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LMU researchers shed light on DNA repair mechanisms in Cockayne syndrome

Cockayne syndrome is a severe autosomal recessive disorder caused by defective DNA repair mechanisms.

10 Apr 2024

Blood protein could be a potential biomarker for delayed concussion recovery in children

Researchers have discovered a blood protein that could help detect which children will experience ongoing concussion symptoms more than two weeks after an injury.

9 Apr 2024

Electroconvulsive Therapy found to be safe and effective treatment for some mental illnesses

Researchers have found that Electroconvulsive Therapy (ECT), where an electric current is passed through the brain, can reduce the severity of mental illnesses.

9 Apr 2024

Chronic low-level inflammation may be a contributor to both depression and heart disease

Coronary artery disease and major depression may be genetically linked via inflammatory pathways to an increased risk for cardiomyopathy, a degenerative heart muscle disease, researchers at Vanderbilt University Medical Center and Massachusetts General Hospital have found.

8 Apr 2024

Preventive PCI reduces cardiac event risks in patients with high-risk plaque

People with a buildup of fatty atherosclerotic plaque in the heart's arteries considered at risk of rupturing were far less likely to suffer a serious cardiac event if they underwent percutaneous coronary intervention (PCI), a procedure to open blocked arteries, compared with those who took medications alone but did not undergo PCI, according to research presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Ninerafaxstat shows good tolerability and safety in nonobstructive HCM patients

The investigational drug ninerafaxstat showed a good tolerability and safety profile, along with evidence of improvements in symptoms and exercise capacity among people with nonobstructive hypertrophic cardiomyopathy (HCM), according to results of a 12-week phase 2 trial presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Treating early-stage heart failure in diabetic patients: Insights from ARISE-HF trial

One of the first studies to attempt to treat early-stage heart failure in patients with Type 2 diabetes did not meet its primary endpoint, but a preplanned subgroup analysis found a statistically significant effect of treatment in patients who were not taking SGLT2 inhibitors or GLP-1 RAs, which are antidiabetic medications that also have benefits for the heart.

8 Apr 2024

ACE inhibitors show no benefit in reducing chemotherapy-induced heart damage

Patients who took an angiotensin-converting enzyme (ACE) inhibitor while undergoing cancer treatment with high-dose anthracycline chemotherapy did not show any difference in troponin T levels, a biomarker associated with heart damage, at one month after their last chemotherapy dose compared with those who did not take an ACE inhibitor, according to a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Impella CP pump shows survival benefit in cardiogenic shock

Implantation of the Impella CP micro-axial flow pump in the hours after a heart attack significantly increased the rate of survival at six months among people suffering cardiogenic shock, according to a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Study: Empagliflozin shows mixed results in heart attack patients

Use of the sodium glucose cotransporter-2 (SGLT-2) inhibitor empagliflozin following a heart attack did not show a significant benefit in reducing overall heart failure hospitalizations or death from any cause, according to a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Interatrial shunt may offer differential benefits based on heart failure type

Patients with heart failure who had a small shunt inserted between the heart's left and right atria did not see any significant benefits overall compared with those who received a placebo procedure after a median of 22 months follow-up, in a study presented at the American College of Cardiology's Annual Scientific Session.

8 Apr 2024

Study questions routine use of beta blockers after heart attack

Taking beta blockers after a heart attack did not significantly reduce the risk of death or a second heart attack among people with normal heart pumping ability, as indicated by an ejection fraction of 50% or higher, according to a study presented at the American College of Cardiology's Annual Scientific Session.

7 Apr 2024

Simple urine test halves cystoscopy procedures for bladder cancer patients

A simple urine test can more than halve the number of cystoscopies necessary to follow up high-risk bladder cancer patients, new research has found.

5 Apr 2024

Tight interconnection in functional capacity indicates reduced resilience in the elderly

In old age, a tighter interlinkage between different domains of functional capacity may indicate a loss of system resilience.

5 Apr 2024

Adeno-associated virus: The gene therapy revolution faces manufacturing and safety hurdles

Recombinant adeno-associated virus (rAAV)-based genetic applications to treat human diseases.

5 Apr 2024

Asthma attacks cause airway damage beyond inflammation, research shows

In asthma, the tightening of muscles around the bronchi causes damage to the airway by squeezing and destroying epithelial cells, which promotes the airway inflammation and mucus production often associated with an asthma attack, researchers report.

4 Apr 2024

Blood-based DNA test spares bladder cancer patients from unnecessary treatments

Testing for tumor DNA in the blood can successfully identify advanced bladder cancer patients who will not relapse following surgery, new research shows.

4 Apr 2024

BMI influences efficacy of nerve-stimulation treatment for sleep apnea, study finds

A nerve-stimulation treatment for obstructive sleep apnea that originally was approved only for people with body mass indexes (BMIs) in the healthy range recently was extended to patients with BMIs up to 40, a weight range generally described as severely obese.

4 Apr 2024

Anti-inflammatory therapy shows promise to treat patients following acute myocardial infarction

Research into the protective effects of two anti-inflammatory molecules, transforming growth factor-beta1 (TGFβ1) and Heligmosomoides polygyrus TGM (HpTGM), following heart attack found that both proteins reduced the inflammatory response within the injured heart and reduced mature scarring.

4 Apr 2024

The horrors of TMJ: Chronic pain, metal jaws, and futile treatments

A TMJ patient in Maine had six surgeries to replace part or all of the joints of her jaw.

4 Apr 2024

Muscle News and Research

LMU researchers shed light on DNA repair mechanisms in Cockayne syndrome

Blood protein could be a potential biomarker for delayed concussion recovery in children

Electroconvulsive Therapy found to be safe and effective treatment for some mental illnesses

Chronic low-level inflammation may be a contributor to both depression and heart disease

Preventive PCI reduces cardiac event risks in patients with high-risk plaque

Ninerafaxstat shows good tolerability and safety in nonobstructive HCM patients

Treating early-stage heart failure in diabetic patients: Insights from ARISE-HF trial

ACE inhibitors show no benefit in reducing chemotherapy-induced heart damage

Impella CP pump shows survival benefit in cardiogenic shock

Study: Empagliflozin shows mixed results in heart attack patients

Interatrial shunt may offer differential benefits based on heart failure type

Study questions routine use of beta blockers after heart attack

Simple urine test halves cystoscopy procedures for bladder cancer patients

Tight interconnection in functional capacity indicates reduced resilience in the elderly

Adeno-associated virus: The gene therapy revolution faces manufacturing and safety hurdles

Asthma attacks cause airway damage beyond inflammation, research shows

Blood-based DNA test spares bladder cancer patients from unnecessary treatments

BMI influences efficacy of nerve-stimulation treatment for sleep apnea, study finds

Anti-inflammatory therapy shows promise to treat patients following acute myocardial infarction

The horrors of TMJ: Chronic pain, metal jaws, and futile treatments

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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