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Obicetrapib slashes LDL cholesterol by over 30% in high-risk heart patients

A large multinational trial published in the New England Journal of Medicine shows that obicetrapib significantly lowers LDL cholesterol in high-risk cardiovascular patients. The CETP inhibitor also improved key lipid parameters with no major safety concerns, supporting its role in future combination therapies.

8 May 2025

Next-generation "armored" CAR T cell therapy shows promising results in lymphoma patients

A next-generation "armored" CAR T cell therapy showed promising results in a small study of patients whose B-cell lymphomas continued to resist multiple rounds of other cancer treatments, including commercially available CAR T cell therapies.

8 May 2025

Anti-parasitic drug could accelerate the elimination of infection endemic to Africa

Tens of millions of people in Africa are infected by parasitic worms that cause lymphatic filariasis (also called elephantiasis), a disease that leads to severe swelling and deformities of the limbs and genitals.

7 May 2025

Low-dose rapamycin shows promise for enhancing healthspan in older adults

A new research paper was published in Aging (Aging-US) Volume 17, Issue 4, on April 4, 2025, titled "Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results."

7 May 2025

Immunotherapy before and after surgery boost longer event-free survival in head and neck cancer

Patients with locally advanced head and neck cancer who received the immune checkpoint inhibitor pembrolizumab before, during and after standard-of-care surgery had longer event-free survival without the cancer coming back and higher rates of substantial tumor shrinkage prior to surgery, according to the first interim analysis of a randomized, open-label phase 3 clinical trial led by investigators from Dana-Farber Brigham Cancer Center and Washington University School of Medicine in St. Louis.

6 May 2025

Clinical trial underway to assess effectiveness and safety of potential Long Covid treatment

A clinical trial is underway to assess the effectiveness and safety of sipavibart, AstraZeneca's long-acting monoclonal antibody designed to provide protection against Covid-19, as a potential treatment for Long Covid, the Nova Southeastern University (NSU) and the Schmidt Initiative for Long Covid (SILC) announced today.

1 May 2025

Brensocatib once-daily pill shows benefits for chronic lung disease

Results of a large, global clinical trial spanning five continents with over 1,700 patients with bronchiectasis, published this April in the New England Journal of Medicine, demonstrated benefits of an investigational, once-a-day pill called brensocatib as a therapy for the chronic lung condition.

30 Apr 2025

Semaglutide shows promise in treating severe liver disease

Semaglutide effectively treats liver disease in two thirds of patients, new research has found.

30 Apr 2025

HonorHealth Research Institute treats first patient in global trial targeting aggressive melanoma

HonorHealth Research Institute recently treated the first patient in a 50-site international clinical trial that will test a new type of therapy aimed at difficult-to-treat melanoma, an aggressive type of skin cancer.

29 Apr 2025

New CAR T cell therapy shows promise for treating advanced thyroid cancer

A new chimeric antigen receptor (CAR) T cell therapy called AIC100, which targets the ICAM-1 protein, demonstrated encouraging responses and an acceptable safety profile in patients with two types of advanced thyroid cancer, according to researchers from The University of Texas MD Anderson Cancer Center.

29 Apr 2025

$Innovative CAR-T cell therapy achieves remarkable results in patients with refractory CD30+ lymphoma$

Innovative CAR-T cell therapy achieves remarkable results in patients with refractory CD30+ lymphoma

Researchers from the Sant Pau Research Institute (IR Sant Pau), in collaboration with Sant Pau Hospital and the Josep Carreras Leukaemia Research Institute, have developed an innovative CAR-T cell therapy targeting the CD30 protein (HSP-CAR30), which has shown high efficacy in patients with refractory CD30+ lymphoma.

29 Apr 2025

Immunotherapy replaces surgery for early-stage dMMR cancers in landmark study

Neoadjuvant PD-1 blockade with dostarlimab achieved high rates of organ preservation in patients with early-stage mismatch repair-deficient (dMMR) solid tumors across multiple types. Most patients avoided surgery with durable disease control, reshaping potential cancer treatment pathways.

28 Apr 2025

UQ begins first human trial of immunotherapy for Type 1 diabetes

Researchers at The University of Queensland have dosed 5 participants in the first clinical trial of a potentially revolutionary immunotherapy drug to treat Type 1 diabetes.

28 Apr 2025

Targeted drug zongertinib shows strong results for HER2-mutant lung cancer in clinical trial

The HER2-targeted therapy zongertinib demonstrated clinical benefits for previously treated patients with advanced HER2-mutant non-small cell lung cancer – particularly those with specific HER2 mutations – with manageable side effects, according to results from the Phase Ia/Ib Beamion LUNG-1 trial led by researchers from The University of Texas MD Anderson Cancer Center.

28 Apr 2025

New topical gel reduces painful rash from colorectal cancer treatment

Researchers from the UCLA Health Jonsson Comprehensive Cancer Center and The University of Texas MD Anderson Cancer Center have demonstrated that a novel topical BRAF inhibitor gel called LUT014 significantly reduces the severity of an acne-like rash, a common and painful side effect experienced by patients undergoing anti-EGFR therapies for colorectal cancer.

28 Apr 2025

Pre and post-surgical immunotherapy improves survival in head and neck cancer patients

27 Apr 2025

MD Anderson researchers present promising clinical trial results at AACR 2025

Researchers from The University of Texas MD Anderson Cancer Center will present promising results from clinical trials in three minisymposia abstracts at the American Association for Cancer Research (AACR) Annual Meeting 2025.

26 Apr 2025

Common diabetes drug can reduce the pain of people with knee osteoarthritis and obesity

A common diabetes drug can reduce the pain of people with knee osteoarthritis and overweight or obesity, possibly delaying the need for knee replacements, Monash University-led research has found.

24 Apr 2025

Monoclonal antibody can effectively reverse bleeding complications linked to ticagrelor

An investigational monoclonal antibody called bentracimab can safely and effectively reverse potentially catastrophic bleeding complications linked to ticagrelor, a common drug used to treat patients with acute coronary syndromes, prior heart attack, stroke, and coronary artery disease.

24 Apr 2025

Global clinical trial tests two anti-inflammatory drugs for long COVID

Spanning four continents and enrolling hundreds of people, a new clinical trial will test the effectiveness of two anti-inflammatory medicines as potential treatments for long COVID, scientists from Western University and the Schmidt Initiative for Long Covid (SILC) announced today.

24 Apr 2025

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Drug Trial News

Obicetrapib slashes LDL cholesterol by over 30% in high-risk heart patients

Next-generation "armored" CAR T cell therapy shows promising results in lymphoma patients

Anti-parasitic drug could accelerate the elimination of infection endemic to Africa

Low-dose rapamycin shows promise for enhancing healthspan in older adults

Immunotherapy before and after surgery boost longer event-free survival in head and neck cancer

Clinical trial underway to assess effectiveness and safety of potential Long Covid treatment

Brensocatib once-daily pill shows benefits for chronic lung disease

Semaglutide shows promise in treating severe liver disease

HonorHealth Research Institute treats first patient in global trial targeting aggressive melanoma

New CAR T cell therapy shows promise for treating advanced thyroid cancer

Innovative CAR-T cell therapy achieves remarkable results in patients with refractory CD30+ lymphoma

Immunotherapy replaces surgery for early-stage dMMR cancers in landmark study

UQ begins first human trial of immunotherapy for Type 1 diabetes

Targeted drug zongertinib shows strong results for HER2-mutant lung cancer in clinical trial

New topical gel reduces painful rash from colorectal cancer treatment

Pre and post-surgical immunotherapy improves survival in head and neck cancer patients

MD Anderson researchers present promising clinical trial results at AACR 2025

Common diabetes drug can reduce the pain of people with knee osteoarthritis and obesity

Monoclonal antibody can effectively reverse bleeding complications linked to ticagrelor

Global clinical trial tests two anti-inflammatory drugs for long COVID

How microRNA is transforming science: From discovery to diagnostics

Advancing benzodiazepine detection

The Surgeon-Scientist Pioneering Regenerative Engineering

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