Polymerase News and Research

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Invitrogen and Agilent Technologies resolve all pending patent litigations

Invitrogen Corporation and Agilent Technologies have jointly announced a confidential settlement of multiple patent litigations pending between the two companies.

5 Feb 2008

Evolutionary 'battle scars' identify enhanced antiviral activity

Rapid evolution of a protein produced by an immunity gene is associated with increased antiviral activity in humans, a finding that suggests evolutionary biology and virology together can accelerate the discovery of viral-defense mechanisms, according to researchers at Fred Hutchinson Cancer Research Center.

25 Jan 2008

Cancer stem cell marker also drives transcription in normal cells

New research links the recently discovered function of a multi-faceted transcriptional complex to control of gene expression in both normal cells and cancer stem cells.

18 Jan 2008

New method to identify genetic determinants of Alzheimer's

A rapid and accurate DHPLC assay for determination of apolipoprotein E genotypes has been developed by researchers from the Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

14 Jan 2008

New understanding on the mechanics of gene transcription

The molecular machinery behind gene transcription -- the intricate transfer of information from a segment of DNA to a corresponding strand of messenger RNA -- isn't stationed in special "transcription factories" within a cell nucleus, according to Cornell researchers.

9 Jan 2008

Copy number variation may stem from replication misstep

Genome rearrangements, resulting in variations in the numbers of copies of genes, occur when the cellular process that copies DNA during cell division stalls and then switches to a different genetic "template," said researchers at Baylor College of Medicine in Houston in a report that appears today in the journal Cell.

28 Dec 2007

Evolution with a restricted number of genes

The development of higher forms of life would appear to have been influenced by RNA polymerase II.

17 Dec 2007

RNA polymerase III mutation disrupts organ growth

The cellular mechanism that turns DNA into all of the thousands of proteins that make up a human body is itself both intricate and interesting.

27 Nov 2007

WaferGen and University of Pittsburgh to collaborate on SmartChip

WaferGen Biosystems, Inc. has announced that it has established a research collaboration with the University of Pittsburgh Medical School to have it serve as the alpha test site for WaferGen's SmartChip Real-Time PCR System.

14 Nov 2007

Chemical peroxynitrite tolerates pain

The repeated use of opiate drugs such as morphine to relieve chronic pain results in individuals having to take higher and higher doses of the drug to achieve equivalent pain relief (they are said to exhibit antinociceptive tolerance).

2 Nov 2007

Regulation of TATA-less promoters

In their upcoming G&D paper, Dr. Robert Tjian (UC Berkeley) and colleagues reveal how histone gene expression is differentially regulated during Drosophila development.

2 Nov 2007

Significant improvement over current test for human papillomavirus

Iowa State University researchers have developed a technology that detects a single molecule of the virus associated with cervical cancer in women.

31 Oct 2007

Red hair and freckles - Neanderthals in Europe

Fossil remains of Neanderthals paint an incomplete picture; they cannot tell us about their cognitive skills or give us details of what they looked like.

28 Oct 2007

Abbott creates one molecule with two antibody functions

Abbott has reported that its scientists are the first to discover a proprietary technology that combines the function and specificity of two or more monoclonal antibodies (mAbs) into one molecular entity that demonstrates drug-like properties and manufacturing feasibility.

19 Oct 2007

Newly solved structure reveals how cells resist oxygen damage

The sun's rays give life, but also take it away. Singlet oxygen, a byproduct of the photosynthetic process by which certain cells convert sunlight into energy, is a highly toxic and reactive substance that tears cells apart.

16 Oct 2007

Direct selection of human genomic loci by microarray hybridization

Researchers at Baylor College of Medicine and Roche NimbleGen Inc., a fully integrated part of Roche Applied Science, have published details of a highly efficient and cost-effective method for capturing targeted regions of the genome via NimbleChip microarrays in preparation for high-throughput 454 Sequencing.

16 Oct 2007