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Research reveals new insights into the role of efferocytosis in pancreatic cancer liver metastasis

A research paper published today (14 February 2024) in Nature Cancer details new insights into the role of efferocytosis – the burying of dead cells – in pancreatic cancer that spreads to the liver.

14 Feb 2024

Understanding how natural genetic variation contributes to adaptive responses to low oxygen

Humans are still evolving, and Tatum Simonson, PhD, founder and co-director of the Center for Physiological Genomics of Low Oxygen at University of California School of Medicine, plans to use evolution to improve healthcare for all.

12 Feb 2024

New treatment targeting aging cells could offer lasting relief for diabetic macular edema

Targeting senescent cells in the retina with a BCL-xL inhibitor shows promise as a durable treatment for diabetic macular edema, potentially offering long-term visual function improvements.

8 Feb 2024

New study maps the broad spectrum of neurodiversity with innovative model

A JCCP Advances study introduces a new model to understand the broad spectrum of neurodiversity, revealing that individual traits can span across multiple neurodevelopmental conditions, offering a more nuanced approach to neurodiversity.

8 Feb 2024

Monash-led study unveils potential long-term treatment for lupus

Researchers assessed Smith (Sm)-specific regulatory T cells (Tregs) efficacy in halting lupus nephritis (LN) by engineering and testing epitope-targeted Tregs for systemic lupus erythematosus (SLE) treatment.

8 Feb 2024

Resveratrol can combat Alzheimer's via inflammatory suppression, study shows

Study demonstrates Resveratrol's ability to mitigate Alzheimer's Disease (AD) symptoms by inhibiting proinflammatory responses and promoting antioxidant enzyme expression in microglial cell lines, offering insights into its neuroprotective mechanisms.

5 Feb 2024

Study sheds light on 7-DHC's potential to induce cell death-resistant state in tumors

Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis (a form of programmed cell death) has emerged not only as a focal point of research for its potential in eliminating cancer cells, but also its role in a plethora of other diseases, including neurodegenerative diseases such as Alzheimer's disease, eye diseases such as Retinitis pigmentosa and age-related macular degeneration, as well as ischemia, cardiovascular disease, liver disease, acute kidney injury and inflammation.

1 Feb 2024

Specific epigenetic pathway found to be involved in the development of melanoma drug resistance

One of the major challenges in cancer research and clinical care is understanding the molecular basis for therapeutic resistance as a major cause of long term treatment failures.

1 Feb 2024

Gut microbiome may hold key to fighting common respiratory viruses

The composition of microbiota found in the gut influences how susceptible mice are to respiratory virus infections and the severity of these infections, according to researchers from the Center for Translational Antiviral Research in the Institute for Biomedical Sciences at Georgia State University.

30 Jan 2024

New review aims to help clinicians diagnose and manage PCOS

A recent review article in CMAJ explores the state of current knowledge on the diagnosis and treatment of this chronic disorder.

30 Jan 2024

Revolutionary CAR T-cell therapy shows promise in reversing age-related metabolic dysfunction

study evaluates senolytic CAR T-cell therapy targeting uPAR-positive cells in aged mice, showing its effectiveness in mitigating age-related metabolic dysfunction and offering a potential long-lasting treatment for aging-associated conditions.

28 Jan 2024

Study uncovers 23 new genetic markers linked to kidney health on the X-chromosome

A meta-analysis of 908,697 samples to investigate the genetic, sex-dependent basis of kidney traits.

23 Jan 2024

Long COVID's impact on cardiovascular health: what we do and do not know

Researchers review the cardiovascular effects of long COVID.

23 Jan 2024

The role of glucose in inducing tolerance to amphotericin B for fungal meningitis treatment

Researchers investigate the mechanism responsible for amphotericin B tolerance of Cryptococcus neoformans.

18 Jan 2024

Review of traditional treatments and novel nutritional interventions for sickle cell disease

Nutrition-related studies involving sickle cell disease (SCD) patients, particularly those in Africa.

17 Jan 2024

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

This new article publication from Acta Pharmaceutica Sinica B, discusses how GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis.

15 Jan 2024

Immune dysregulation in long COVID patients uncovered in new study

Sstudy reveals significant immune changes in long COVID patients, including altered T cell responses and systemic inflammation, using advanced 'omics' and serological assays.

14 Jan 2024

3D nanomatrix vascular sheet model for high-throughput atherosclerosis drug testing

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

12 Jan 2024

Groundbreaking study uncovers hundreds of genetic markers linked to insulin resistance

A genome-wide study of 402,398 individuals identifies 369 SNPs associated with insulin resistance, offering insights into metabolic diseases and potential therapeutic targets.

11 Jan 2024

Study identifies distinct CD4+ T cell changes in various autoimmune diseases

Much like ripples on the water can betray powerful currents below the surface, small changes in our bodies can sometimes be an indicator of a serious condition.

11 Jan 2024

Phenotype News and Research

Research reveals new insights into the role of efferocytosis in pancreatic cancer liver metastasis

Understanding how natural genetic variation contributes to adaptive responses to low oxygen

New treatment targeting aging cells could offer lasting relief for diabetic macular edema

New study maps the broad spectrum of neurodiversity with innovative model

Monash-led study unveils potential long-term treatment for lupus

Resveratrol can combat Alzheimer's via inflammatory suppression, study shows

Study sheds light on 7-DHC's potential to induce cell death-resistant state in tumors

Specific epigenetic pathway found to be involved in the development of melanoma drug resistance

Gut microbiome may hold key to fighting common respiratory viruses

New review aims to help clinicians diagnose and manage PCOS

Revolutionary CAR T-cell therapy shows promise in reversing age-related metabolic dysfunction

Study uncovers 23 new genetic markers linked to kidney health on the X-chromosome

Long COVID's impact on cardiovascular health: what we do and do not know

The role of glucose in inducing tolerance to amphotericin B for fungal meningitis treatment

Review of traditional treatments and novel nutritional interventions for sickle cell disease

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

Immune dysregulation in long COVID patients uncovered in new study

3D nanomatrix vascular sheet model for high-throughput atherosclerosis drug testing

Groundbreaking study uncovers hundreds of genetic markers linked to insulin resistance

Study identifies distinct CD4+ T cell changes in various autoimmune diseases

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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