Urea Cycle: Rediscovering a Classic

The result of a condensation reaction between bicarbonate and ammonia is urea. Every mammal, including humans, uses the urea cycle to expel excess nitrogen. Yet, this cycle is not always active.

Considerable changes can be seen in individuals under starving conditions and/or consuming high levels of proteins. One of the participants of the cycle, arginase, has received significant attention as a potential therapeutic target against leukemia, cardiovascular diseases, gliomas and sarcomas.

In the urea cycle, five enzymatic reactions take place: the first two reactions are mitochondrial and the last three reactions are cytosolic. BioVision provides one of the most comprehensive series of assays for measuring a range of cofactors, metabolites, and enzymes involved in this pathway.

Components of the Urea Cycle

BioVision is excited to provide the most complete series of products for the detection and measurement of key players of the urea cycle. Many of our kits in this area are first in the market and are used for the measurement and quantification of arginine, ornithine and numerous other related targets. BioVision’s products are specific, affordable, simple, high-throughput adaptable, validated (lysates, serum, urine,) and do not need specialized personnel or instrumentation.

Key Features

  • Sensitive: colorimetric/fluorometric format
  • Convenient: minimal sample preparation, fast protocols (less than 2 hours)
  • Adaptable: works with most of the commonly available instrumentations
  • High Throughput Screening (HTS) compatible
  • Non-radioactive, versatile assays (Microplate)
  • Specific, homogeneous assay
  • Cost effective: 100 assays

Figures: (A) Estimations of L-arginine in human serum and orange juice using K749-100. (B). Inhibition of ARG1 enzyme activity by Amino-2-Borono-6-Hexanoic Acid (ABH) using K567-100. IC50 of ABH was determined to be 1.39 ± 0.10 µM. Assays were performed following kit protocols.

About BioVision Incorporated

BioVision, Inc., is a privately held Life Science company headquartered in the beautiful San Francisco Bay Area.

BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, etc. BioVision's products are currently being sold in more than 60 countries worldwide.

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Last updated: Feb 21, 2020 at 9:30 AM


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