Assays for Research into Caspase Activity

Caspases are proteases, enzymes that assist in protein hydrolysis, which play a key role in apoptosis (cell death). Due to their role in a key cellular process caspase research is an area of intense activity.

Researching the activity of caspases usually involves running a caspase activity assay. In such an assay peptide substrates, or similar, are introduced to caspases in either live cells or cell extract. The rate at which the substrate is processed can be used to determine the level of caspase activity in a sample and, if specific substrates are used, information about the types of caspase present can be determined.

Activity Assays for Caspase in Live Cells

The following activity assays can be analyzed using either a plate reader, microscope or flow cytometer.

Assay Assays
Caspase 3 ab39401, ab39383
Caspase 1 ab39412
Caspase 2 ab39830, ab39794
Caspase 4 ab65659, ab65658
Caspase 5 ab65661, ab65660
Caspase 6 ab39709, ab39707
Caspase 7 ab157404
Caspase 8 ab39700, ab39534
Caspase 9 ab65608, ab65607
Caspase 10 ab65663, ab65662
Caspase 12 ab65664

Activity Assays for Caspase in Cell Extract

The following activity assays can be analyzed using either a plate reader with fluorimetric or colorimetric analysis.

Analyte Reagents and assay kits
Pan caspase ab112130, ab65611, ab65616
Caspase 3 ab65613
Caspase 2 ab65612
Caspase 8 ab65618, ab65614
Caspase 9 ab65615, ab65619
Caspase 12 ab65610

Abcam can also provide assays for research into caspase inhibition.

About Abcam

Abcam is a global life sciences company providing highly validated antibodies and other binders and assays to the research and clinical communities to help advance the understanding of biology and causes of disease.

Abcam’s mission is to serve life scientists to help them achieve their mission faster by listening to their needs, continuously innovating and improving and by giving them the tools, data and experience they want. Abcam’s ambition is to become the most influential life science company for researchers worldwide.

Sponsored Content Policy: publishes articles and related content that may be derived from sources where we have existing commercial relationships, provided such content adds value to the core editorial ethos of News-Medical.Net which is to educate and inform site visitors interested in medical research, science, medical devices and treatments.

Last updated: May 14, 2019 at 8:25 AM


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