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WHO update on Meningococcal disease in Central African Republic

As of 31 March 2004, WHO has received reports of 43 cases and 7 deaths in the Central African Republic.

8 Apr 2004

Rare Burkina Faso strain of meningitis under control

A rare strain of meningitis, which re-emerged recently in Burkina Faso, would have left health authorities helpless just two years ago. Now, thanks to two years of work orchestrated by the World Health Organization (WHO), the strain (known as W135) has been rapidly identified and a mass action campaign is now controlling the outbreak.

8 Apr 2004

New microgel could potentially recover any enzyme and save manufacturers considerable money

Carnegie Mellon University scientists have employed biological molecules to create a microgel that could recover costly enzymes for repeated use in catalyzing commercially important reactions. The microgel could potentially recover any enzyme and theoretically save manufacturers considerable money.

8 Apr 2004

Intensive diabetes management yields positive results

Increasing diabetes awareness and integrating a multi-faceted, approach to improve patient care and education, results in significantly improved patient outcomes, according to a report in the April issue of Clinical Diabetes, a publication of the American Diabetes Association.

7 Apr 2004

Protein kinase complex influences the outer layer of skin to control the eventual shape of the full-grown skeleton and skull

Continuing studies about an important regulatory protein kinase complex called I-kappa-B kinase (or IKK) have now shown that a subunit of IKK – IKK alpha – influences the outer layer of skin in developing mice to control the eventual shape of the full-grown skeleton and skull.

7 Apr 2004

Genetic trick makes gene therapy vectors more versatile

A genetic trick used by viruses to replicate themselves has been adapted for laboratory use to build complex protein structures required by immune system cells, according to investigators at St. Jude Children’s Research Hospital.

7 Apr 2004

Time-reversal acoustics research promises medical breakthroughs

Scientists have not yet found a way to actually make time run backward, but in the cutting-edge world of recent acoustics research, they have shown a way to make sound waves run backward in a kind of ultra-focused reverse echo. By the technology known as time-reversal acoustics, sound waves - in exact reverse order from the original sound - echo directly and very precisely back to their source point.

7 Apr 2004

Completion of the sequencing of human chromosome 19

The United States Department of Energy (DOE) Joint Genome Institute (JGI) and Stanford University report today the completion of the sequencing of human chromosome 19, the most gene-rich of all the human chromosomes. This achievement is described in the April 1, 2004 edition of the journal Nature.

7 Apr 2004

New method to induce embryonic stem cells to develop into bone marrow and blood cells

Researchers at Northwestern University have devised a method to induce embryonic stem cells to develop into bone marrow and blood cells. Injecting the stem cells into the bone marrow cavity of mice whose bone marrow cells had been depleted restored production of blood cells, including cells of the immune system, which normally are created in the bone marrow.

6 Apr 2004

A new technique for engineering protein crystals is helping scientists figure out the three-dimensional structures of some important biological molecules

A new technique for engineering protein crystals is helping scientists figure out the three-dimensional structures of some important biological molecules, including a key plague protein whose structure has eluded researchers until now. The technique, developed with support from the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health (NIH), promises to help pharmaceutical companies develop more effective drugs to treat various diseases by tailor-making molecules to "fit" a protein's shape.

6 Apr 2004

Scientists studying vaccinia virus, a relative of smallpox, have determined that a gene necessary for virus replication also has a key role in turning off inflammation

Scientists at the University of Illinois at Urbana-Champaign studying vaccinia virus, a close relative of smallpox, have determined that a gene necessary for virus replication also has a key role in turning off inflammation, a crucial anti-viral immune response of host cells.

6 Apr 2004

Ohio university to get major expansion cancer program

The Ohio State University Board of Trustees today has authorized the preparation of architectural and engineering plans for a possible major expansion of the university’s cancer program.

5 Apr 2004

NeoRx Corporation acquires worldwide rights to platinum-based anti-cancer agent

NeoRx Corporation today announced that it has acquired from AnorMED Inc. the worldwide exclusive rights, excluding Japan, to develop, manufacture and commercialize AMD473, a platinum-based anti-cancer agent. AMD473 has been administered to more than 500 cancer patients in phase I and phase II clinical trials, demonstrating anti-cancer activity in a wide range of tumors and a manageable safety profile. NeoRx expects to initiate clinical studies of AMD473 in one or more cancer indications in the second half of this year.

5 Apr 2004

New center enables genetic treatments and advances

A new state-of-the-art research facility dedicated to helping produce modified cells for treatment of cancer and other diseases recently opened at the Siteman Cancer Center.

1 Apr 2004

Compounds that may stop replication of T-cell leukemia virus

Researchers are analyzing several compounds that may inhibit the enzyme that is essential for the reproduction of the Human T-cell Leukemia Virus Type 1 (HTLV-I), which has infected 15 to 20 million people worldwide. The virus causes the fatal adult T-cell leukemia in up to 10 percent of those infected.

1 Apr 2004

Lab discovers way to keep short-lived catalysts active for longer than five months

Enzymes, the workhorses of chemical reactions in cells, lead short and brutal lives. They cleave and assemble proteins and metabolize compounds for a few hours, and then they are spent. This sad fact of nature has limited the possibilities of harnessing enzymes as catalytic tools outside the cell, in uses that range from biosensing to toxic waste cleanup.

1 Apr 2004

Scientists have discovered that a non-genetic molecular process can effect cell behaviour

Genetic mutations, sudden, random and usually harmful changes to the structure of a gene, are only one factor that determines the ultimate fate of a cell. Chicago scientists have discovered that a non-genetic molecular process also can play a role, and that experimenters can influence this process in bacteria, they report in the April 1 issue of the journal Nature.

1 Apr 2004

T-cells in lupus patients avoid apoptosis and are stimulated to produce antibodies against the patients own DNA

Researchers studying autoimmune diseases have found a molecular mechanism that explains how T-cells in lupus patients avoid apoptosis and are stimulated to produce antibodies against the patients own DNA.

1 Apr 2004

How rat's genetic blueprint stacks up against those of mice and humans

An international research team, supported by the National Institutes of Health (NIH), today announced it has completed a high-quality, draft sequence of the genome of the laboratory rat, and has used that data to explore how the rat's genetic blueprint stacks up against those of mice and humans.

31 Mar 2004

SARS virus vaccine stimulates protective immune response

An experimental vaccine prevents the SARS virus from replicating in laboratory mice, according to a new report in the April 1 issue of Nature. Scientists at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health, developed the vaccine. The vaccine was tested in a mouse model of SARS infection recently validated by other NIAID investigators.

31 Mar 2004

Laboratory News and Research

WHO update on Meningococcal disease in Central African Republic

Rare Burkina Faso strain of meningitis under control

New microgel could potentially recover any enzyme and save manufacturers considerable money

Intensive diabetes management yields positive results

Protein kinase complex influences the outer layer of skin to control the eventual shape of the full-grown skeleton and skull

Genetic trick makes gene therapy vectors more versatile

Time-reversal acoustics research promises medical breakthroughs

Completion of the sequencing of human chromosome 19

New method to induce embryonic stem cells to develop into bone marrow and blood cells

A new technique for engineering protein crystals is helping scientists figure out the three-dimensional structures of some important biological molecules

Scientists studying vaccinia virus, a relative of smallpox, have determined that a gene necessary for virus replication also has a key role in turning off inflammation

Ohio university to get major expansion cancer program

NeoRx Corporation acquires worldwide rights to platinum-based anti-cancer agent

New center enables genetic treatments and advances

Compounds that may stop replication of T-cell leukemia virus

Lab discovers way to keep short-lived catalysts active for longer than five months

Scientists have discovered that a non-genetic molecular process can effect cell behaviour

T-cells in lupus patients avoid apoptosis and are stimulated to produce antibodies against the patients own DNA

How rat's genetic blueprint stacks up against those of mice and humans

SARS virus vaccine stimulates protective immune response

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