Caspases are proteases, enzymes that assist in protein hydrolysis, which play a key role in apoptosis (cell death). Due to their role in a key cellular process caspase research is an area of intense activity.
Researching the activity of caspases usually involves running a caspase activity assay. In such an assay peptide substrates, or similar, are introduced to caspases in either live cells or cell extract. The rate at which the substrate is processed can be used to determine the level of caspase activity in a sample and, if specific substrates are used, information about the types of caspase present can be determined.
Activity Assays for Caspase in Live Cells
The following activity assays can be analyzed using either a plate reader, microscope or flow cytometer.
Activity Assays for Caspase in Cell Extract
The following activity assays can be analyzed using either a plate reader with fluorimetric or colorimetric analysis.
Abcam can also provide assays for research into caspase inhibition.
Abcam is a global life sciences company providing highly validated antibodies and other binders and assays to the research and clinical communities to help advance the understanding of biology and causes of disease.
Abcam’s mission is to serve life scientists to help them achieve their mission faster by listening to their needs, continuously innovating and improving and by giving them the tools, data and experience they want. Abcam’s ambition is to become the most influential life science company for researchers worldwide.
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