • EZ-2 personal centrifugal evaporators
  • HT Series high throughput evaporators
  • Rocket synergy high-speed centrifugal evaporators
  • miVac sample concentrators
  • Sample holders


An exhaustive range of concentration and evaporation systems have been developed to accommodate a variety of samples and applications. Optimizing performance, a suitable cold trap and vacuum pump can serve as essential components. Advanced technology ensures sample integrity, giving much-needed confidence to operators.

About SP Scientific Products

SP Scientific is the synergistic collection of well-known, well-established, and highly regarded scientific equipment brands — VirTis, FTS Systems, Hotpack, Hull, Genevac, PennTech, and most recently i-Dositecno — joined to create one of the largest and most experienced companies in freeze-drying/lyophilization, production fill-finish lines, centrifugal evaporation and concentration, temperature control/thermal management, glassware washers and controlled environments.

More than a scientific equipment supplier, SP Scientific represents brands that distinguish themselves by thoroughly assist customers in matching equipment to particular application needs. Fortune 500, pharmaceutical, aerospace, automotive, medical device, diagnostic kit, and biotechnology companies — as well as government facilities, universities, and colleges, are among the organizations served on a daily basis.

SP Scientific is part of SP Industries, Inc., a leading designer, and manufacturer of state-of-the-art laboratory equipment, pharmaceutical manufacturing solutions, laboratory supplies and instruments, and specialty glassware. SP's products support research and production across divers end-user markets including pharmaceutical, scientific research, industrial, aeronautic, semiconductor, and healthcare.

SP's three flagship brands -- SP Scientific, SP Scienceware, and SP Ableware-- represent over 400 combined years of experience, quality, and innovation. Headquartered in Warminster, Pennsylvania, SP Industries has production facilities in the USA and Europe and offers a world-wide sales and service network with full product support including training and technical assistance.

Sponsored Content Policy: News-Medical.net publishes articles and related content that may be derived from sources where we have existing commercial relationships, provided such content adds value to the core editorial ethos of News-Medical.Net which is to educate and inform site visitors interested in medical research, science, medical devices and treatments.

Last updated: Sep 4, 2020 at 8:43 AM


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