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Physicians graduated outside the U.S. offer better care for Medicare patients with complex needs

A study by a Massachusetts General Hospital research team indicates that internal medicine physicians who are graduates of medical schools outside the U.S. care for Medicare patients with more complex medical needs than those cared for by graduates of American medical schools.

20 Feb 2019

First molecular test predicts treatment response for kidney cancer

Immunotherapy drugs such as PD-L1 checkpoint inhibitors represent the front-line treatment for kidney cancer. But immunotherapy is expensive, benefits only a subset of patients and is futile in the majority of patients.

19 Feb 2019

Study shows how 3D organization of genetic material helps perpetuate the species

From fathers to children, the delivery of hereditary information requires the careful packing of DNA in sperm. But just how nature packages this DNA to prepare offspring isn't clear.

19 Feb 2019

Researchers identify multiple genetic variants associated with body fat distribution

A new breakthrough from the Genetic Investigation of Anthropometric Traits consortium, which includes many public health researchers from the University of North Carolina at Chapel Hill, identifies multiple genetic variants associated with how the body regulates and distributes body-fat tissue.

18 Feb 2019

Scientists discover trigger that turns strep infections into devastating disease

Houston Methodist infectious disease scientists have discovered a previously unknown trigger that turns a relatively run-of-the-mill infection into a devastatingly ravenous, flesh-eating disease.

18 Feb 2019

Columbia researchers unravel why some glioblastomas respond to immunotherapy

Columbia researchers have learned why some glioblastomas--the most common type of brain cancer--respond to immunotherapy. The findings could help identify patients who are most likely to benefit from treatment with immunotherapy drugs and lead to the development of more broadly effective treatments.

17 Feb 2019

Whole-genome sequencing and sharing real-time data could limit spread of foodborne bacteria

Employing advanced genetic-tracing techniques and sharing the data produced in real time could limit the spread of bacteria -- Bacillus cereus -- which cause foodborne illness, according to researchers who implemented whole-genome sequencing of a pathogen-outbreak investigation.

14 Feb 2019

Photoacoustic imaging accurately measures the temperature of deep tissues

Measuring a fever is usually pretty simple: place a thermometer under a patient's tongue and get an accurate temperature reading within 30 seconds. But that simplicity does not translate when it comes to measuring the temperatures of specific tissues deep inside the body.

14 Feb 2019

Novel approach uses small amounts of tissue to quantify PD-L1 expression levels in tumors

Immune checkpoint inhibitors, such as the anti-PD-1 antibody pembrolizumab, have become important tools for managing non-small-cell lung cancer.

14 Feb 2019

Increased activity of EHMT2 gene deficient neurons could cause autism in humans

A novel investigation into the impacts of neuronal mutations on autism-related characteristics in humans has been described in the open-access journal eLife.

13 Feb 2019

Relapse dreams more common in people with severe alcohol, drug addiction history

Vivid dreams involving drinking and drug use are common among individuals in recovery. A study from the Massachusetts General Hospital Recovery Research Institute, published in the January issue of the Journal of Substance Abuse Treatment after online release in October 2018, finds these relapse dreams are more common in those with more severe clinical histories of alcohol and other drug problems.

13 Feb 2019

Mountain chickadee research shows link between natural selection and spatial memory

Chickadees with better learning and memory skills, needed to find numerous food caches, are more likely to survive their first winter, a long-term study of mountain chickadees has found.

13 Feb 2019

New process efficiently reprograms stem cells in one step using measles virus vector

Induced pluripotent stem cells, the workhorse of many regenerative medicine projects, start out as differentiated cells that are reprogrammed to pluripotent stem cells by exposure to a complex set of genetic cocktails.

13 Feb 2019

Comparison of cancer genes across species helps prioritize targets for new cancer therapies

Cancer genes in mucosal melanoma, a rare and poorly understood subtype of melanoma, have been compared in humans, dogs and horses for the first time by scientists at the Wellcome Sanger Institute and their collaborators.

12 Feb 2019

NIH scientists zero in on genes associated with AMD

National Eye Institute scientists led a collaborative study and zeroed in on genes associated with age-related macular degeneration, a leading cause of vision loss and blindness among people age 65 and older.

12 Feb 2019

MGH researchers identify brain cells that modulate behavioral response to threats

A team of investigators from the Massachusetts General Hospital (MGH) Center for Regenerative Medicine has identified a population of brain cells that appears to play a role in calibrating behavioral responses to potentially threatening situations.

12 Feb 2019

Research reveals critical immunological axis that triggers cancer-promoting chronic inflammation

A Massachusetts General Hospital research team has identified interaction between two elements of the immune system as critical for the transformation of a protective immune response into chronic, cancer-promoting inflammation.

12 Feb 2019

Scientists develop machine-learning approach to identify source of Salmonella

A team of scientists led by researchers at the University of Georgia Center for Food Safety in Griffin has developed a machine-learning approach that could lead to quicker identification of the animal source of certain Salmonella outbreaks.

12 Feb 2019

Individualized diets more effective in controlling blood glucose levels, study finds

An individualized diet based on a person's genetics, microbiome and lifestyle is more effective in controlling blood glucose (sugar) levels than one that considers only nutritional composition of food, Mayo Clinic researchers have confirmed.

11 Feb 2019

When genomic sequencing fails to diagnose a rare disease

Routine sequencing has given unprecedented insight into the genetics of rare diseases, but genomics fails to diagnose up to half of patients who are tested. That's the problem German scientists tackled in a recent study in the journal Molecular & Cellular Proteomics.

11 Feb 2019

Genomic News and Research

Physicians graduated outside the U.S. offer better care for Medicare patients with complex needs

First molecular test predicts treatment response for kidney cancer

Study shows how 3D organization of genetic material helps perpetuate the species

Researchers identify multiple genetic variants associated with body fat distribution

Scientists discover trigger that turns strep infections into devastating disease

Columbia researchers unravel why some glioblastomas respond to immunotherapy

Whole-genome sequencing and sharing real-time data could limit spread of foodborne bacteria

Photoacoustic imaging accurately measures the temperature of deep tissues

Novel approach uses small amounts of tissue to quantify PD-L1 expression levels in tumors

Increased activity of EHMT2 gene deficient neurons could cause autism in humans

Relapse dreams more common in people with severe alcohol, drug addiction history

Mountain chickadee research shows link between natural selection and spatial memory

New process efficiently reprograms stem cells in one step using measles virus vector

Comparison of cancer genes across species helps prioritize targets for new cancer therapies

NIH scientists zero in on genes associated with AMD

MGH researchers identify brain cells that modulate behavioral response to threats

Research reveals critical immunological axis that triggers cancer-promoting chronic inflammation

Scientists develop machine-learning approach to identify source of Salmonella

Individualized diets more effective in controlling blood glucose levels, study finds

When genomic sequencing fails to diagnose a rare disease

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