A Guide to Solvent Evaporation


Despite the availability of different solvents and sample formats, no particular technique provides a common solution. Evaporation is integral in many applications, however facilities continue to utilize slow and awkward systems. Genevac’s downloadable guide provides details of:

  • Basic solvent removal
  • Nitrogen blow-down evaporation
  • Vortex and rotary evaporation
  • Vacuum drying
  • Freeze drying
  • Centrifugal evaporation

Avoiding Common Evaporation Problems

In order to ensure efficiency during evaporation and concentration of samples, the following issues should be avoided:

  • Inefficient analyte recovery
  • Bumping
  • Product loss in container
  • Loss of product when transferring
  • Poor solvent recovery (Figure 1)

Condenser with removable jug, for safe handling of recovered solvents

Figure 1. Condenser with removable jug, for safe handling of recovered solvents. Image credit: SP Scientific

Safety can be ensured by protecting the products against excessive heat and eliminating cross contamination.

Technologies for Specific Applications

Many technological innovations have been devised to accommodate the evaporation process in a variety of applications. These include:

  • Heat sensitive samples
  • Solvent mixtures
  • High boiling point solvents
  • Low auto-ignition solvents
  • Volatile compounds
  • Corrosive solvents (Figure 2)
  • Lyophilization
  • Crystallography

System designed to withstand solvents such as HCI and TFA.

Figure 2. System designed to withstand solvents such as HCI and TFA. Image credit: SP Scientific

Genevac Products

Genevac offers the following products:

  • EZ-2 personal centrifugal evaporators
  • HT Series high throughput evaporators
  • Rocket synergy high speed centrifugal evaporators
  • miVac sample concentrators
  • Sample holders


An exhaustive range of concentration and evaporation systems have been developed to accommodate a variety of samples and applications. Optimizing performance, a suitable cold trap and vacuum pump can serve as essential components. Advanced technology ensures sample integrity, giving much-needed confidence to operators.

About GenevacSP Scientific logo

Genevac's high performance centrifugal solvent evaporator systems are designed for use in chemistry, biology and analytical science applications and are in use in laboratories worldwide.

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Last updated: May 16, 2020 at 6:58 PM


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