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H5N1 avian flu strain jumps to seals in Quebec, raising zoonotic fears

Study describes the unusual mortality of gray and harbor seals in Quebec due to a highly pathogenic avian influenza A (H5N1) strain, raising concerns about potential zoonotic spillover.

17 May 2024

Investigating age-associated gene expression changes in mouse sweat glands

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "Characterization of age-associated gene expression changes in mouse sweat glands."

15 May 2024

New study reveals brain clearance of toxins is reduced during sleep and anesthesia

The adipose-neural axis plays an important role in arrhythmogenesis.

15 May 2024

Interactions between adipose and sympathetic neurons contribute to cardiac arrhythmia

A study in Cell Reports Medicine used an in vitro co-culture of adipocytes, cardiomyocytes, and sympathetic neurons to reveal that the adipose-neural axis plays a crucial role in arrhythmogenesis, driven by interactions between epicardial adipose tissue and the sympathetic nervous system.

14 May 2024

St. Jude researchers unveil mechanisms to block PXR and enhance drug potency

Deaths from cancer or infections can occur when available treatments are ineffective. Once turned on, pregnane X receptor (PXR) activates the expression of genes encoding enzymes that metabolize external chemicals, including drugs.

14 May 2024

Study proposes a novel therapeutic avenue for tackling EHF-induced cholangiocarcinogenesis

This study is led by Dr. Yiming Luo (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology) and Professor. Huifang Liang (Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology).

14 May 2024

Protein mechanics key to cell nucleus entry, study finds

Researchers at the Francis Crick Institute and King's College London have discovered that how soft or rigid proteins are in certain regions can dictate how fast or slow they enter the nucleus.

13 May 2024

New insights into Chaga mushroom's mechanisms for fighting oral cancer

The mechanisms behind the anti-tumor activity of Chaga mushroom extracts in HSC-4 human oral cancer cells.

13 May 2024

Perspective delves into the rising threat of the MPX virus

Scientist at NIAID reviews the escalating global prevalence of the MPX virus, detailing its biology and transmission modes, and the urgent need for comprehensive research to understand and control its spread effectively.

13 May 2024

New modular epigenome editing platform sheds light on gene regulation mechanisms

Understanding how genes are regulated at the molecular level is a central challenge in modern biology.

9 May 2024

Clinical trial shows CRISPR gene editing has exciting potential to treat a rare form of blindness

A recent study published in The New England Journal of Medicine investigated the potential use of gene editing to correct a congenital retinal degeneration called CEP290 that causes early-onset vision loss.

8 May 2024

Intermittent fasting halts liver disease progression and reduces cancer risk

Fatty liver disease often leads to chronic liver inflammation and can even result in liver cancer. Scientists from the German Cancer Research Center (DKFZ) and the University of Tübingen have now shown in mice that intermittent fasting on a 5:2 schedule can halt this development.

8 May 2024