Small Intestine News and Research

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'Small intestinal permeable peptides' improve biopharmaceuticals absorption in digestive tract

Biopharmaceuticals, medium- and high-molecular weight biologically active macromolecules, are not easily absorbed by the small intestine, the main organ responsible for gastrointestinal absorption, resulting in a bottleneck for oral administration type biopharmaceutical development.

20 Sep 2017

Researchers develop new model to tackle patients with cryptosporidiosis-HIV co-infection

One of the most common waterborne diseases worldwide is cryptosporidiosis, a parasitic disease affecting the small intestine and possibly our airways. It is a common cause of diarrhoea in HIV-positive patients, who are known to have lower immunity.

13 Sep 2017

New mathematical model accurately forecasted when cholera epidemic would peak in Yemen

Hokkaido University scientists has developed a new mathematical model which accurately forecasted that a devastating cholera epidemic in Yemen would peak by early July, the 26th week of 2017 and the cumulative incidence would be the order of 700-800 thousand cases.

26 Aug 2017

Research shows probiotics can reduce incidence of sepsis in infants

A research team at the University of Nebraska Medical Center College of Public Health has determined that a special mixture of good bacteria in the body reduced the incidence of sepsis in infants in India by 40 percent at a cost of only $1 per infant.

16 Aug 2017

Two new studies expand understanding of link between PD and gastrointestinal dysfunction

Constipation is one of the most common non-motor related complaints affecting Parkinson's disease (PD) patients. Two important studies from the same research group published in the Journal of Parkinson's Disease expand the understanding of the relationship between PD and gastrointestinal dysfunction.

31 Jul 2017

Scientists reveal key role of excess gut calcium in C. diff infections

It lurks in hospitals and nursing homes, surviving the cleaning crew's attempt to kill it by holing up in a tiny hard shell. It preys upon patients already weak from disease or advanced age.

13 Jul 2017

Singapore researchers discover new mechanism in the liver's response to blocked bile ducts

A multi-disciplinary team of researchers from the Mechanobiology Institute, Singapore at the National University of Singapore, the Institute of Bioengineering and Nanotechnology of A*STAR, and BioSyM, Singapore-MIT Alliance for Research and Technology have described the mechanical principles adopted by liver cells as they remove excess bile during obstructive cholestasis.

30 Jun 2017

Novel procedure to seal off lymphatic fluid leaks improves symptoms in patients with single-ventricle disease

Focusing on a rare but devastating complication in patients with single-ventricle heart disease, a research team has revealed the role of leakage from the liver's lymphatic system, and used a novel procedure to seal off those leaks and improve symptoms in patients.

29 Jun 2017

Proton pump inhibitors do not increase risk for dementia or Alzheimer's disease

Proton pump inhibitors (PPIs) are medications used to treat digestive problems such as ulcers and reflux disease by reducing the body's production of the acid that helps us digest food.

22 Jun 2017

Study shows how high fat diets can alter gut bacteria to combat harmful inflammation

Researchers at Case Western Reserve University School of Medicine have shown a high fat diet may lead to specific changes in gut bacteria that could fight harmful inflammation--a major discovery for patients suffering from Crohn's disease.

22 Jun 2017

'Mismatch repair' genetic defects drive cancer patient's response to immunotherapy drugs

In an expanded, three-year clinical trial of 86 patients with colorectal and 11 other kinds of cancer that have so-called 'mismatch repair' genetic defects, scientists at Johns Hopkins Medicine and its Bloomberg~Kimmel Institute for Cancer Immunotherapy have found that half of the patients respond to an immunotherapy drug called pembrolizumab.

9 Jun 2017

Opioid use gradually increases few years after bariatric surgery, study shows

While the proportion of adults with severe obesity using prescription opioids initially declines in the months after bariatric surgery, it increases within a matter of years, eventually surpassing pre-surgery rates of patients using the potentially addictive pain medications, according to new research from a National Institutes of Health -funded multicenter study led by the University of Pittsburgh Graduate School of Public Health.

6 Jun 2017

MGH scientists show how Shigella survives journey from mouth to the colon

Surviving the treacherous journey through the human body from the mouth to the colon takes a special kind of bacterial pathogen.

31 May 2017

Kyoto University researchers identify specific gene as key regulator in iron uptake

Maintaining a good balance of iron in the body is necessary for health: too little can lead to anemia, but too much can cause debilitating disorders such as hemochromatosis.

30 May 2017

One in five bariatric surgery patients likely to develop alcohol problems, study finds

One in five patients who undergo one of the most popular weight-loss surgical procedures is likely to develop problems with alcohol, with symptoms sometimes not appearing until years after their surgery, according to one of the largest, longest-running studies of adults who got weight-loss surgery.

16 May 2017

Solid or tube feeding early in pancreatitis may help reduce hospital stays, research finds

When the excruciating pain of a pancreas attack sends someone to the hospital, eating is probably the last thing they're thinking of. And for decades, medical teams have kept such patients away from solid food for days.

16 May 2017

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

ImmusanT, Inc., a clinical-stage company developing Nexvax2, a therapeutic vaccine intended to protect against the effects of gluten exposure while maintaining a gluten-free diet in HLA-DQ2.5+ patients with celiac disease, today announced the publication of positive data from two Phase 1 clinical trials of Nexvax2 in celiac disease.

12 May 2017