Discover how to fight physical and mental fatigue

Mental and physical fatigue is often referred to as asthenia (from the Greek, devoid of strength), presenting as energy loss, irritability, weakness and anxiousness caused by a range of factors, including:

  • Intense, sports-related activity
  • The aging process
  • Stressful life events
  • Changes in or irregular lifestyle
  • An unbalanced diet
  • Seasonal changes
  • Poor sleep hygiene

Discover how to fight physical and mental fatigue

Image Credit: PharmaNutra Spa

Persistent asthenia may require the integration of vitamins, minerals and nutrients to bolster the body and deliver the energy that is needed to deal with daily life.

Discover how to fight physical and mental fatigue

Image Credit: PharmaNutra Spa

Apportal® is a food supplement that contains nineteen essential nutrients which are key in combatting physical and mental fatigue. These ingredients have four main functions: immune, muscular, antioxidant and energizing.

Immune function

Immune function is aided by the synergistic action of iodine, vitamin D, eleutherococcus, iron and zinc. Each substance aids the body’s defense against disease by increasing its ability to fight infections and promoting the normal function of the body’s immune system.

Muscle function

Improved muscle function is facilitated by a range of nutrients, including vitamin D, carnitine, arginine and magnesium, helping to provide oxygen and energy to the muscles, supporting their contraction.

Antioxidant function

Antioxidant function is assisted by the presence of vitamin E, coenzyme Q10, vitamin C, selenium, zinc, tocotrienols and lycopene. These nutrients protect cells from what is known as oxidative stress, which is caused by free radicals, including reactive oxygen species (ROS).

As free radicals can attack cellular elements, they can cause irreparable damage, leading to diseases or cell death.

Energizing function

Energizing function is assisted by the following nutrients: taurine, vitamin B1, vitamin B3, ginseng, coenzyme Q10 and biotin (vitamin B7). Research has indicated that taurine can:

  • Allow for improved oxygenation
  • Inhibit the accumulation of lactic acid in the muscles
  • Preserve proper muscle contractility, even during intense exercise
  • Increase cardiac contractility during exercise

Ginseng appears to possess an “anti-fatigue” effect and reduces mental fatigue. The B complex group of vitamins are concerned with energy metabolism and, if utilized in the correct doses, can stimulate physiological functions by decreasing tiredness and mental and physical fatigue.

It is important to note that minerals within Apportal®, including zinc, iron, iodine, magnesium and selenium are in Sucrosomial® form, an innovative technology patented by Pharmanutra S.p.a.

The mineral is protected inside a matrix of phospholipids and saccharic esters of fatty acids, allowing high absorption and exceptional gastrointestinal toleration.

Discover how to fight physical and mental fatigue

Image Credit: PharmaNutra Spa

Apportal® is beneficial for a wide range of people in a variety of instances, such as:

  • Those in post-flu recovery
  • Those with recurrent episodes of tiredness and fatigue
  • Those seeking a quick recovery of the energy levels
  • Those suffering weakness or symptoms of asthenia
  • Those with poor or nutrient-deficient diets
  • Those who engage in regular and intense physical activity

Use in chronic Post-COVID-19 Fatigue (Post-COVID or Long-COVID syndrome)

Research in Italy followed approximately 200 patients diagnosed with this syndrome who were advised to take Apportal® for 28 consecutive days.1 Their degree of tiredness and quality of life were recorded on three occasions during the wholly observational study.

Specific questionnaires were utilized to collect patient data: the EuroQol-5D was employed to assess the level of patient health in general, the FACIT-Fatigue was utilized to quantify the degree of fatigue, and the Chalder Fatigue Scale was used to score the degree of mental fatigue.

Measurements were taken at three points; before commencing the Apportal® supplement, at 14 days and finally at 28 days from the initial daily intake of Apportal®.

The results indicated a considerable improvement in questionnaire scores at the day 14 and day 28 marks of supplementation with Apportal®.

The improvement observed at the 14-day point indicated that the positive effect is not just attributable to the time elapsed since the end of the disease but also as a result of the treatment itself and is statistically significant.

Benefits derived from Apportal® indicated an improvement in chronic asthenia in 90% of patients at the 28-day treatment marker.


1. M.S. Rossato; et al. “Observational study on the benefit of a nutritional supplement, supporting immune function and energy metabolism, on chronic fatigue associated with the SARS-CoV-2 post-infection progress”. Clin Nutr ESPEN. 2021 Dec;46:510-518. doi: 10.1016/j.clnesp.2021.08.031

About PharmaNutra S.p.A.

Founded and led by the President Andrea Lacorte and Vice President Roberto Lacorte, PharmaNutra was established in 2003. It develops unique nutritional supplements and innovative medical devices, handling the entire production process, from proprietary raw materials to the finished product. The effectiveness of its products is documented by considerable scientific proof, including 135 publications. The Group distributes and sells its products in Italy and abroad. In Italy, products are sold through a network of 160 Pharmaceutical Representatives serving doctors and also exclusively selling PharmaNutra products to pharmacies throughout Italy. Products are sold in over 60 countries abroad, through 41 partners selected from among the finest pharmaceutical companies. PharmaNutra leads the market in the production of iron-based nutritional supplements under the SiderAL® brand, where it boasts a number of important patents on Sucrosomial® technology. Over the years, the Group has developed a precise strategy for the management and production of intellectual property, founded on the integrated management of all the various elements: proprietary raw materials, patents, brands and clinical evidence.

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Last updated: Apr 4, 2022 at 5:51 AM


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