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Protein mechanics key to cell nucleus entry, study finds

Researchers at the Francis Crick Institute and King's College London have discovered that how soft or rigid proteins are in certain regions can dictate how fast or slow they enter the nucleus.

13 May 2024

New insights into Chaga mushroom's mechanisms for fighting oral cancer

The mechanisms behind the anti-tumor activity of Chaga mushroom extracts in HSC-4 human oral cancer cells.

13 May 2024

Perspective delves into the rising threat of the MPX virus

Scientist at NIAID reviews the escalating global prevalence of the MPX virus, detailing its biology and transmission modes, and the urgent need for comprehensive research to understand and control its spread effectively.

13 May 2024

New modular epigenome editing platform sheds light on gene regulation mechanisms

Understanding how genes are regulated at the molecular level is a central challenge in modern biology.

9 May 2024

Clinical trial shows CRISPR gene editing has exciting potential to treat a rare form of blindness

A recent study published in The New England Journal of Medicine investigated the potential use of gene editing to correct a congenital retinal degeneration called CEP290 that causes early-onset vision loss.

8 May 2024

Intermittent fasting halts liver disease progression and reduces cancer risk

Fatty liver disease often leads to chronic liver inflammation and can even result in liver cancer. Scientists from the German Cancer Research Center (DKFZ) and the University of Tübingen have now shown in mice that intermittent fasting on a 5:2 schedule can halt this development.

8 May 2024

Bacterial fatty acid metabolite identified as key player in immune regulation

Gut microbiota or the population of microbial inhabitants in the intestine, plays a key role in digestion and maintenance of overall health.-

7 May 2024

Herpesvirus infection alters structure and function of mitochondria in the host cell

Researchers at the University of Jyväskylä have found that herpesvirus infection modifies the structure and normal function of the mitochondria in the host cell.

7 May 2024

Vitamin D receptor polymorphism found to influence COVID-19 severity

Researchers compared SNPs in the vitamin D receptor (VDR) gene between mild and severe COVID-19 patients.

7 May 2024

Study reveals impact of Mediator protein complex on cell division regulation

Researchers at Umeå University, Sweden, have discovered that how a special protein complex called the Mediator moves along genes in DNA may have an impact on how cells divide.

3 May 2024

Breakthrough study identifies potential treatments for influenza-associated encephalopathy

It might start simply, with a cough or sneeze…but in some cases, the flu virus can make its way to your brain, causing serious symptoms or even death through a disease known as influenza-associated encephalopathy (IAE).

3 May 2024

Researchers identify key molecular alterations from endurance exercise that could combat chronic diseases

A whole-organism molecular map of the temporal effects of endurance training in rats.

3 May 2024

Study highlights the role of dynamic DNA structures in memory consolidation

An international collaborative research team, including scientists from UQ's Queensland Brain Institute (QBI), has discovered a novel mechanism underlying memory involving rapid changes in a specific DNA structure.

2 May 2024

New drug candidate reverses obesity in mice by transforming liver metabolism

A mitochondrial transcription inhibitor (IMT) shifted metabolism in high-fat diet mice toward fatty acid oxidation, leading to weight loss, reduced liver fat, and improved glucose tolerance.

1 May 2024

Deciphering the role of Th2-multipotent progenitor cells in chronic allergic inflammation

Currently, most therapies for allergic diseases require lifelong treatment. Allergic reactions, characterized by ongoing (type 2) inflammation in response to chronic antigen exposure, underlie many chronic diseases in humans, including asthma, atopic dermatitis, ulcerative colitis and more.

30 Apr 2024

Unlocking the mechanisms of pluripotent cell's fate determination

As embryos, all complex organisms are partially made up of pluripotent stem cells, a term for cells that have the capacity to differentiate into any kind of cell: nerve cells, muscle cells, blood cells, skin cells, and the like.

29 Apr 2024

Harnessing immune enhancement to combat drug-resistant tuberculosis

Experts are working on novel immune-enhancing therapies called host-directed therapies to use the body's own immune system to target tuberculosis, with hopes that they could tackle even the drug-resistant forms of the disease.

26 Apr 2024

Study suggests lingering coronavirus in tissues may contribute to long COVID symptoms

Study investigated whether SARS-CoV-2 lingers in tissues after COVID-19 recovery and if it's linked to long COVID symptoms. They found viral RNA in various organs, and its presence correlated with long COVID symptoms.

25 Apr 2024

Scientists identify signaling pathway in liver cells linked to fibrosis

A healthy liver filters all the blood in your body, breaks down toxins and digests fats. It produces collagen to repair damaged cells when the liver is injured.

25 Apr 2024

New research lays foundation for targeted therapies to inhibit NF-κB activation

A new paper by Dana-Farber Cancer Institute scientists lays the foundation for targeted therapies to inhibit activation of nuclear factor kappa B (NF-κB), a transcription factor that plays a role in various autoimmune and inflammatory diseases and cancers.

25 Apr 2024