Gene News and Research

Latest Gene News and Research

Research reveals potential target for enfortumab vedotin therapy in urothelial carcinoma

Under the leadership of PD Dr. Niklas Klümper, Assistant Physician at the Department of Urology at the University Hospital Bonn (UKB) and Clinician Scientist of the BMBF-funded ACCENT program and PD Dr. Markus Eckstein, senior physician at the Institute of Pathology at the Uniklinikum Erlangen of the Friedrich-Alexander-University Erlangen-Nürnberg (FAU), an interdisciplinary research team has published new findings that indicate which patients with advanced urothelial carcinoma could benefit in particular from the new targeted therapy with the antibody-drug conjugate enfortumab vedotin.

24 Apr 2024

CASGEVY gene therapy eliminates vaso-occlusive crises in sickle cell patients

In a landmark study, an international consortium led by researchers at Children's Hospital of Philadelphia (CHOP) published the final results of a key clinical trial of the gene therapy CASGEVY (exagamglogene autotemcel) for the treatment of sickle cell disease in patients 12 years and older with recurrent vaso-occlusive crises (VOCs).

24 Apr 2024

Novel lab-grown mini-colons can accurately mimic the development of colorectal tumors

In a breakthrough for cancer research, scientists at EPFL have created lab-grown mini-colons that can accurately mimic the development of colorectal tumors, offering a powerful new tool for studying and testing treatments for the disease.

24 Apr 2024

NYU Langone surgeons perform first combined mechanical heart pump and gene-edited pig kidney transplant surgery

Surgeons at NYU Langone Health performed the first combined mechanical heart pump and gene-edited pig kidney transplant surgery.

24 Apr 2024

Paclitaxel treatment found to directly promote HBV replication and transcription

Hepatitis B virus (HBV) reactivation is commonly observed in individuals with chronic HBV infection undergoing antineoplastic drug therapy.

24 Apr 2024

Timelapse breakthrough: Scientists capture secrets of early embryonic cell division

The beginning of life is shrouded in mystery. While the intricate dynamics of mitosis is well-studied in the so-called somatic cells – the cells that have a specialized function, like skin and muscle cells – they remain elusive in the first cells of our bodies, the embryonic cells.

24 Apr 2024

Novel immunotherapy shows promise for high-risk sarcomas: HEROS 2.0 trial results published

Researchers at Texas Children’s Cancer Center and the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children’s Hospital and Houston Methodist published results of a phase I clinical trial of a novel immunotherapy for high-risk sarcomas in the journal Nature Cancer.

24 Apr 2024

Study unveils novel bladder cancer diagnostic model based on key mitochondrial genes

A novel diagnostic model using machine learning (ML).

24 Apr 2024

New tARC-seq method enhances precision in tracking SARS-CoV-2 mutations

A tARC-seq approach to precisely determine SARS-CoV-2 mutation frequency.

24 Apr 2024

State-of-the art imaging reveals how lipid metabolism is changed in Alzheimer's disease

Alzheimer's disease causes significant problems with memory, thinking and behavior and is the most common form of dementia, affecting more than 50 million people around the world each year.

23 Apr 2024

Study identifies molecular pathway in liver cancer development

As a malignant disease of the liver cells, hepatocellular carcinoma (HCC) is one of the main causes of cancer-related deaths.

23 Apr 2024

The relationship between calcium consumption at various times of the day and cardiovascular disease

The quantity of calcium consumed at breakfast and dinner was associated with cardiovascular disease (CVD).

23 Apr 2024

Shared gene module links depression and cardiovascular disease

Depression and cardiovascular disease (CVD) are serious concerns for public health. Approximately 280 million people worldwide have depression, while 620 million people have CVD. It has been known since the 1990s that the two diseases are somehow related.

23 Apr 2024

Cells use liquid droplets to regulate signaling pathways, study finds

Healthy cells respond appropriately to changes in their environment. They do this by sensing what's happening outside and relaying a command to the precise biomolecule in the precise domain that can carry out the necessary response.

22 Apr 2024

Breakthrough study reveals role of histone deacetylases in inflammatory bowel disease

In a scientific breakthrough, Mount Sinai researchers have revealed the biological mechanisms by which a family of proteins known as histone deacetylases (HDACs) activate immune system cells linked to inflammatory bowel disease (IBD) and other inflammatory diseases.

22 Apr 2024

New research identifies risk factors for dilated cardiomyopathy in genetic carriers

Dilated cardiomyopathy is the most frequent cause of heart failure in young people and is the leading cause of heart transplantation. In this disease, the heart enlarges and reduces its capacity to pump blood. People with dilated cardiomyopathy are at high risk for arrhythmias and sudden death.

22 Apr 2024

Exploring serine and glycine metabolism in hepatocellular carcinoma

Targeted therapy and immunotherapy have emerged as treatment options for hepatocellular carcinoma (HCC) in recent years. The significance of serine and glycine metabolism in various cancers is widely acknowledged.

22 Apr 2024

Do neighborhood-level disparities in breast cancer–specific survival remain after accounting for individual, tumor, and treatment characteristics?

The role of neighborhood-level disparities in determining shorter breast cancer-specific survival.

22 Apr 2024

Top pharmaceutical company evaluates Optimer for precision liver medicine

Optimer delivery vehicle has been shipped to a pharma partner for external evaluation.

From Aptamer Group 22 Apr 2024

Study links air pollution to increased colorectal cancer risk through DNA changes

Researchers reveal how air pollution increases colorectal cancer (CRC) risk through epigenetic changes, using a large-scale study and Mendelian randomization to demonstrate ambient pollution’s impact on CRC mortality and incidence in China.

21 Apr 2024

Gene News and Research

Latest Gene News and Research

Research reveals potential target for enfortumab vedotin therapy in urothelial carcinoma

CASGEVY gene therapy eliminates vaso-occlusive crises in sickle cell patients

Novel lab-grown mini-colons can accurately mimic the development of colorectal tumors

NYU Langone surgeons perform first combined mechanical heart pump and gene-edited pig kidney transplant surgery

Paclitaxel treatment found to directly promote HBV replication and transcription

Timelapse breakthrough: Scientists capture secrets of early embryonic cell division

Novel immunotherapy shows promise for high-risk sarcomas: HEROS 2.0 trial results published

Study unveils novel bladder cancer diagnostic model based on key mitochondrial genes

New tARC-seq method enhances precision in tracking SARS-CoV-2 mutations

State-of-the art imaging reveals how lipid metabolism is changed in Alzheimer's disease

Study identifies molecular pathway in liver cancer development

The relationship between calcium consumption at various times of the day and cardiovascular disease

Shared gene module links depression and cardiovascular disease

Cells use liquid droplets to regulate signaling pathways, study finds

Breakthrough study reveals role of histone deacetylases in inflammatory bowel disease

New research identifies risk factors for dilated cardiomyopathy in genetic carriers

Exploring serine and glycine metabolism in hepatocellular carcinoma

Do neighborhood-level disparities in breast cancer–specific survival remain after accounting for individual, tumor, and treatment characteristics?

Top pharmaceutical company evaluates Optimer for precision liver medicine

Study links air pollution to increased colorectal cancer risk through DNA changes

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut