How to Test Moisture in Pharmaceuticals

Accurate Results for Granulations, Tablets and Lyophilized Samples

Precise control of moisture is crucial in pharmaceuticals to attain maximum tablet performance, API effectiveness and shelf life. For over 30 years Computrac has been pioneers in the field and are a name which can be trusted when it comes to moisture.

The Computrac range of moisture, solids and ash analyzers possess a huge scope of benefits; sturdiness to meet the requirements of the production floor, accuracy levels which are sufficient for the lab, and adaptability to permit the handling of almost any application.

Using a single sample, in as little as 30 minutes, the Computrac MAX 5000XL® can give results on both the USP methods 281 and 731. Furthermore, for work involving lyophilized or low-moisture samples, the Computrac Vapor Pro® XL can undertake a moisture-specific test right in the sample bottle with the lowest possible levels of handling.

There is a Computrac that can help you in making your moisture, solids and ash testing more accurate, faster, and more consistent regardless of your application requirements.

Proven, Adaptable and Sensitive

Some of the leading names in pharmaceutical manufacturing and research rely on Computrac. Their apparatus can identify moisture content as low as 10 parts per million (ppm). From a single sample, users can obtain results for USP 281 and USP 731 in less than 30 minutes.

IQ/OQ/PQ Support and On-Site Service Available

Users can simplify the IQ/OQ/PQ process by employing documents and support which are tailored to suit Computrac instruments. Computrac also supplies on-site training, calibration and repair services.

Recommended Instruments

Computrac® Max® 4000XL – Moisture & Solids Analyzer

Specifications

  • Has the capacity to store up to 250 program settings and 1,000 test results
  • Can process sample sizes ranging from 100 mg to 40 g
  • Operates at a temperature range of 25 °C – 275 °C
  • Boasts a moisture detection range of 0.005% – 100%
  • Web server and printer are available

Suited for:

  • USP 731
  • Gel Caps
  • Granulations
  • Tablets

Computrac® Vapor Pro® XL – Moisture Specific Analyzer

Specifications

  • Can process sample sizes ranging from 10 mg to 8 g
  • Web server and printer are available
  • Boasts a moisture detection range of 10 ppm – 100%
  • Operates at a temperature range of 25 °C – 300 °C
  • Has the capacity to store up to 250 program settings and 1,000 test results

Suited for:

  • Stoppers
  • Granulations
  • Lyophilized samples
  • Medicated Bandages
  • Low moisture samples
  • Coated beads

Computrac® Max® 5000XL – Moisture, Solids & Ash Analyzer

Specifications

  • Web server and printer are available
  • Boasts a moisture detection range of 0.1% – 99.9%
  • Operates at a temperature range of 25 °C – 600 °C
  • Can process sample sizes ranging from 100 mg to 100 g
  • Has the capacity to store up to 250 program settings and 1,000 test results

Suited for:

  • USP 731 & USP 281
  • Ash testing / Residue on Ignition
  • High Temperature Testing

About AMETEK Arizona Instrument

Initially known as the Quintel Corporation, Arizona Instrument LLC was founded in 1981 by a group of engineers breaking away from The Motorola Corporation who were dedicated to the idea of providing precision moisture analysis instruments that were accurate, reliable, and easy to use.

The first instrument released was the MA Moisture Analyzer, but the company quickly expanded its Computrac® moisture analysis line and became an accepted leader in moisture analysis, setting a standard that has been adopted by many Fortune 500 companies. Today the Computrac® line is comprised of three technologies: rapid loss-on-drying, high temperature loss-on-ignition, and moisture specific analysis using polymer capacitance sensor, GREEN alternative to Karl Fischer.

In 1986, Arizona Instrument acquired Jerome Instrument Corporation the manufacturers of the Jerome® toxic gas analyzers. At the time of purchase the corporation had an established reputation for accuracy and durability, which complemented and added depth to the Arizona Instrument’s offerings; and these traditions continue today. The Jerome® line is comprised of instruments used for detecting low-level mercury and hydrogen sulfide gases. Both portable detection and fixed position monitoring solutions are available, using gold film sensor and atomic fluorescence spectroscopy technologies as the method of detection.

Through the years Arizona Instrument has pursued and maintained a total quality management system, being certified initially as ISO 9001:1994 then ISO 9001:2000 and most recently ISO 9001:2008. Though the company is located in Chandler, Arizona, its distributors and service centers located around the world provide consistent, dependable service to its many customers worldwide.


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Last updated: Feb 11, 2019 at 5:13 AM

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