Anaplastic Lymphoma Kinase (ALK) Inhibitors

Small molecule inhibitors of EGFR (epidermal growth factor receptor) have been broadly utilized in lung cancer therapy. A minor subset (3–13 %) of non-small cell lung cancer (NSCLC) has been proven to cause rearrangements in the ALK (anaplastic lymphoma kinase) gene.

In the last decade, research has demonstrated that ALK inhibitors offer considerable advantages in the administration of ALK-positive NSCLC as in comparison to standard chemotherapy. The treatment of patients with advanced NSCLC possessing chromosomal rearrangements of ALK has been transformed by the evolution of Crizotinib, a small molecule inhibitor of the tyrosine kinases ALK, ROS1, and MET.

Nevertheless, the restricted progression-free survival (PFS), coupled with the rate of advancement in the CNS utilizing Crizotinib for the treatment of NSCLC, have prompted the development of second-generation ALK-inhibitors. These inhibitors, which include Ceritinib and Alectinib, can impede most of the clinically detected ALK mutations that cause resistance to Crizotinib.

A number of new Tyrosine Kinase Inhibitors (TKIs) are at different stages of clinical development for ALK-positive cancers. Many of these agents have activity both in the CNS and in cancers that have developed resistance to Crizotinib. BioVision proudly supplies a broad selection of ALK inhibitors for research.

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BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, etc. BioVision's products are currently being sold in more than 60 countries worldwide.

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Last updated: Mar 19, 2020 at 1:27 PM


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