Congenital Heart Disease News and Research

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Metabolic process providing energy to heart muscle fails to mature in babies with hypertrophy

A metabolic process that provides heart muscle with energy fails to mature in newborns with thickened heart walls, according to a Japan-Canada research team.

14 Jun 2018

CVIA publishes special issue on adult congenital heart disease

The new journal Cardiovascular Innovations and Applications has just published the first issue of Volume 3. This is a Special Issue on Adult Congenital Heart Disease with Guest Editor Diego Moguillansky of the University of Florida Medical School.

14 Jun 2018

UNC study provides insight into mechanism of CHD4-related heart defects

Heart defects are the most common type of birth defect, and can be caused by mutations in the gene CHD4. Researchers at the UNC School of Medicine have now revealed key molecular details of how CHD4 mutations lead to heart defects.

12 Jun 2018

Researchers evaluate left ventricular systolic function after pulmonary valve replacement

In the current issue of Cardiovascular Innovations and Applications (Volume3, Number 1, 2018, pp. pp. 21-30(10); DOI 10.15212/CVIA.2017.0050, Ali N. Zaidi and W. Aaron Kay from Columbus Ohio Adult Congenital Heart Disease Program, The Heart Center, Nationwide Children's Hospital and Division of Cardiovascular Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, USA and the Division of Pediatric Cardiology, The Heart Center, Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA consider how following reparative surgery for tetralogy of Fallot or critical pulmonary stenosis, patients frequently present with severe right ventricular volume overload due to pulmonary regurgitation, resulting in decreased RV function.

12 Jun 2018

Study: 2.6% of pediatric patients hospitalized for stroke die in the hospital

A major international study has found that 2.6 percent of infants and children hospitalized for stroke die in the hospital.

5 Jun 2018

Researchers discover how the heart becomes fully developed

Researchers have discovered how the heart develops from a simple tube into its characteristic S-shape and forms ventricles and atria.

4 Jun 2018

MDC researchers provide new insights on embryonic heart development

When it first starts to develop, the heart is a simple tube. Reporting in the journal Nature Communications, researchers at MDC have now described how it forms itself into a its characteristic S-shape and how the ventricles and atria finally develop.

4 Jun 2018

Impaired maternal-fetal environment associated with lower survival after surgery in newborns with CHD

Children who undergo surgery for congenital heart disease have lower survival rates by three years of age if there are specific problems during fetal development, such as hypertension in the mother or the newborn being born preterm or small for gestational age.

30 May 2018

Researchers call for new genetic tests for congenital diseases

Researchers have discovered that genetic mutations called epivariations are the cause of certain neurodevelopmental disorders and congenital diseases.

25 May 2018

Researchers identify novel epigenetic mutations as cause of neurodevelopmental, congenital disorders

Researchers have identified a type of genetic aberration to be the cause of certain neurodevelopmental disorders and congenital diseases, such as autism and congenital heart disease, which are undetectable by conventional genetic testing.

25 May 2018

Experimental molecular therapy to block matrix-forming protein may prevent heart failure

Scientists used an experimental targeted molecular therapy to block a matrix-forming protein in heart cells damaged by heart attack, reducing levels of scarred muscle tissue and saving mouse models from heart failure.

13 Apr 2018

Congenital heart defects in newborns may predict mother's post-pregnancy cardiovascular disease

Women who give birth to infants with congenital heart defects may have an increased risk of cardiovascular hospitalizations later in life, according to new research in the American Heart Association's journal Circulation.

2 Apr 2018

International researchers discover link between congenital heart defects and adrenal gland cancer

An international team led by Dr. Patricia Dahia, M.D., Ph.D., of UT Health San Antonio, discovered a genetic mutation that explains why adults with severe congenital heart defects--who live with low oxygen in their blood--are at dramatically high risk for adrenal gland cancer.

29 Mar 2018

Children from low-income areas have poor outcomes after heart surgery, study finds

Children from low-income neighborhoods had a higher mortality rate and higher hospital costs after heart surgery compared with those from higher-income neighborhoods, found a national study of more than 86,000 kids with congenital heart disease.

24 Feb 2018

Study reveals increased disease risk after early heart surgery

Infections and autoimmune diseases are more common among people who have undergone heart surgery as children and had their thymus removed at the same time, which is often done to get access to the heart. This is evident in a study published in The Journal of Allergy and Clinical Immunology.

21 Feb 2018

Adults with congenital heart disease have increased risk for dementia, study finds

A new study is believed to be the first to show a higher risk of dementia in adults who were born with heart disease.

20 Feb 2018

Vigorous physical activity and fitness needed to cut heart disease risk in teenagers

Guidelines for teenagers should stress the importance of vigorous physical activity and fitness to cut the risk of heart disease, new research suggests. Current NHS guidelines say people aged 5 to 18 should do at least 60 minutes of moderate to vigorous physical activity each day to improve their current and future health.

31 Jan 2018

Researchers uncover powerful new model for studying hallmark of vascular disease

While refining ways to grow arterial endothelial cells in the lab, a regenerative biology team at the Morgridge Institute for Research at the University of Wisconsin-Madison unexpectedly unearthed a powerful new model for studying a hallmark of vascular disease.

9 Jan 2018

Unmarried heart disease patients have higher risk of death

Compared to married heart disease patients, being unmarried was associated with a higher risk of dying, according to new research in Journal of the American Heart Association, the Open Access Journal of the American Heart Association/American Stroke Association.

20 Dec 2017

Higher blood sugar during first trimester of pregnancy increases child's risk of congenital heart defect

Higher blood sugar early in pregnancy raises the baby's risk of a congenital heart defect, even among mothers who do not have diabetes, according to a study led by researchers at the Stanford University School of Medicine.

15 Dec 2017