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Amgen plows ahead with costly, highly toxic cancer dosing despite FDA challenge

When doctors began using the drug sotorasib in 2021 with high expectations for its innovative approach to attacking lung cancer, retired medical technician Don Crosslin was an early beneficiary.

7 May 2024

New diagnostic and treatment approach could revolutionize bladder cancer care

A new diagnostic and treatment approach for bladder cancer will undergo a clinical trial in Queensland.

6 May 2024

Mindfulness training reduces dropout rates and relapses in opioid addiction treatment

Supplementing standard opioid addiction treatment with Mindfulness Oriented Recovery Enhancement (MORE) -; an intervention that incorporates mindfulness training, savoring skills, and cognitive reappraisal -; cuts program dropout rates by 59 percent and relapses by 42 percent, according to Rutgers-led research.

6 May 2024

CRISPR-based gene editing shows promise in treating rare form of blindness

About 79% of clinical trial participants experienced measurable improvement after receiving experimental, CRISPR-based gene editing that is designed to fix a rare form of blindness, according to a paper published in the New England Journal of Medicine.

6 May 2024

MedStar Washington Hospital Center enrolls first U.S. patient in gene-editing therapy trial for heart disease

The first U.S. heart patient involved in a study for a new gene-editing therapy directly infused inside the body has successfully been enrolled at MedStar Washington Hospital Center.

6 May 2024

CRISPR gene editing shows promise for treating individuals with a form of inherited blindness

Results from a groundbreaking clinical trial of CRISPR gene editing in 14 individuals with a form of inherited blindness show that the treatment is safe and led to measurable improvements in 11 of the participants treated.

6 May 2024

Study sheds light on the promising role of virtual reality in treating depression

A new study published in JMIR Mental Health sheds light on the promising role of virtual reality (VR) in treating major depressive disorder (MDD).

6 May 2024

Plant-based medication may be an effective therapy to help people quit vaping

Eleven million U.S. adults use e-cigarettes to vape nicotine, and about half of them say that they want to stop, but many have trouble doing so because nicotine is an addictive drug.

6 May 2024

Study identifies APOE4 homozygotes as high-risk group for Alzheimer's disease

Researchers from the Research Area on Neurological Diseases, Neuroscience, and Mental Health at the Sant Pau Research Institute, led by Dr. Juan Fortea, Director of the Memory Unit of the Neurology Service at the same hospital, have found that over 95% of individuals over 65 years old who have two copies of the APOE4 gene -APOE4 homozygotes- show biological characteristics of Alzheimer's pathology in the brain or biomarkers of this disease in cerebrospinal fluid and PET scans.

6 May 2024

Durable lymph-node expansion improves vaccine responses against tumors

Each one of us has around 600 lymph nodes (LNs) – small, bean-shaped organs that house various types of blood cells and filter lymph fluid – scattered throughout our bodies.

6 May 2024

Genomics plc and GSK collaborate to harness polygenic risk scores in clinical trials

Genomics plc and GSK announced a new collaboration to explore the potential for using polygenic risk scores (PRS) in clinical trials, to improve understanding of disease risk and patient selection, which could support optimization of trial design.

6 May 2024

NK cells' role in cancer therapy resistance unveiled

Activated T cells that carry a certain marker protein on their surface are controlled by natural killer (NK) cells, another cell type of the immune system.

3 May 2024

Study supports the consideration of 177Lu-PSMA-617 as new standard treatment for metastatic prostate cancer

In a follow-on analysis of results from the phase 3 PSMAfore study, clinical investigators from Dana-Farber and elsewhere found that clinical outcomes consistently favored 177Lu-PSMA-617 over a change from one androgen receptor pathway inhibitor (ARPI) to another, regardless of which ARPI patients received first.

3 May 2024

Investigating fertilized ACL surgery's impact on return to play in athletes

The Marshall University Joan C. Edwards School of Medicine is now accepting applicants for an observational trial focused on fertilized anterior cruciate ligament (ACL) reconstruction.

2 May 2024

AI model mimics randomized clinical trials for determining optimal stroke prevention treatment

Scientists have designed a new artificial intelligence model that emulates randomized clinical trials at determining the treatment options most effective at preventing stroke in people with heart disease.

2 May 2024

Study reveals molecular changes in 19 organs due to exercise

The health benefits of exercise are well known but new research shows that the body's response to exercise is more complex and far-reaching than previously thought.

2 May 2024

First FDA-approved cellular therapy for metastatic melanoma available in South Florida

Patients in South Florida with metastatic melanoma will soon have access to the first cellular therapy for this advanced form of skin cancer, following its recent approval by the Food and Drug Administration (FDA).

2 May 2024

Study reveals survival benefit from genome-matched cancer treatments in rural Maine

In 2016, The Jackson Laboratory (JAX), a National Cancer Institute-designated Cancer Center and at the forefront of cancer research, launched the Maine Cancer Genomics Initiative (MCGI) to bring the latest progress in cancer care to rural Maine patients.

1 May 2024

AI-enabled ECG system significantly reduces hospital mortality rates by identifying at-risk patients

A study in Nature Medicine evaluated an AI-enabled electrocardiogram (ECG) system's ability to identify hospitalized patients at risk of death, demonstrating its effectiveness in reducing mortality by enhancing the rapid response systems (RRS) through real-time alerts and risk stratification.

30 Apr 2024

Garvan Institute and Illumina collaborate to transform the treatment of complex diseases

Illumina, a global genomics and human health company, has partnered with the Garvan Institute of Medical Research's TenK10K project to help transform the treatment of complex diseases, starting with autoimmune diseases, with a joint investment of $27 million AUD.

30 Apr 2024

Clinical Trial News and Research

Amgen plows ahead with costly, highly toxic cancer dosing despite FDA challenge

New diagnostic and treatment approach could revolutionize bladder cancer care

Mindfulness training reduces dropout rates and relapses in opioid addiction treatment

CRISPR-based gene editing shows promise in treating rare form of blindness

MedStar Washington Hospital Center enrolls first U.S. patient in gene-editing therapy trial for heart disease

CRISPR gene editing shows promise for treating individuals with a form of inherited blindness

Study sheds light on the promising role of virtual reality in treating depression

Plant-based medication may be an effective therapy to help people quit vaping

Study identifies APOE4 homozygotes as high-risk group for Alzheimer's disease

Durable lymph-node expansion improves vaccine responses against tumors

Genomics plc and GSK collaborate to harness polygenic risk scores in clinical trials

NK cells' role in cancer therapy resistance unveiled

Study supports the consideration of 177Lu-PSMA-617 as new standard treatment for metastatic prostate cancer

Investigating fertilized ACL surgery's impact on return to play in athletes

AI model mimics randomized clinical trials for determining optimal stroke prevention treatment

Study reveals molecular changes in 19 organs due to exercise

First FDA-approved cellular therapy for metastatic melanoma available in South Florida

Study reveals survival benefit from genome-matched cancer treatments in rural Maine

AI-enabled ECG system significantly reduces hospital mortality rates by identifying at-risk patients

Garvan Institute and Illumina collaborate to transform the treatment of complex diseases

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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