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Trial finds no cardiovascular benefit and higher safety risks with spironolactone in dialysis patients

A large international study has found that spironolactone, a medication for high blood pressure and heart failure, does not reduce the risk of heart-related death or hospitalizations in people with kidney failure receiving dialysis, despite earlier smaller studies suggesting benefit.

17 Aug 2025

Engineered CD40 antibody shrinks tumors and induces remission

Over the past 20 years, a class of cancer drugs called CD40 agonist antibodies have shown great promise-and induced great disappointment.

14 Aug 2025

Arginine dentifrices reduce dental caries in children with active caries

The International Association for Dental, Oral, and Craniofacial Research (IADR) and the American Association for Dental, Oral, and Craniofacial Research (AADOCR) have announced the publication of a new study in JDR Clinical & Translational Research that demonstrates that arginine dentifrices reduce dental caries in children with active caries as much as, or more than, a sodium fluoride dentifrice, depending on the arginine concentration.

13 Aug 2025

Early use of risdiplam in newborns with SMA shows improvements in motor development

Spinal muscular atrophy (SMA) is a rare genetic condition that causes progressive muscle weakness, which, when untreated, prevents infants with the most severe form from gaining motor development - never gaining the ability to sit - and typically leads to death before 2 years of age.

13 Aug 2025

Griffith University launches groundbreaking treatment trial for spinal cord injury

A Phase 1 human clinical trial to treat chronic spinal cord injury, the first of its kind in the world, has commenced to test the efficacy and safety of a revolutionary new treatment using nasal cells.

13 Aug 2025

New drug-releasing system eliminates tumors in 82% of high-risk bladder cancer patients

A new drug-releasing system, TAR-200, eliminated tumors in 82% of patients in a phase 2 clinical trial for individuals with high-risk non-muscle-invasive bladder cancer whose cancer had previously resisted treatment.

13 Aug 2025

SNMMI launches AI-powered platform to connect patients with radiopharmaceutical trials

The Society of Nuclear Medicine and Molecular Imaging (SNMMI) is proud to announce the launch of the Global Radiopharmaceutical Trial Finder a revolutionary, AI-powered platform designed to help researchers, clinicians and patients instantly discover radiopharmaceutical clinical trials that meet their specific needs.

12 Aug 2025

Early clinical trial supports MASL as a targeted oral cancer treatment

Rowan University and Sentrimed, a clinical-stage biopharmaceutical company focused on developing safer, orally dosed oncology therapies, today announced results from a National Cancer Institute (NCI) funded clinical trial evaluating MASL in patients with oral squamous cell carcinoma (OSCC).

8 Aug 2025

Two-drug combo shows durable benefit in advanced kidney cancer

A two-drug combination for treating advanced kidney cancer had sustained and durable clinical benefit in more than five years of follow-up, according to a study published Aug. 1 in Nature Medicine.

1 Aug 2025

Experimental drug found to be safe and effective in treating children with MIS-C

In a small trial, Mass General Brigham researchers found a drug designed to treat Celiac disease supported a more rapid return to normal activities for patients following COVID.

30 Jul 2025

Study finds benefits of personalized ventilation in ICU care

A seven-year international, multi-centre clinical trial led by London Health Sciences Centre Research Institute (LHSCRI) and St. Michael's Hospital, a site of Unity Health Toronto, has found that a new ventilation mode called proportional assist ventilation (PAV+™) could improve outcomes for patients in the intensive care unit (ICU) who require help breathing.

24 Jul 2025

Low-dose olanzapine reduces chemo-induced nausea with fewer side effects

Chemotherapy-induced nausea and vomiting are among the most distressing side effects of anti-cancer treatment, particularly for those receiving highly emetogenic regimens such as anthracycline plus cyclophosphamide combinations.

24 Jul 2025

Innovative immunotherapy trial opens for newly-diagnosed glioblastoma patients

A UCL-sponsored clinical trial for patients newly diagnosed with glioblastoma, an aggressive form of brain cancer, has opened at UCLH's National Hospital for Neurology and Neurosurgery and Clinical Research Facility, in memory of Baroness Margaret McDonagh.

24 Jul 2025

Chinese study shows lasting weight loss after tirzepatide treatment

Obesity has become a global epidemic, contributing to a host of chronic health conditions such as type 2 diabetes, hypertension, and cardiovascular disease.

23 Jul 2025

STRIDE immunotherapy sets new benchmark for survival in advanced liver cancer

A new exploratory analysis of the HIMALAYA phase III trial involving patients with unresectable hepatocellular carcinoma (uHCC, an advanced liver cancer that could not be treated with surgery or other localized treatments) has shown that one in five (19.6%) participants treated with STRIDE (Single Tremelimumab Regular Interval Durvalumab) a combination of two immunotherapies, remained alive after five years of follow-up versus one in 10 (9.4%) participants treated with sorafenib, a standard treatment for uHCC when the study was designed.

23 Jul 2025

New antibody therapy offers hope for fragile patients with Fanconi anemia

An antibody treatment developed at Stanford Medicine successfully prepared patients for stem cell transplants without toxic busulfan chemotherapy or radiation, a phase 1 clinical trial has shown.

22 Jul 2025

AI-guided patient stratification boosts Alzheimer’s trial outcomes and efficiency

Scientists have used an AI model to reassess the results of a completed clinical trial for an Alzheimer's disease drug.

17 Jul 2025

UNM researchers get $1 million grant to launch early clinical trial for Alzheimer’s vaccine

University of New Mexico researchers have received funding to launch an early-stage clinical trial of a vaccine engineered to clear pathological tau protein from the brains of patients suffering from Alzheimer's dementia.

15 Jul 2025

Long-term survival achieved in stage III melanoma with pre-surgery immunotherapy

Four years after pre-surgery treatment with a novel combination of immune checkpoint inhibitors, nivolumab and relatlimab, 87% of patients with stage III melanoma remained alive, according to new results from a study led by researchers at The University of Texas MD Anderson Cancer Center.

12 Jul 2025

Teclistamab shows promising results in heavily pretreated multiple myeloma

Teclistamab-cqyv (Tecvayli) led to clinically meaningful responses in patients with heavily pretreated multiple myeloma who would have been ineligible for the MajesTEC-1 trial, and identified a novel factor independently associated with outcomes.

12 Jul 2025

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Drug Trial News

Trial finds no cardiovascular benefit and higher safety risks with spironolactone in dialysis patients

Engineered CD40 antibody shrinks tumors and induces remission

Arginine dentifrices reduce dental caries in children with active caries

Early use of risdiplam in newborns with SMA shows improvements in motor development

Griffith University launches groundbreaking treatment trial for spinal cord injury

New drug-releasing system eliminates tumors in 82% of high-risk bladder cancer patients

SNMMI launches AI-powered platform to connect patients with radiopharmaceutical trials

Early clinical trial supports MASL as a targeted oral cancer treatment

Two-drug combo shows durable benefit in advanced kidney cancer

Experimental drug found to be safe and effective in treating children with MIS-C

Study finds benefits of personalized ventilation in ICU care

Low-dose olanzapine reduces chemo-induced nausea with fewer side effects

Innovative immunotherapy trial opens for newly-diagnosed glioblastoma patients

Chinese study shows lasting weight loss after tirzepatide treatment

STRIDE immunotherapy sets new benchmark for survival in advanced liver cancer

New antibody therapy offers hope for fragile patients with Fanconi anemia

AI-guided patient stratification boosts Alzheimer’s trial outcomes and efficiency

UNM researchers get $1 million grant to launch early clinical trial for Alzheimer’s vaccine

Long-term survival achieved in stage III melanoma with pre-surgery immunotherapy

Teclistamab shows promising results in heavily pretreated multiple myeloma

Todd Bauman and Chris Povich

Scaling organ‑chip technology for human‑relevant drug discovery

Unlocking drug amorphization: Continuous, solvent-free twin screw granulation

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