DNA Damage News and Research

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New PCNA inhibitor AOH1996 shows selective cancer cell killings and tumor suppression potential

Study described a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) that selectively kills cancer cells.

4 Aug 2023

Recent advances in the understanding of the role and mechanism of CCAR2 in cancer

Researchers described the dual role of cell cycle and apoptosis regulator 2 (CCAR2) in cancer progression as a tumor suppressor and promoter.

4 Aug 2023

Study uncovers the science behind the body's tanning process after leaving the beach

Beachgoers are familiar with the experience of spending hours in the sun, going home, and noticing only hours later that their skin has changed color.

3 Aug 2023

The effects of oxidative stress on women’s fertility

Scientists review existing literature to assess the relationship between oxidative stress and female infertility.

1 Aug 2023

Two new compounds can block cancer cell’s escape route

Cancer cells are capable of escaping chemotherapy and radiotherapy by activating a signaling pathway that prevents them from dying.

27 Jul 2023

Combination therapy shows promise in treating advanced ER+ breast cancer

Advanced estrogen receptor-positive (ER+) breast cancer can be especially difficult to treat. A new study by researchers at Dartmouth Cancer Center led by Todd W. Miller, PhD, shows promise in using a combination of estrogen and a PARP inhibitor (a drug that suppresses DNA damage repair), to treat this type of cancer.

13 Jul 2023

New study reveals how lung tumors develop drug resistance

Cancer therapies that target specific genetic abnormalities in tumors have revolutionized treatment possibilities over the past two decades.

13 Jul 2023

Overdosed gene on chromosome 21 accelerates aging in people with Down's syndrome

An overdosed gene on chromosome 21 causes people with Down's Syndrome to age faster than the general population.

12 Jul 2023

Smoking and HPV found to increase risk of head and neck cancer

Tobacco smoking and human papillomavirus (HPV) are both well-known risk factors for head and neck cancer, but there is ample evidence to show they can interact to increase still further the risk of contracting the disease, according to a study by scientists at the University of São Paulo (USP) in Brazil and the University of Chile.

3 Jul 2023

Cyanotriazole compounds can selectively and rapidly kill trypanosome parasites, study shows

Cyanotriazole compounds are fast-acting topoisomerase II poisons that can selectively and rapidly kill trypanosome parasites that cause Chagas disease and African sleeping sickness, according to a new study.

29 Jun 2023

Is there an association between muscle-building supplements and DNA damage in resistance training practitioners?

A recent study investigated whether muscle-building supplements are associated with DNA damage in individuals practicing resistance training.

27 Jun 2023

New study warns of dangers of gene editing in human embryos

Scientists have discovered that the cells of early human embryos are often unable to repair damage to their DNA.

26 Jun 2023

New embryonic cell type that self-destructs to protect the developing fetus discovered

Scientists studying gene activity data of the early human embryo have discovered an overlooked type of cell which self-destructs within days of forming, as part of a quality control process to protect the developing fetus.

20 Jun 2023

Does taurine deficiency speed up aging?

The association of the amino acid taurine with aging.

16 Jun 2023

Study reveals impressive skin benefits of blueberries

The benefits of topical and dietary blueberry supplementation in preventing environmental stressor-mediated skin damage and preserving skin health.

14 Jun 2023

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex."

13 Jun 2023

Heat-damaged DNA in food may contribute to genetic risks

Researchers have newly discovered a surprising and potentially significant reason why eating foods frequently cooked at high temperatures, such as red meat and deep-fried fare, elevates cancer risk. The alleged culprit: DNA within the food that's been damaged by the cooking process.

13 Jun 2023

Analyzing the role of LP-284 Hodgkin's lymphoma models and in DNA damage repair

A new research paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, "LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair."

13 Jun 2023

Fred Hutch experts highlight research on cancer treatment advances, survivorship and precision oncology at ASCO

At the 2023 American Society for Clinical Oncology Annual Meeting—to be held June 2-6 in Chicago, Illinois—Fred Hutchinson Cancer Center experts will present research spanning survivorship, advances in treatments and clinical trials, how access to cancer care affects outcomes, integrative medicine and more.

5 Jun 2023

Study sheds light on metabolic enzymes and processes essential for DNA damage repair

In crisis, the nucleus calls antioxidant enzymes to the rescue. The nucleus being metabolically active is a profound paradigm shift with implications for cancer research.

1 Jun 2023

DNA Damage News and Research

New PCNA inhibitor AOH1996 shows selective cancer cell killings and tumor suppression potential

Recent advances in the understanding of the role and mechanism of CCAR2 in cancer

Study uncovers the science behind the body's tanning process after leaving the beach

The effects of oxidative stress on women’s fertility

Two new compounds can block cancer cell’s escape route

Combination therapy shows promise in treating advanced ER+ breast cancer

New study reveals how lung tumors develop drug resistance

Overdosed gene on chromosome 21 accelerates aging in people with Down's syndrome

Smoking and HPV found to increase risk of head and neck cancer

Cyanotriazole compounds can selectively and rapidly kill trypanosome parasites, study shows

Is there an association between muscle-building supplements and DNA damage in resistance training practitioners?

New study warns of dangers of gene editing in human embryos

New embryonic cell type that self-destructs to protect the developing fetus discovered

Does taurine deficiency speed up aging?

Study reveals impressive skin benefits of blueberries

Regulatory connection between DREAM and cellular senescence may play a potential role in aging process

Heat-damaged DNA in food may contribute to genetic risks

Analyzing the role of LP-284 Hodgkin's lymphoma models and in DNA damage repair

Fred Hutch experts highlight research on cancer treatment advances, survivorship and precision oncology at ASCO

Study sheds light on metabolic enzymes and processes essential for DNA damage repair

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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