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Study exploits biomolecular condensates to inhibit androgen receptor in prostate cancer

Transcription factors play essential roles in turning the genetic information encoded in genes into proteins in all cells and organisms.

5 Dec 2023

Osteopontin-c: A key player in mitochondrial biogenesis and cancer metastasis

A new research paper was published in Oncotarget's Volume 14 on December 1, 2023, entitled, "Osteopontin induces mitochondrial biogenesis in deadherent cancer cells."

5 Dec 2023

Study reveals how maternal diabetes affects birth defects at the single-cell level

The mechanisms by which maternal diabetes mellitus contributes to congenital abnormalities in the fetus.

4 Dec 2023

Gut microbe Lactobacillus found to bolster stress resilience, new study reveals

Study demonstrates that the gut microbe Lactobacillus helps maintain normal levels of the cytokine interferon-gamma (IFNγ), providing protection against stress-induced disruptions in a mouse model. The findings suggest Lactobacillus's crucial role in building resilience to environmental stressors, highlighting its potential in treating mood disorders.

3 Dec 2023

New study provides convincing evidence of the essential role of cylicins in sperm development and fertility

Researchers investigated the Role of Cylicins in Spermiogenesis and Male Fertility in Mice and Humans through Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/ CRISPR-associated protein 9 (Cas9) Gene Editing.

30 Nov 2023

The effects of vitamin K on bone health

Existing scientific data on the effects of vitamin K (VK) on bone health and elucidated the underlying mechanisms.

30 Nov 2023

Portable AI-driven COVID-19 test detects variants with high accuracy

A new AI-assisted molecular diagnostic platform capable of identifying variants of COVID-19 and other infectious diseases has been developed by scientists in the UK. The low cost, portable device could play a crucial role in preventing future pandemics due to its accuracy and versatility.

29 Nov 2023

Decoding anxiety: Study reveals brain's role in behavioral inhibition risks

Researchers in the U.S. used non-human primate models to explore the molecular mechanisms and neural systems behind behavioral inhibition, a key risk factor for anxiety disorders. The study identified molecular systems in the posterior orbitofrontal cortex linked to variations in anxious temperament, offering potential targets for treating anxiety disorders.

28 Nov 2023

New heart organoid model could revolutionize drug development and toxicology studies

Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists – so far.

28 Nov 2023

Scientists uncover new therapeutic targets for high-risk pediatric leukemia

Scientists at St. Jude Children's Research Hospital comprehensively identified genes directly regulated by a protein associated with high-risk pediatric leukemias.

28 Nov 2023

Potential breakthrough in breast cancer: Five proteins identified as risk markers

Researchers used a Mendelian randomization approach to conduct a genetic association analysis of the levels of over 3,000 proteins to identify biomarkers for early breast cancer detection.

28 Nov 2023

Omega-3s in the spotlight: The impact of EPA and DHA on athlete health and performance

Research paper reviews the effects of omega-3 fatty acids, EPA, and DHA, on athletes, discussing their benefits in inflammation control, cognitive function, and muscle maintenance, and the need for further research to fully understand their impact. It also addresses the risks and optimal intake of these supplements, highlighting their potential to improve athletic performance and recovery with minimal adverse effects at recommended doses.

27 Nov 2023

Genetic vulnerability of leukemia cells uncovered

Leukemia is the most common type of cancer in children. Treatment involves intensive chemotherapy, which has severe side effects due to its non-specific mode of action.

22 Nov 2023

Scientists uncover key to enhancing cancer-killing T cells

T cells are the key immune system component involved in killing cancer. Tumors produce signals that turn off these T cells, partially by forcing them to progressively differentiate (mature) into a hypofunctional state known as exhaustion.

21 Nov 2023

Breakthrough in HIV treatment: NMN shows promise in reducing CD4+ T cell activation

The impact of nicotinamide mononucleotide (NMN) on Clusters of differentiation 4+ (CD4+ ) Thymus cells (T cells) viz.

21 Nov 2023

New study links DNA methylation in GLP1R gene to obesity without metabolic disorders

The study investigates the role of epigenetic changes in GLP1R gene polymorphisms on metabolically healthy obesity (MHO), revealing that apart from genetic variations, DNA methylation significantly influences the occurrence of MHO.

20 Nov 2023

Groundbreaking technology developed to extract mesenchymal stem cells from pure bone marrow

Researchers from the Critical Analytics for Manufacturing Personalized-Medicine (CAMP) Interdisciplinary Research Group (IRG) of Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with the Agency for Science, Technology and Research (A*STAR) Bioprocessing Technology Institute (BTI) and National University Health System (NUHS), have developed a groundbreaking technology capable of extracting mesenchymal stem cells (MSCs) directly from pure bone marrow – also known as bone marrow aspirate (BMA), a pivotal source of MSCs – without dilution.

20 Nov 2023

Avian influenza A H5N1 virus impacts wide range of wildlife in the U.S., study shows

Study highlights the spread of the highly pathogenic avian influenza A (H5N1) virus among non-domesticated animals in the U.S., revealing neurological symptoms as a key clinical presentation and expanding the range of species affected by this Eurasian lineage virus.

19 Nov 2023

TACTIC project aims to uncover genetic causes of cancer and develop targeted therapies

Investigating the genetic causes of cancer and fighting them with new drugs: To this end, German Cancer Aid is funding the TACTIC project until 2028 with 11.8 million euros.

16 Nov 2023

Rare APOE3-R136S mutation offers protection against Alzheimer's disease pathologies in new study

The R136S genetic mutation protected against apolipoprotein E4 (APOE4)-induced late-onset Alzheimer’s disease (LOAD).

16 Nov 2023

Transcription News and Research

Study exploits biomolecular condensates to inhibit androgen receptor in prostate cancer

Osteopontin-c: A key player in mitochondrial biogenesis and cancer metastasis

Study reveals how maternal diabetes affects birth defects at the single-cell level

Gut microbe Lactobacillus found to bolster stress resilience, new study reveals

New study provides convincing evidence of the essential role of cylicins in sperm development and fertility

The effects of vitamin K on bone health

Portable AI-driven COVID-19 test detects variants with high accuracy

Decoding anxiety: Study reveals brain's role in behavioral inhibition risks

New heart organoid model could revolutionize drug development and toxicology studies

Scientists uncover new therapeutic targets for high-risk pediatric leukemia

Potential breakthrough in breast cancer: Five proteins identified as risk markers

Omega-3s in the spotlight: The impact of EPA and DHA on athlete health and performance

Genetic vulnerability of leukemia cells uncovered

Scientists uncover key to enhancing cancer-killing T cells

Breakthrough in HIV treatment: NMN shows promise in reducing CD4+ T cell activation

New study links DNA methylation in GLP1R gene to obesity without metabolic disorders

Groundbreaking technology developed to extract mesenchymal stem cells from pure bone marrow

Avian influenza A H5N1 virus impacts wide range of wildlife in the U.S., study shows

TACTIC project aims to uncover genetic causes of cancer and develop targeted therapies

Rare APOE3-R136S mutation offers protection against Alzheimer's disease pathologies in new study

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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