Major Depressive Disorder News and Research

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Major Depressive Disorder (MDD) is a psychiatric condition characterized by depressed mood or anhedonia (significant loss of interest or pleasure). The condition affects more than 15.7 million adults and approximately 3 million adolescents (aged 13 to 17 years) in the USA each year.

Effects of 10 commonly prescribed second-generation antidepressants studied

Because clinical depression is so disabling and affects more than 16 percent of adults in the United States at some time in their lives, researchers have worked hard to develop more effective treatments. But how much better are the newer pharmaceuticals?

21 Sep 2005

Depression improved during telephone therapy in multiple sclerosis patients

Patients with multiple sclerosis showed significant improvement in their depression during 16 weeks of telephone-administered psychotherapy treatment, according to an article in the September issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

5 Sep 2005

Vagus nerve stimulation (VNS) therapy for treatment-resistant depression proves effective for some patients

Vagus nerve stimulation (VNS) therapy, a treatment recently approved by the Food and Drug Administration for treatment-resistant depression, produced a positive response in more than 25 percent of patients in a national, yearlong study led by UT Southwestern Medical Center psychiatrists

31 Aug 2005

Some medical conditions increase risk for developing major depression while others do not

Those who feel sad and lack an interest in regular life activities for at least two weeks and qualify for a diagnosis of minor depression are six times as likely to develop major depression compared to those who don't have these symptoms, according to a longitudinal study on risks for depression.

22 Aug 2005

Cognitive therapy can have a preventive effect for depression

Three years ago, Terry Tuton was laid off from his job as project manager at a large technology firm, leaving him limited insurance coverage at a time when he was suffering from overpowering feelings of hopelessness and depression - and not for the first time in his life.

4 Aug 2005

FDA approval for VNS Therapy will help people with epilepsy

The U.S. Food and Drug Administration's recent approval of Vagus Nerve Stimulation Therapy for treatment of chronic depression provides a novel single-treatment option for two major symptoms suffered by people with epilepsy.

21 Jul 2005

Five basic steps to help doctors identify and treat insomnia in elderly patients

Researchers outline five basic steps to help doctors identify and treat insomnia in elderly patients. This article is published in a special insomnia themed supplement of the Journal of the American Geriatrics Society.

14 Jul 2005

GlaxoSmithKline announces availability of Paxil CR to U.S. market

GlaxoSmithKline announced today the availability of Paxil CR (paroxetine hydrochloride controlled release) tablets in pharmacies across the United States. Other markets will follow shortly thereafter.

27 Jun 2005

Bipolar disorder more prevalent and costly than believed

The incidence of bipolar disorder in the general population is considerably higher than earlier studies have indicated, resulting in significantly less productivity and more days lost from work compared to the better known major depressive disorder, according to preliminary findings from a national survey presented today at the Sixth International Conference on Bipolar Disorder.

19 Jun 2005

Newly developed treatment for severe grief shown more effective than standard therapy

A recently developed method for treating complicated grief, which includes discussing certain aspects of the death of a loved one, was found more effective than a standard therapy for depression, according to a study in the June 1 issue of JAMA.

25 May 2005

Investigational device-based therapies will lead to entirely new treatment options for chronic depression sufferers

Researchers said that developing brain stimulation techniques such as transcranial magnetic stimulation (TMS), vagal nerve stimulation and deep brain stimulation are emerging as significant treatment options for the millions of patients "poorly served" by existing therapies.

23 May 2005

Magnetic stimulation treatment for depression

Barbara Baas ran away from home and tried to kill herself as a teenager. As an adult, she has tried more than 15 varieties of antidepressants. But, thanks to a new weapon, she has finally reached a truce in a 45-year battle.

10 May 2005

Does clinical depression bring about chronic pain? Or does pain lead to depression?

Does clinical depression bring about chronic pain? Or does pain lead to depression? Because these two conditions frequently co-exist--30 to 54 percent of patients with major depressive disorder also suffer persistent physical pain--there has been much speculation about whether one causes the other or whether a common underlying factor provokes both. Results of studies into the precise nature of this relationship, however, have been inconsistent.

5 May 2005

Do life events precede the onset of heart attacks?

A group of researchers of the University of Bologna (headed by Dr Chiara Rafanelli) has verified in a controlled study whether heart attacks are preceded by stressful life circumstances.

23 Apr 2005

Cognitive therapy may be as effective as antidepressant medications in the initial treatment of moderate to severe major depression

Cognitive therapy, when provided by an experienced therapist, may be as effective as antidepressant medications in the initial treatment of moderate to severe major depression, according to an article in the April issue of Archives of General Psychiatry.

4 Apr 2005

New method of organising care for adults in the UK who suffer from clinical depression

Researchers at the University of York are investigating a new method of organising care for some of the three million adults in the UK who suffer from clinical depression.

6 Mar 2005

Premenstrual exacerbation of depression common

Virginia Commonwealth University mental health experts have found that women with depression commonly report fluctuations in their symptoms across the menstrual cycle — a key factor that may help physicians better evaluate and treat depressed women.

30 Jan 2005

Exercise reduces depression

Jumping on that treadmill or bike is not only good for one's health, but also can help significantly reduce depression, researchers at UT Southwestern Medical Center have found.

25 Jan 2005

Memory problems could be a clue to psychosis

University of Melbourne researchers have identified a variety of intellectual impairments, such as difficulties young people have in remembering new information, that could be a marker for later psychosis.

18 Jan 2005

Macular degeneration patients benefit from self-management training

A 12-hour self-management program for individuals with advanced age-related macular degeneration (AMD) leads to lasting improvements in mood and function, especially in depressed patients, and decreases the development of clinical depression in AMD patients over time, according to a University of California, San Diego (UCSD) Shiley Eye Center study published in the January 2005 Archives of Ophthalmology.

10 Jan 2005