Adipokine Signaling

Among humans, white adipose tissue (WAT) can comprise up to 20% of male body mass and 25% of female body mass. Its cells, which contain a single large fat droplet, also include insulin receptors, growth hormones, norepinephrine and glucocorticoids.

Furthermore, adipose tissue is a key endocrine tissue that discharges various highly active molecules into circulation, including the adipocytokines (or adipokines) which comprise leptin, resistin, adiponectin and visfatin, among others. More classical cytokines are also secreted, possibly by inflammatory cells permeating fat, and comprise TNF-α, IL-1β, IL-6, IL-8, IL-10, TGF-β, nerve growth factor, etc., all of which are associated with the inflammatory response.

Obesity is attended by generalized inflammation and dysregulation of cytokine generation. The adipokine leptin, a protein product of the Ob gene, is an effective appetite suppressant and once at the forefront of type 2 diabetes and obesity treatment research.

Despite the fact that brain resistance to leptin suggests that this treatment might not be possible, there is still considerable interest in the abundance of protein hormones emitted by adipose tissue. This is compounded by research which has demonstrated that receptors for these adipokines are broadly expressed throughout the cardiovascular and immune system.

The impact of adipocytokines (including both adipokines and the classical cytokines) on vascular function, immune regulation and adipocyte metabolism renders them important factors in the pathogenesis of metabolic syndrome, a collection of clinical symptoms comprising obesity, insulin resistance, hypertension and dyslipidemia. BioVision proudly offers an array of reagents for research into adipokine signalling, as well as diabetes and obesity studies.

BioVision Incorporated

BioVision, Inc., is a privately held Life Science company headquartered in the beautiful San Francisco Bay Area.

BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, etc. BioVision's products are currently being sold in more than 60 countries worldwide.


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Last updated: Mar 19, 2020 at 1:32 PM

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