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Two genetic risk variants in Black individuals may exacerbate sepsis and COVID-19 severity

Two genetic risk variants that are carried by nearly 40 percent of Black individuals may exacerbate the severity of both sepsis and COVID-19, a team of researchers from the University of Pennsylvania's Perelman School of Medicine have found.

16 Nov 2021

Scientists document the spread of atrial fibrillation risk gene across continents and over centuries

University of Utah Health scientists have documented the spread of a disease gene across continents and over centuries.

8 Nov 2021

Identification of a candidate effector gene at COVID-19 risk locus

A new study focuses on developing a comprehensive platform to decode the effects of sequence variation identified by GWAS.

8 Nov 2021

Study looks at how lupus genetics intersects with COVID-19

The study “Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19” was recently published on the preprint medRxiv* server.

8 Nov 2021

Highly-sensitive PCR-based method to detect SARS-CoV-2 variants

A team of UK-based scientists has recently developed an allele-specific probe polymerase chain reaction method that can accurately detect different variants/lineages of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in respiratory samples. Furthermore, the method can detect viral variants even in samples with low viral RNA or degraded viral RNA. The study is currently available on the medRxiv* preprint server.

7 Nov 2021

Experts gain insights into pathomechanisms of dilated cardiomyopathy

Titin is a "titanically large" protein – the largest in the human body – which enables elastic movements of our muscles, including the heart.

6 Nov 2021

Highly-sensitive PCR-based method to detect SARS-CoV-2 variants

A team of scientists has recently developed an allele-specific probe polymerase chain reaction method that can accurately detect different variants/lineages of SARS-CoV-2 in respiratory samples.

4 Nov 2021

Clinical assay validation for SARS-CoV-2 sequencing using Swift Biosciences amplicon panel

The current study used the guidelines of the FDA to validate the one-tube SARS-CoV-2 Swift Normalase Amplicon Panel Version 2.0 from Swift Biosciences.

31 Oct 2021

Genes play a significant role in how the body responds to exercise, finds study

A new study has found that genes play a significant role in how our bodies respond to exercise and has identified a number of specific genes that influence the outcomes of different kinds of physical activity.

15 Oct 2021

Assay for the sensitive and specific identification of SARS-CoV-2 Delta variant

Scientists described a quick and inexpensive method for accurately identifying the Delta variant by applying the double-mismatch allele-specific RT-PCR (DMAS-RT-PCR).

14 Oct 2021

Oxidation-antioxidant imbalance in the blood may be an early indicator of Alzheimer's disease

Research conducted by the Ph.D student Mohamed Raâfet Ben Khedher and the postdoctoral researcher Mohamed Haddad of the Institut national de la recherche scientifique has shown that an oxidation-antioxidant imbalance in the blood is an early indicator of Alzheimer's disease, rather than a consequence.

12 Oct 2021

CRISPR/Cas9-directed epigenetic editing reveals diverse transcriptomic regulation and functional effects

Oncotarget published "Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing" which reported that the adequate functioning of this process is indispensable for tissue homeostasis and cell fate determination.

11 Oct 2021

CDC and ClinGen partner to develop expert curated variant list for the genomic community

The Centers for Disease Control and Prevention's Genetic Testing Reference Material Program (GeT-RM) has partnered with the Clinical Genome Resource (ClinGen) to develop a publicly available list of 546 expert curated pathogenic variants in 84 genes for use in next-generation sequencing (NGS) genetic testing.

11 Oct 2021

Powerful neutralizing antibody against SARS-CoV-2 variants of concern

A new paper discusses a new antibody with potent neutralizing activity against the ancestral SARS-CoV-2 strain, as well as newer variants of SARS-CoV-2.

10 Oct 2021

A possible protective genetic polymorphism in COVID-19

A new study discusses the role of a mucin gene enhancer on the clinical phenotype of the COVID-19.

5 Oct 2021

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Oncotarget published "Comparative microsomal proteomics of a model lung cancer cell line NCI-H23 reveals distinct differences between molecular profiles of 3D and 2D cultured cells" which reported that to ascertain phenotypical differences between these two distinct culture conditions, these authors carried out a comparative proteomic analysis of a membrane fraction obtained from 3D- and 2D-cultured NSCLC model cell line NCI-H23.

29 Sep 2021

Allele News and Research

Two genetic risk variants in Black individuals may exacerbate sepsis and COVID-19 severity

Scientists document the spread of atrial fibrillation risk gene across continents and over centuries

Identification of a candidate effector gene at COVID-19 risk locus

Study looks at how lupus genetics intersects with COVID-19

Highly-sensitive PCR-based method to detect SARS-CoV-2 variants

Experts gain insights into pathomechanisms of dilated cardiomyopathy

Highly-sensitive PCR-based method to detect SARS-CoV-2 variants

Clinical assay validation for SARS-CoV-2 sequencing using Swift Biosciences amplicon panel

Genes play a significant role in how the body responds to exercise, finds study

Assay for the sensitive and specific identification of SARS-CoV-2 Delta variant

Oxidation-antioxidant imbalance in the blood may be an early indicator of Alzheimer's disease

CRISPR/Cas9-directed epigenetic editing reveals diverse transcriptomic regulation and functional effects

CDC and ClinGen partner to develop expert curated variant list for the genomic community

Powerful neutralizing antibody against SARS-CoV-2 variants of concern

A possible protective genetic polymorphism in COVID-19

New analysis reveals distinct differences between molecular profiles of 3D and 2D cultured cells

Chronic COVID-19 and divergent variants of SARS-CoV-2

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

Research explores the evolution and function of human growth hormone receptor gene

A variant analysis approach for SARS-CoV-2 in wastewater samples

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

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