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Red grape polyphenol, resveratrol: a multifaceted therapeutic powerhouse under review

The therapeutic potential of resveratrol, a red grape polyphenol.

25 Oct 2023

HIF-2α inhibitor belzutifan significantly reduces progression of clear cell renal cell carcinoma

Belzutifan significantly reduced the risk of progression of clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer, in patients previously treated with immune checkpoint inhibitors and anti-angiogenic therapies compared with everolimus in a phase 3 clinical trial.

24 Oct 2023

Lactobacillus iners in tumors: Driving chemoradiation resistance via lactate-induced metabolic rewiring

Investigating tumor and gut microbiome traits that impact chemoradiation therapy in patients with cervical cancer.

24 Oct 2023

Global surge of highly pathogenic avian influenza H5N1

A recent study published in Nature sheds light on the complex dynamics of highly pathogenic avian influenza (HPAI) H5N1 since 2021, uncovering critical shifts in the virus's behavior and providing insights for more effective mitigation strategies. The research emphasizes the importance of understanding the ecological and virological factors driving the intensified global activity of HPAI H5N1 to better prepare for and manage future outbreaks.

22 Oct 2023

Lactate-producing intratumoral bacteria drive resistance to radiation therapy

Researchers at The University of Texas MD Anderson Cancer Center have discovered that lactate-producing intratumoral bacteria drives resistance to radiation therapy, suggesting that lactic acid-producing bacteria present in various cancers may serve as novel therapeutic targets.

19 Oct 2023

Mitochondrial protein CHCHD2 plays important role in glioblastoma progression

Glioblastoma is the most common type of brain tumor that affects adults and, unfortunately, still remains incurable. In a new study, researchers have demonstrated that a specific mitochondrial protein plays an important role in glioblastoma, and can therefore be used as a potential target to reduce tumors.

17 Oct 2023

Research paves the way for new approach to tackling treatment resistance in cancer

Researchers at the University of California San Diego have discovered a process in which liver cells share molecules via vesicle exchange in order to multiply under conditions that would ordinarily suppress cell proliferation.

17 Oct 2023

Impact of ketogenic diets on breast cancer

The therapeutic potential of the ketogenic diet (KD) for breast cancer (BC).

17 Oct 2023

Cracking the code: recent discoveries transform our understanding of cancer-immunity cycle

In a recent review published in Immunity, researchers reviewed tumor-immunity cycle data.

13 Oct 2023

IL-17: The molecule that could revolutionize autoimmune and cancer treatments

The research paper explores the multifaceted role of the IL-17 family in immune response, covering everything from infection control to pathological conditions like autoimmune diseases and cancer. Future therapies may exploit IL-17's unique signaling pathways to offer more targeted and cost-effective treatments.

12 Oct 2023

Macrophages play a central role in intestinal cell renewal, study reveals

A research team from MedUni Vienna and the FWF-sponsored Special Research Area SFB F83 Immunometabolism has now demonstrated for the first time the central role of macrophages in the renewal of intestinal cells, which sheds light on the complex interplay between immune cells and tissue regeneration.

10 Oct 2023

Discovery of a novel therapeutic target for pancreatic cancer

A novel amino acid transporter-based therapeutic target for pancreatic ductal adenocarcinoma (PDAC).

10 Oct 2023

Halting pandemics at the source: The call for a proactive 'One Health' approach

The recent PLoS Pathogens review emphasizes proactively preventing pathogen spillover from animals to humans as a strategy against future pandemics, advocating for a holistic One Health approach that considers the interconnectedness of humans, animals, and the environment. The study underscores the importance of primary prevention, differentiating it from secondary containment, and highlights the economic and societal benefits of preemptive actions over reactive responses.

10 Oct 2023

Study sheds light on PRMT1's role in gastric cancer progression

In a study published in the journal Genes & Diseases, researchers from Southwest University, and Southwest Medical University investigated PRMT1, a protein previously known to be overexpressed in gastric cancer cells.

9 Oct 2023

Midbody remnant found to play role in cancer spread

Once thought to be the trash can of the cell, a little bubble of cellular stuff called the midbody remnant is actually packing working genetic material with the power to change the fate of other cells -; including turning them into cancer.

9 Oct 2023

Blocking TIM-3 checkpoint molecule promotes antitumor immune response in diffuse intrinsic stem glioma

Researchers from Cima and the Clínica Universidad de Navarra, together with the international cooperative group Diffuse Midline Glioma (DMG-ACT), have confirmed that blocking an immune checkpoint molecule reduces the tumor and prolongs survival in animal models of the most aggressive childhood cancer. This research, carried out at the Cancer Center Clínica Universidad de Navarra, shows that inhibition of TIM-3 promotes the immune memory of diffuse intrinsic stem glioma (DIPG) and improves the prognosis of the disease.

9 Oct 2023

Researchers explore immunomodulating targets for improving glioblastoma therapies

Researchers have delved into the intricate heterogeneity of glioblastoma, a notoriously aggressive brain tumor, using advanced single-cell RNA sequencing and innovative zebrafish avatars. Their findings spotlighted the LGALS1 gene's role in immunosuppression and suggested potential therapeutic avenues for personalized GBM treatment.

8 Oct 2023

3D printing crafts cerebral cortex tissues: A breakthrough for brain injury treatment

Researchers utilize 3D printing to craft cerebral cortex tissues with organized neurons, offering potential treatments for brain injuries. This novel technique prints neural progenitors in layer-by-layer sequences, aiming for accurate tissue restoration in damaged brains.

8 Oct 2023

Gut health and leukemia: Exploring the crucial connection between diet and microbiota changes

Gut microbiota's role in leukemia treatment responses is explored, with evidence suggesting diet and prebiotics may help manage microbiota alterations in patients. Diet during pregnancy, breastfeeding, and gut microbiota composition all intersect, potentially influencing leukemia risks and treatment outcomes.

8 Oct 2023

Study reveals key driver of metabolic rewiring in liver cancer cells

Cancer cells are chameleons. They completely change their metabolism to grow continuously. University of Basel scientists have discovered that high levels of the amino acid arginine drive metabolic reprogramming to promote tumor growth.

6 Oct 2023

Proliferation News and Research

Red grape polyphenol, resveratrol: a multifaceted therapeutic powerhouse under review

HIF-2α inhibitor belzutifan significantly reduces progression of clear cell renal cell carcinoma

Lactobacillus iners in tumors: Driving chemoradiation resistance via lactate-induced metabolic rewiring

Global surge of highly pathogenic avian influenza H5N1

Lactate-producing intratumoral bacteria drive resistance to radiation therapy

Mitochondrial protein CHCHD2 plays important role in glioblastoma progression

Research paves the way for new approach to tackling treatment resistance in cancer

Impact of ketogenic diets on breast cancer

Cracking the code: recent discoveries transform our understanding of cancer-immunity cycle

IL-17: The molecule that could revolutionize autoimmune and cancer treatments

Macrophages play a central role in intestinal cell renewal, study reveals

Discovery of a novel therapeutic target for pancreatic cancer

Halting pandemics at the source: The call for a proactive 'One Health' approach

Study sheds light on PRMT1's role in gastric cancer progression

Midbody remnant found to play role in cancer spread

Blocking TIM-3 checkpoint molecule promotes antitumor immune response in diffuse intrinsic stem glioma

Researchers explore immunomodulating targets for improving glioblastoma therapies

3D printing crafts cerebral cortex tissues: A breakthrough for brain injury treatment

Gut health and leukemia: Exploring the crucial connection between diet and microbiota changes

Study reveals key driver of metabolic rewiring in liver cancer cells

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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