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Metabolite may predict cancer versus autism risk in PTEN patients

In a new study published in American Journal of Human Genetics, a team of researchers led by Charis Eng, M.D., Ph.D., Chair of Cleveland Clinic's Genomic Medicine Institute, identified a metabolite that may predict whether individuals with PTEN mutations will develop cancer or autism spectrum disorder.

26 Sep 2019

NIH grants totaling $2.8 million focus on pinpointing male fertility genes

Pinpointing the genes responsible for male fertility is the focus of two National Institutes for Health grants totaling $2.8 million.

20 Sep 2019

Study uncovers new factor in the development of childhood lymphoma

A study recently published in the renowned journal Blood, led by Kaan Boztug, Scientific Director of the St. Anna Children's Cancer Research Institute, the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Adjunct Principal Investigator at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and Associate Professor at the Medical University of Vienna, together with scientists from Israel, Germany, Turkey, Colombia, Argentina and the USA, investigated four patients from independent families with malignancy, autoimmunity and immunodeficiency.

19 Sep 2019

Genetic testing may help patients with metastatic breast cancer

Breast cancer is a condition wherein the cells in the breast grow uncontrollably. Breast cancer can spread to the other parts of the body, termed as metastatic breast cancer. It is one of the most aggressive and potentially deadly types of cancer.

10 Sep 2019

Lung-MAP study: Majority of cancer patients don't understand genomic test results

A majority of cancer patients don't understand key aspects of the genomic test results they receive as participants in biomarker-driven clinical trials, according to a first-of-its-kind pilot study conducted under the Lung Cancer Master Protocol.

10 Sep 2019

Small-cell clones in epithelial tissues organize differently than their normal-sized counterparts

Small-cell clones in proliferating epithelia – tissues that line all body surfaces – organize very differently than their normal-sized counterparts, according to a recent study from the Stowers Institute for Medical Research.

6 Sep 2019

A new perspective on evolution provided by fly testes

The male testes are important areas for biological innovation, as well as being a factory for sperm. In exciting new biological research a team of scientists has found that the testes are also a hotspot for the production ofnew genes.

19 Aug 2019

Advanced method to accurately detect low-level somatic mutation in intractable epilepsy

KAIST medical scientists have developed an advanced method for perfectly detecting low-level somatic mutation in patients with intractable epilepsy. Their study showed that deep sequencing replicates of major focal epilepsy genes accurately and efficiently identified low-level somatic mutations in intractable epilepsy.

16 Aug 2019

Study reveals Lassa virus' soft spot

As this year's Lassa fever outbreak in Nigeria is finally ebbing, the total tally came to more than 600 infected people, one-quarter of them dead. Thousands more die each year, uncounted in rural villages throughout West Africa.

9 Aug 2019

Ancient epigenetic change deactivates some genes linked to cancer

An epigenetic change, a form of DNA control, that deactivates some genes linked to cancer late in human development has been conserved for more than 400 million years, new research led by the Garvan Institute of Medical Research suggests.

11 Jul 2019

New telementoring program seeks to improve quality of care for breast cancer patients

A new program led by The University of Kansas Cancer Center seeks to improve community oncology providers' knowledge of genetic testing in breast cancer patients, as well as provide tools to allow genetic counseling and testing to be incorporated in their clinical practice.

2 Jul 2019

Identifying colorectal cancer subtypes in patients could help provide better care

Colorectal cancer is the second leading cause of cancer death in the U.S., expected to cause about 51,000 deaths in 2019. But until now, it was unclear which drugs were most effective for which patients.

12 Jun 2019

Russian researcher announces plans to create more CRISPR-edited babies

A researcher has announced controversial plans to create gene-edited babies, dividing the scientific community.

12 Jun 2019

Identifying subtype of colorectal cancer may help oncologists determine most effective treatment

12 Jun 2019

Learned avoidance behavior can be inherited for multiple generations, say Princeton researchers

Princeton University researchers have discovered that learned behaviors can be inherited for multiple generations in C. elegans, transmitted from parent to progeny via eggs and sperm cells.

7 Jun 2019

Men who delay fatherhood put health of partners, unborn children at risk

Men who delay starting a family have a ticking "biological clock" -- just like women -- that may affect the health of their partners and children, according to Rutgers researchers.

13 May 2019

Will gene-editing of human embryos ever be justifiable?

World-leading medical ethicist Professor Arthur Caplan has published a series of recommendations with the aim of addressing worldwide concerns over gene editing of human embryos.

30 Apr 2019

New computer program developed by TGen lights up cancer-causing genetic mutations

By conjuring the spell "Lumos!" wizards in the mythical world of Harry Potter could light up the tip of their magic wands and illuminate their surroundings. So, too, does LumosVar, a computer program developed by the Translational Genomics Research Institute, "light up" cancer-causing genetic Var-ients, or mutations, illuminating how physicians might best treat their patients.

21 Mar 2019

Gene editing and designer babies experiments face global moratorium

Powerful gene editing tools could soon face a global regulations on their use on human embryos, sperms or eggs.

20 Mar 2019

Researchers track effects of epigenetic marks carried by sperm chromosomes

As an organism grows and responds to its environment, genes in its cells are constantly turning on and off, with different patterns of gene expression in different cells. But can changes in gene expression be passed on from parents to their children and subsequent generations?

20 Mar 2019

Germline News and Research

Metabolite may predict cancer versus autism risk in PTEN patients

NIH grants totaling $2.8 million focus on pinpointing male fertility genes

Study uncovers new factor in the development of childhood lymphoma

Genetic testing may help patients with metastatic breast cancer

Lung-MAP study: Majority of cancer patients don't understand genomic test results

Small-cell clones in epithelial tissues organize differently than their normal-sized counterparts

A new perspective on evolution provided by fly testes

Advanced method to accurately detect low-level somatic mutation in intractable epilepsy

Study reveals Lassa virus' soft spot

Ancient epigenetic change deactivates some genes linked to cancer

New telementoring program seeks to improve quality of care for breast cancer patients

Identifying colorectal cancer subtypes in patients could help provide better care

Russian researcher announces plans to create more CRISPR-edited babies

Identifying subtype of colorectal cancer may help oncologists determine most effective treatment

Learned avoidance behavior can be inherited for multiple generations, say Princeton researchers

Men who delay fatherhood put health of partners, unborn children at risk

Will gene-editing of human embryos ever be justifiable?

New computer program developed by TGen lights up cancer-causing genetic mutations

Gene editing and designer babies experiments face global moratorium

Researchers track effects of epigenetic marks carried by sperm chromosomes

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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