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Studies shed new light on leading cause of birth defects and miscarriage

Two recent Northwestern University studies shed new light on the mystery of the leading cause of birth defects and miscarriage, laying the foundation for further research in an understudied but crucially important field of genetic study.

3 Oct 2017

FDA approves FreeStyle Libre Flash Glucose Monitoring System for adult patients with diabetes

The U.S. Food and Drug Administration today approved the FreeStyle Libre Flash Glucose Monitoring System, the first continuous glucose monitoring system that can be used by adult patients to make diabetes treatment decisions without calibration using a blood sample from the fingertip.

27 Sep 2017

First-ever treatment for Merkel cell carcinoma receives approval in Japan

Merck KGaA, Darmstadt, Germany, and Pfizer Inc. today announced that the Japanese Ministry of Health, Labor, and Welfare (MHLW) has approved BAVENCIO (avelumab, genetically recombinant Injection 200mg/mL for intravenous use) as the first and only treatment indicated for curatively unresectable Merkel cell carcinoma (MCC), a rare and aggressive cancer, in Japan.

27 Sep 2017

Researchers use multi-modal integrated approach to develop potential anti-Chagas therapies

Chagas disease is a potentially life-threatening illness caused by the parasite, Trypanosoma cruzi, and is transmitted to humans through triatomine blood-sucking bugs that are commonly referred to as "kissing bugs" or "vampire bugs".

26 Sep 2017

Study presents new method for tracing history of β-cells

Tracing the history of individual cells in the developing organism can reveal functional differences among seemingly uniform cells. This knowledge is important for defining the characteristics of highly regenerative cells in order to target them for cellular therapies, as well as to prevent the formation of unfit cells, which compromise the overall health of the organism.

22 Sep 2017

Researchers identify exosomes as missing link to insulin resistance in type 2 diabetes

Chronic tissue inflammation resulting from obesity is an underlying cause of insulin resistance and type 2 diabetes. But the mechanism by which this occurs has remained cloaked, until now.

21 Sep 2017

Small-molecule immunotherapeutics could steer immune defense against fungal pathogens

Fungal infections represent an increasing health crisis, especially for immune-deficient patients. American scientists now report in the journal Angewandte Chemie that specific help could be provided by small-molecule immunotherapeutics with novel mechanism of action.

21 Sep 2017

'Small intestinal permeable peptides' improve biopharmaceuticals absorption in digestive tract

Biopharmaceuticals, medium- and high-molecular weight biologically active macromolecules, are not easily absorbed by the small intestine, the main organ responsible for gastrointestinal absorption, resulting in a bottleneck for oral administration type biopharmaceutical development.

20 Sep 2017

Scientists take important step toward gene therapy for deaf patients

Scientists at Oregon State University have taken an important step toward gene therapy for deaf patients by developing a way to better study a large protein essential for hearing and finding a truncated version of it.

19 Sep 2017

Research unravels how stem cells in the ovaries may be harnessed to revolutionize fertility treatments

About 13 years ago, Northeastern professor Jonathan Tilly, a reproductive biologist, made a discovery that challenged everything scientists thought they knew about female reproduction. The long-held belief that mammals were born with a set number of eggs -- and no ability to create new ones -- was wrong.

15 Sep 2017

Nanoparticle bling could increase sensitivity of test strips for better cancer detection

The most common test strip people might think of for diagnosis is a home pregnancy test. Pregnant women have steadily increasing levels of the biomarker human chorionic gonadotropin (hCG), which is easily detectable in urine and a thin, colorful strip of antibodies will appear when hCG is present.

13 Sep 2017

Study confirms tattoo nanoparticles migrate around the body

A study conducted by a team of scientists from Germany and the European Synchrotron Radiation Facility (ESRF), France, found that the elements which constitute the tattoos’ ink reach the lymph nodes by travelling inside the body in micro and nanoparticle forms.

13 Sep 2017

Japanese researchers find new way for increasing effectiveness of drug delivery to brain tumors

For a cancer drug to be successful, it needs to reach the malignant tumor site. Researchers in Japan have now found a way for increasing the effectiveness of drug delivery to certain types of brain tumors, by packing epirubicin, a known antitumor agent, in specially designed polymeric micelles.

13 Sep 2017

NIH awards $15 million to develop 3D microphysiological system platforms that model human disease

More than 60 percent of investigational drugs fail in human clinical trials due to a lack of effectiveness, despite promising pre-clinical studies using cell and animal research models.

13 Sep 2017

Phthalate levels in expectant fathers influence sperm epigenetics, study suggests

Early results from a larger, ongoing study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst suggest that phthalate levels in expectant fathers have an effect on couples' reproductive success via epigenetic modifications of sperm DNA.

12 Sep 2017

Human cell-based methods could better identify asthma-causing chemicals, research suggests

Chemicals that could potentially cause asthma through an immune reaction could be better identified with human cell- and computer-based test methods, according to a new research paper co-authored by the Physicians Committee's Kristie Sullivan, M.P.H., in Applied In Vitro Toxicology.

11 Sep 2017

CFDA's NIFDC and IIVS re-affirm, expand partnership to bring non-animal test methods to China

Bo Li, Director General Director of the CFDA's National Institute for Food and Drug Control and Erin Hill, President of US based non-profit, Institute for In Vitro Sciences, Inc., signed a Memorandum of Understanding to bring non-animal test methods to China for the regulation of cosmetics and ingredients.

7 Sep 2017

Differentiating sepsis and systemic inflammatory response syndrome using biomarkers

Firstly, it is necessary to make a distinction between systemic inflammation and Systemic Inflammatory Response Syndrome (SIRS). SIRS consists of changes in clinical signs including an abnormal body temperature, increased heart rate, increased respiratory rate, an abnormal white cell count (either decreased or elevated), or an increase in band neutrophils.

7 Sep 2017

Study describes link between key melanoma signaling pathway and novel class of drugs

Results of a study by The Wistar Institute have described a correlation between a key melanoma signaling pathway and a novel class of drugs being tested in the clinic as adjuvant therapy for advanced melanoma, providing useful information for a more effective use of this type of treatment.

7 Sep 2017

Novel compounds found to be highly effective in preventing transmission of malaria parasites

Significant headway has been made in controlling malaria. However, two vexing problems remain: currently available treatments are unable to block transmission of the parasite that causes the disease, and the parasite often becomes resistant to drugs.

7 Sep 2017

in vitro News and Research

Studies shed new light on leading cause of birth defects and miscarriage

FDA approves FreeStyle Libre Flash Glucose Monitoring System for adult patients with diabetes

First-ever treatment for Merkel cell carcinoma receives approval in Japan

Researchers use multi-modal integrated approach to develop potential anti-Chagas therapies

Study presents new method for tracing history of β-cells

Researchers identify exosomes as missing link to insulin resistance in type 2 diabetes

Small-molecule immunotherapeutics could steer immune defense against fungal pathogens

'Small intestinal permeable peptides' improve biopharmaceuticals absorption in digestive tract

Scientists take important step toward gene therapy for deaf patients

Research unravels how stem cells in the ovaries may be harnessed to revolutionize fertility treatments

Nanoparticle bling could increase sensitivity of test strips for better cancer detection

Study confirms tattoo nanoparticles migrate around the body

Japanese researchers find new way for increasing effectiveness of drug delivery to brain tumors

NIH awards $15 million to develop 3D microphysiological system platforms that model human disease

Phthalate levels in expectant fathers influence sperm epigenetics, study suggests

Human cell-based methods could better identify asthma-causing chemicals, research suggests

CFDA's NIFDC and IIVS re-affirm, expand partnership to bring non-animal test methods to China

Differentiating sepsis and systemic inflammatory response syndrome using biomarkers

Study describes link between key melanoma signaling pathway and novel class of drugs

Novel compounds found to be highly effective in preventing transmission of malaria parasites

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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