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Integrated NGS system can deliver accurate, genomics-based diagnoses to accelerate treatment for myeloid neoplasms

Identifying recurrent genetic alterations in myeloid neoplasms has improved diagnosis and expanded targeted treatments available to patients. However, treatment initiation can be delayed by the variable and lengthy turnaround times involved in testing for these alterations.

7 Feb 2023

Researchers identify a new genetic risk factor for age-related macular degeneration

Researchers at Tel Aviv University identified a new genetic risk factor for the complex eye disease AMD (Age-related Macular Degeneration), a leading cause for loss of eyesight at an advanced age.

6 Feb 2023

Microbial polyphenols in Mediterranean diet improve cardiovascular health

Researchers observe a robust association between urinary phenolic metabolites, Mediterranean diet adherence, and a healthier cardiovascular status.

29 Jan 2023

Atomic-level computer model of the H1N1 virus reveals new vulnerabilities

According to the World Health Organization, each year there are an estimated 1 billion cases of influenza, between 3-5 million severe cases and up to 650,000 influenza-related respiratory deaths globally.

25 Jan 2023

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome -; a cell's complete set of DNA -; is most vulnerable while it is being duplicated before a cell divides. Cancer cells constantly are dividing, so their genomes are constantly in jeopardy.

24 Jan 2023

Combination of multiple maps uncovers new genetic risk factor for AMD

Combining a map of gene regulatory sites with disease-associated loci has uncovered a new genetic risk factor of adult-onset macular degeneration (AMD), according to a new study publishing January 17th in the open access journal PLOS Biology by Ran Elkon and Ruth Ashery-Padan of Tel Aviv University, Israel, and colleagues.

18 Jan 2023

Researchers develop an artificial neuron closely mimicking the characteristics of a biological neuron

Researchers reported a conductance-based organic electrochemical neuron that mimicked biological signaling in neurons, especially activation/inactivation of their sodium and potassium channels.

16 Jan 2023

Recent progress in the understanding of neuraminidase-specific antibodies for the development of universal influenza vaccines

A recent study published in Viruses reviewed the characteristics of neuraminidase with emphasis on the development of NA-based universal influenza vaccines.

12 Jan 2023

Targeting Piezo2 could provide new avenue for treating chronic pain related to gastrointestinal disorders

Targeting a receptor responsible for our sense of touch and temperature, which researchers have now found to be present in our colon, could provide a new avenue for treating chronic pain associated with gastrointestinal disorders such as irritable bowel syndrome.

23 Dec 2022

Newly discovered mechanism could explain memory impairment in epilepsy

People with chronic epilepsy often experience impaired memory. Researchers at the University of Bonn have now found a mechanism in mice that could explain these deficits.

19 Dec 2022

New method uses light to change long-term behavior of neurons

Researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and MIT have developed a new method to target diseased neurons in the brain and change their long-term behavior using light, paving the way for potential new treatments for neurological conditions such as epilepsy and autism.

8 Dec 2022

UKSRC researchers work with community partners to protect Kentuckians from 'forever chemicals'

Nearly every person in the United States has been exposed to per- and polyfluorinated alky substances (PFAS) at some point in their life.

7 Dec 2022

Study shows how ketamine administration starkly changes neuronal activity patterns in the brain

Ketamine, an established anesthetic and increasingly popular antidepressant, dramatically reorganizes activity in the brain, as if a switch had been flipped on its active circuits, according to a new study by Penn Medicine researchers.

1 Dec 2022

Metrion Biosciences invests in new High Throughput Screening capability and expanded facilities

Metrion Biosciences Limited (“Metrion”), the specialist ion channel contract research and drug discovery company, today announced the launch of its High Throughput Screening (HTS) capability, as well as the expansion of its state-of-the-art lab and office facilities. Scott Maidment has been appointed as Head of HTS to lead the new service.

From Metrion Biosciences Limited 1 Dec 2022

Specific genetic variant linked to early-onset childhood epilepsy discovered

Researchers at Children's Hospital of Philadelphia (CHOP) have discovered a specific genetic variant in SCN1A, the most common genetic epilepsy, that leads to an earlier onset of epilepsy, with clinical features distinct from other epilepsies.

30 Nov 2022

Bioorthogonal system for targeted release of nitrite ions into cancer cells

A team of researchers writing in the journal Angewandte Chemie has developed a bioorthogonal molecular system for the targeted introduction of nitrite ions into cells.

30 Nov 2022

The biological properties of the SARS-CoV-2 E protein in the context of HIV-1

Researchers assessed the effectiveness of SARS-CoV and SARS-CoV-2 envelope proteins against HIV-1.

22 Nov 2022

Are fungal mycelium skin-derived MycelioTronics an environmentally friendly substitute for electronics?

Researchers proposed a novel approach to develop flexible and biodegradable electronics called MycelioTronics, which could substitute for electronic substrate material.

15 Nov 2022

Copper and copper-binding proteins could be potential targets for cancer treatment

For cancer cells to grow and spread around the human body, they need proteins that bind copper ions. New research about how cancer-related proteins bind the metal and how they interact with other proteins, opens up potential new drug targets in the fight against cancer.

10 Nov 2022

Study uncovers a previously unknown propofol effect in neurons

Propofol is the most commonly used drug to induce general anesthesia. Despite its frequent clinical application, it is poorly understood how propofol causes anesthesia.

7 Nov 2022