Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase. At first, it was identified as the defective protein in human X-linked agammaglobulinemia (XLA) and is also called B-cell progenitor kinase (BPK) or agammaglobulinemia tyrosine kinase (ATK).
BTK’s Role in Humans
BTK, which is a member of the Tec family of protein tyrosine kinases, has a vital role to play in the development, differentiation, and signaling of B-lymphocytes. XLA in humans and X-linked immunodeficiency (Xid) in mice are caused by mutations in the Btk gene. When the Btk gene is activated, a cascade of signaling events is triggered, resulting in the generation of cytoskeletal rearrangements, calcium mobilization and fluxes, and transcriptional regulation involving nuclear factor of activated T cells (NFAT) and nuclear factor-kappaB (NF-kB).
Inhibition of BTK
BTK inhibition is of therapeutic importance while treating B cell chronic lymphocytic leukemia (B-CLL) and B cell-related hematological cancers (for example, non-Hodgkin lymphoma (NHL), as well as autoimmune diseases such as rheumatoid arthritis. BioVision is pleased to provide numerous small molecule BTK inhibitors for research.
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