Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

VUMC researchers discover potent antibody against influenza B

Researchers at Vanderbilt University Medical Center have isolated human monoclonal antibodies against influenza B, a significant public health threat that disproportionately affects children, the elderly and other immunocompromised individuals.

31 May 2024

Single infusion of engineered T-cells achieves lasting asthma remission in mice

Researchers demostrate that durable asthma remission can be achieved with engineered and long-lived CAR T-cell treatment in mice.

31 May 2024

Foam-based delivery system could revolutionize gene therapies

Foam mixed with medications is already used to treat conditions such as varicose veins, hemorrhoids, wounds on the skin and even hair loss.

29 May 2024

Understanding genetic mosaicism in human cells

In a study led by Jan Korbel at the European Molecular Biology Laboratory (EMBL) and Ashley Sanders at the Berlin Institute for Medical Systems Biology of the Max Delbrück Center (MDC-BIMSB), researchers have found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations – copy number variations and chromosomal rearrangements, for example – without causing any apparent disease or abnormality.

28 May 2024

Heart failure triggers multimorbidity by altering stem cells, study reveals

Researchers identified that heart failure (HF) promotes multimorbidity by altering hematopoietic stem cells (HSCs) to produce pro-inflammatory macrophages, increasing vulnerability in multiple organs. The study highlights the role of suppressed TGF-β signaling in these alterations, contributing to chronic inflammation and subsequent health issues.

28 May 2024

New antibody therapy shows promise in combating kidney transplant rejection

Antibody-mediated rejection (AMR) is one of the most common causes of kidney transplant failure. To date, however, no treatment has proven effective in combating this complication in the long term.

27 May 2024

Evolving treatment paradigms in multiple myeloma could improve patient outcomes

The treatment landscape for multiple myeloma, the second most common blood cancer, is shifting rapidly, with newly diagnosed patients increasingly being treated with a four-part drug combination that includes a new immunotherapy agent.

24 May 2024

New stem cell transplant approach may expand donor pool for high-risk blood cancer patients

A new treatment approach using an older drug may enable more patients with high-risk blood cancers to receive transplanted stem cells from unrelated, partially matched donors, according to a study conducted by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and colleagues.

23 May 2024

Research aims to better understand the origin of eosinophils

Eosinophils are specialized cells of our immune system. They are identified by their distinctive granules that stain red when treated with an acidic reagent, eosin, which gave them their name.

22 May 2024

Inherited iron defects uncovered in endemic Indian population

Although iron deficiency anemia is the most prevalent form of anemia globally, it may be underdiagnosed due to lack of awareness or methodical screening.

20 May 2024

Metformin use linked to reduced risk of myeloproliferative neoplasms

People who use metformin are less likely to develop a myeloproliferative neoplasm (MPN) over time, indicating that the treatment may help prevent the development of certain types of cancers, according to a study published in Blood Advances.

17 May 2024

Rapid Novor teams up with PMCC to evaluate EasyM™ for multiple myeloma minimal residual disease monitoring

Rapid Novor Inc., a global leader in mass spectrometry (MS)-based antibody protein sequencing, today announced that the first patient has been enrolled in a new clinical study titled 'Clinical evaluation of EasyM™ for disease response analysis in newly diagnosed MM patients (NDMM)'.

From Rapid Novor Inc 16 May 2024

Experimental gene therapy shows promise for treating herpes infections

Researchers at Fred Hutch Cancer Center have found in pre-clinical studies that an experimental gene therapy for genital and oral herpes removed 90% or more of the infection and suppressed how much virus can be released from an infected individual, which suggests that the therapy would also reduce the spread of the virus.

13 May 2024

AML patients at the extremes of older age derive benefit from VEN-HMA regimen

Standard of care treatment for acute myeloid leukemia (AML) is safe and effective for adults over 80, according to a study published in Blood Neoplasia. For roughly a quarter of patients, this treatment can durably prolong survival.

9 May 2024

Anger damages blood vessel function, raising heart disease risk

A recent study in the Journal of the American Heart Association reveals that provoked anger, but not sadness or anxiety, acutely impairs endothelial function, shedding light on the link between anger and cardiovascular events.

2 May 2024

Investigating fertilized ACL surgery's impact on return to play in athletes

The Marshall University Joan C. Edwards School of Medicine is now accepting applicants for an observational trial focused on fertilized anterior cruciate ligament (ACL) reconstruction.

2 May 2024

Unlocking the secrets of long-lived hematopoietic stem cells

Nothing lives forever, but compared to other cells in the body, hematopoietic stem cells (HSCs) are remarkably long-lived. HSCs are blood-forming cells – they give rise to rapidly dividing progenitor cells, which in turn generate hundreds of billions of cells to fulfill the daily demand of oxygen-delivering red blood cells, disease-fighting white blood cells and clot-forming platelets.

30 Apr 2024

Research sheds light on post-sepsis immune suppression mechanism

Severe sepsis from bacterial or viral infections can be life-threatening and even people recovering from severe sepsis may experience long-lasting effects on the immune system, making them more susceptible to recurrent infections.

13 Apr 2024

Heart transplant recipient's journey: From patient to advocate

Glen Kelley's journey as a heart transplant recipient came full circle today in Prague, as he addressed attendees of the Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), including members of his own care teams.

12 Apr 2024

Innovative cancer treatment approach yields promising results in pediatric patients

Researchers have developed a functional precision medicine approach that targets cancer by combining genetic testing with a new way to test individual drugs on tumor samples.

12 Apr 2024