Assessment of Evaporative Sample Preparation Methods in Hair Samples

Hair analysis is performed to determine drug usage, trends of usage, and evaluate persistent alcohol consumption, which can be a practical tool examining deaths caused by drugs or crimes facilitated by drugs.

Body hair follicles accumulate drug/drug metabolites, lodging into hair strands when they grow out. Residual analysis aids in assessing the amount of drug consumed over a period of time providing conclusive proof of isolated, regular, or acute drug use.

Equipment Validation

Whenever a new instrument is introduced into highly controlled environments, the equipment should be checked and calibrated thoroughly. Contamination produces artifacts within samples, which may invalidate analyses and result in erroneous results. Sample recovery and cross-contamination present the foremost issues, particularly for highly volatile analytes existing in trace quantities.

The Genevac® EZ-2 centrifugal vacuum evaporator accommodates large numbers of samples. ROAR Forensics assessed the Genevac EZ-2 system (Figure 1) as part of its evaluation process prior to introducing it into the lab using drugs of abuse (DoA) solution and hair alcohol marker (EtG) to assess the for cross-contamination. They also assessed the recovery of amphetamine that is known to be highly volatile.

Genevac EZ-2

Figure 1. Genevac EZ-2.

Conclusion

During the evaporation processes chosen for DoA or EtG, there was no trace of cross-contamination. The evaporation system could well be used to evaporate the SPE eluent comprising amphetamine, without any major loss. Likewise, the Genevac evaporation program applied for DoA also appears to facilitate excellent recovery of amphetamine.

Acknowledgments

Produced from materials authored by Dr. Eleanor I Miller and Dr. Simon P Elliott ROAR Forensics, Malvern, UK.

References and Further Reading

  1. Dri-Pure Sample Integrity Protection System. An Evaluation by GlaxoWellcome. Dr Martin Deal (1999), available via www.Genevac.com
  2. Society of Hair Testing. Recommendations for hair testing in forensic cases. Forensic.Sci.Int. 145:83-84 (2004).

About SP Scientific Products

SP Scientific is the synergistic collection of well-known, well-established, and highly regarded scientific equipment brands — VirTis, FTS Systems, Hotpack, Hull, Genevac, PennTech, and most recently i-Dositecno — joined to create one of the largest and most experienced companies in freeze-drying/lyophilization, production fill-finish lines, centrifugal evaporation and concentration, temperature control/thermal management, glassware washers and controlled environments.

More than a scientific equipment supplier, SP Scientific represents brands that distinguish themselves by thoroughly assist customers in matching equipment to particular application needs. Fortune 500, pharmaceutical, aerospace, automotive, medical device, diagnostic kit, and biotechnology companies — as well as government facilities, universities, and colleges, are among the organizations served on a daily basis.

SP Scientific is part of SP Industries, Inc., a leading designer, and manufacturer of state-of-the-art laboratory equipment, pharmaceutical manufacturing solutions, laboratory supplies and instruments, and specialty glassware. SP's products support research and production across divers end-user markets including pharmaceutical, scientific research, industrial, aeronautic, semiconductor, and healthcare.

SP's three flagship brands -- SP Scientific, SP Scienceware, and SP Ableware-- represent over 400 combined years of experience, quality, and innovation. Headquartered in Warminster, Pennsylvania, SP Industries has production facilities in the USA and Europe and offers a world-wide sales and service network with full product support including training and technical assistance.


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Last updated: Sep 4, 2020 at 8:43 AM

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