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What is the ‘immune self,’ and how can this concept benefit immunological research?

A perspective review discusses the concept of the 'immune self' and how adaptive immune responses are influenced by self-similarity. The study emphasizes advances and challenges in defining self-similarity and its impact on immunological research.

13 May 2024

Western diet linked to chronic diseases by gut microbiota disruption

The Western diet disrupts gut microbiota and gut barrier function, increasing the risk of non-communicable chronic diseases through chronic low-grade inflammation.

13 May 2024

Obesity, metabolic syndrome impact breast cancer subtypes and mortality

In the Women's Health Initiative (WHI) randomized trial, a low-fat diet reduced breast cancer mortality, especially in women with more metabolic syndrome (MetS) components (obesity, high blood pressure, elevated blood sugar, and abnormal cholesterol).

13 May 2024

Aerobic exercise proves most effective for combating obesity-related inflammation

New research being presented at this year's European Congress on Obesity (ECO) in Venice, Italy (12-15 May), reveals the anti-inflammatory power of moderate-to-vigorous aerobic exercise in adults living with the low-grade inflammation of obesity, shedding light on its potential to help prevent multiple metabolic diseases including type 2 diabetes and atherosclerosis (clogged arteries).

13 May 2024

Researchers discover a 'training program' driving parietal cell development

Common conditions such as indigestion and heartburn as well as peptic ulcers, autoimmune gastritis and stomach and esophageal cancers have one thing in common – they involve disruptions of the normal activity of parietal cells (PCs) in the stomach, the only cells in the body that produce acid.

10 May 2024

Innovative "smart" contact lens may revolutionize glaucoma detection and monitoring

Most people with early-stage glaucoma don't know they have it, even though early treatment is key to reducing vision loss.

9 May 2024

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have pinpointed a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas, an aggressive type of brain tumor that is fast growing and difficult to treat.

9 May 2024

Enhancing the ability of natural killer cells to combat hematologic malignancies

A new study reveals a groundbreaking approach to immunotherapy, demonstrating that blocking the interaction between the CD300A receptor and phosphatidylserine (PS) significantly enhances the ability of human natural killer (NK) cells to lyse hematologic malignancies (HMs).

9 May 2024

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

Researchers developed bispecific antibodies targeting both the N-terminal and receptor binding domains of SARS-CoV-2, demonstrating significant neutralization across various Omicron variants, suggesting potential for new COVID-19 treatments.

9 May 2024

USC study unveils iron as key driver of lung inflammation in allergic asthma

New USC research shows that iron serves as a gas pedal driving certain immune cells that cause inflammation in the lungs during an allergic asthma attack – and blocking or limiting iron may reduce the severity of symptoms.

8 May 2024

Researchers enhance CAR-T cells to target solid tumors

Researchers at the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center (MECCC) have shown that a breakthrough therapy for treating blood cancers can be adapted to treat solid tumors-;an advance that could transform cancer treatment.

8 May 2024

Study shows cows harbor both human and avian flu receptors in their mammary glands

Study investigates the expression of influenza A virus (IAV) receptors in bovine respiratory, cerebral, and mammary tissues, revealing significant localization of human and duck receptors in mammary glands and predominant chicken receptors in the respiratory tract, which may influence the transmission and pathogenesis of IAV in cattle.

8 May 2024

New Quartet nanocage vaccine shows promise against coronavirus variants

Researchers have developed a novel vaccination approach using Quartet nanocages that display receptor-binding domains (RBDs) from different sarbecoviruses, showing enhanced immune responses and potential protection against diverse coronavirus strains including SARS-CoV-2 and its variants.

8 May 2024

Vitamin D receptor polymorphism found to influence COVID-19 severity

Researchers compared SNPs in the vitamin D receptor (VDR) gene between mild and severe COVID-19 patients.

7 May 2024

Case study: Cannabis might dampen the pain, but amplify the psychosis!

Case study details a 27-year-old woman with schizoaffective disorder and fibromyalgia who used high-potency cannabis to alleviate pain but experienced adverse psychiatric effects. A month-long diet lowering free glutamate improved her pain, mental health, and allowed her to quit cannabis, highlighting the risks of cannabis self-medication for pain management.

7 May 2024

Neural circuits revealed as key regulators in body's immune response, study finds

A recent study in Nature reveals how specific neural circuits within the body-brain axis regulate immune responses, highlighting potential new therapeutic approaches for immune disorders.

6 May 2024

Long-term impact of COVID-19 on body composition explored

COVID-19 may also affect body composition, even in those who did not acquire the infection.

5 May 2024

Natural compounds in gut microbiome show promise for inflammation treatment

Researchers at the University of Toronto have found naturally occurring compounds in the gut that can be harnessed to reduce inflammation and other symptoms of digestive issues.

3 May 2024

Novel vaccine approach targets AML and other blood cancers

Acute myeloid leukemia (AML) is a type of blood cancer that forms in the soft marrow of the bones, typically attacking cells that would otherwise form the key component of the body's immunodefense system, white blood cells.

3 May 2024

Study supports the consideration of 177Lu-PSMA-617 as new standard treatment for metastatic prostate cancer

In a follow-on analysis of results from the phase 3 PSMAfore study, clinical investigators from Dana-Farber and elsewhere found that clinical outcomes consistently favored 177Lu-PSMA-617 over a change from one androgen receptor pathway inhibitor (ARPI) to another, regardless of which ARPI patients received first.

3 May 2024

Receptor News and Research

What is the ‘immune self,’ and how can this concept benefit immunological research?

Western diet linked to chronic diseases by gut microbiota disruption

Obesity, metabolic syndrome impact breast cancer subtypes and mortality

Aerobic exercise proves most effective for combating obesity-related inflammation

Researchers discover a 'training program' driving parietal cell development

Innovative "smart" contact lens may revolutionize glaucoma detection and monitoring

Combination immunotherapy treatment enhances immune response for people with malignant gliomas

Enhancing the ability of natural killer cells to combat hematologic malignancies

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

USC study unveils iron as key driver of lung inflammation in allergic asthma

Researchers enhance CAR-T cells to target solid tumors

Study shows cows harbor both human and avian flu receptors in their mammary glands

New Quartet nanocage vaccine shows promise against coronavirus variants

Vitamin D receptor polymorphism found to influence COVID-19 severity

Case study: Cannabis might dampen the pain, but amplify the psychosis!

Neural circuits revealed as key regulators in body's immune response, study finds

Long-term impact of COVID-19 on body composition explored

Natural compounds in gut microbiome show promise for inflammation treatment

Novel vaccine approach targets AML and other blood cancers

Study supports the consideration of 177Lu-PSMA-617 as new standard treatment for metastatic prostate cancer

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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