Metabolic Disorders News and Research

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Scientists discover protective mechanism against atherosclerosis

Atherosclerosis, the pathological narrowing of blood vessels, is the underlying cause for the majority of strokes and heart attacks, the major causes of mortality worldwide according to the WHO.

12 Jun 2018

Teens and young adults with type 1 diabetes often experience stigma

Michael Wright was your average high school student, juggling the responsibilities of school and friends while taking the first steps towards finding his first real job.

12 Jun 2018

Synthetic gene reveals potential therapeutic target for rare, inherited disease

DNA Repair is essential for a healthy organism. In every day of our lives, tens of thousands of damages occur in the genetic material of our cells. Hence, it is not surprising that a broad variety of repair mechanisms developed in the course of evolution that enables cells to quickly react and patch up the affected DNA strands.

11 Jun 2018

Microbiotica collaborates with Genentech to develop drugs for IBD

Microbiotica, a leading player in microbiome-based therapeutics spun out of the Wellcome Sanger Institute, today announced that it has entered into a multi-year strategic collaboration with Genentech, a member of the Roche Group, to discover, develop and commercialize biomarkers, targets and medicines for inflammatory bowel disease.

6 Jun 2018

Researchers reveal role NAD+ molecule in turning on genes that make fat cells

Glucose is the energy that fuels cells, and the body likes to store glucose for later use. But too much glucose can contribute to obesity, and scientists have long wanted to understand what happens within a cell to tip the balance.

1 Jun 2018

Reducing exposure to hormone interfering chemicals may mitigate obesity risk

Everyday products carry environmental chemicals that may be making us fat by interfering with our hormones, according to research presented in Barcelona at the European Society of Endocrinology annual meeting, ECE 2018.

21 May 2018

Scientists identify new potential target to combat acute myeloid leukemia

AML is not a single disease. It is a group of leukemias that develop in the bone marrow from progenitors of specialized blood cells, the so-called myeloid cells. Rapidly growing and dividing, these aberrant cells crowd the bone marrow and bloodstream, which can be fatal within weeks or months if the disease is left untreated.

18 May 2018

Raising Awareness of Childhood Dementia

The Dementia Strikes Children Too campaign aims to raise awareness of childhood dementia, drive for better clinical education of this group of diseases, and put in place the systems and tools for earlier diagnosis.

18 May 2018

Infant formulas containing fructose pose risk to babies with hereditary fructose intolerance

Babies with inherited intolerance of fructose face a risk of acute liver failure if they are fed certain widely available formulas containing fructose, pediatricians and geneticists are warning.

18 May 2018

Study provides insights into how immune cells kill bacteria with acid

The first line of immune defense against invading pathogens like bacteria are macrophages, immune cells that engulf every foreign object that crosses their way. After enclosing it in intracellular membrane vesicles, a process called phagocytosis, macrophages kill their prey with acid.

17 May 2018

Findings confirm analytical principle that describes mutational processes and cancer development

When a cell develops into a tumor, something has gone terribly wrong: the uncontrolled growth, invasion of nearby tissues and finally metastasis are the result of many consecutive DNA mutations.

9 May 2018

Nuclear pore complexes are critical for survival of circulating T cells, study shows

Nuclear pore complexes in the nuclear membrane not only control the transport of molecules into and out of the nucleus- they play an essential role in the survival of T cells.

8 May 2018

Study provides vital information to develop successful PI5P4K inhibitors for p53-mutant cancers

One major hallmark of cancer cells is their ability to adapt to stressful conditions such as nutrient deprivation. Rapidly growing tumor cells must compete for the ever-diminishing supply of nutrients in the surrounding environment to survive and proliferate. Targeting these adaptive mechanisms represents a promising approach for cancer therapeutics.

3 May 2018

Study explains how colon cancer cells spread to the liver

Colorectal cancer is the third most common cancer worldwide and the third-leading cause of cancer-related deaths. The main cause of death in patients with colorectal cancer is liver metastasis, with nearly 70% of patients eventually developing a liver tumor.

25 Apr 2018

Regular soaking in hot tub improves health outlook in obese women with PCOS

According to new research, obese women with polycystic ovary syndrome may be able to improve their health outlook with a particularly enjoyable form of therapy: regular sessions in a hot tub.

25 Apr 2018

Study proposes new mechanism that may contribute to gender differences in weight control

For years, scientists have observed that when male and female mice eat the same high-fat diet, the males gain significantly more weight than the females.

18 Apr 2018

Breastfeeding mothers who overeat may increase risk of health problems in offspring

Mothers who overeat during the period when they are breastfeeding may have children who are at increased risk of becoming obese and going through early puberty, a new study of mice suggests.

19 Mar 2018

Boosting the brain's immune cells may prevent or reduce severity of Alzheimer's disease

Sanford Burnham Prebys Medical Research Institute researchers have published two new studies in Neuron that describe how TREM2, a receptor found on immune cells in the brain, interacts with toxic amyloid beta proteins to restore neurological function.

8 Mar 2018

New study provides better understanding of asymmetric cell division

Stem cells are the basic material from which mature, specialised cells such as muscle and blood cells are produced -- this process is known as differentiation.

28 Feb 2018

Altered immune cell clocks may contribute to metabolic diseases in shift workers

About 15 million Americans don't have a typical nine-to-five workday, and many of these--nurses, firefighters and flight attendants, among many other professions--may see their schedule change drastically one week to the next.

7 Feb 2018

Metabolic Disorders News and Research

Scientists discover protective mechanism against atherosclerosis

Teens and young adults with type 1 diabetes often experience stigma

Synthetic gene reveals potential therapeutic target for rare, inherited disease

Microbiotica collaborates with Genentech to develop drugs for IBD

Researchers reveal role NAD+ molecule in turning on genes that make fat cells

Reducing exposure to hormone interfering chemicals may mitigate obesity risk

Scientists identify new potential target to combat acute myeloid leukemia

Raising Awareness of Childhood Dementia

Infant formulas containing fructose pose risk to babies with hereditary fructose intolerance

Study provides insights into how immune cells kill bacteria with acid

Findings confirm analytical principle that describes mutational processes and cancer development

Nuclear pore complexes are critical for survival of circulating T cells, study shows

Study provides vital information to develop successful PI5P4K inhibitors for p53-mutant cancers

Study explains how colon cancer cells spread to the liver

Regular soaking in hot tub improves health outlook in obese women with PCOS

Study proposes new mechanism that may contribute to gender differences in weight control

Breastfeeding mothers who overeat may increase risk of health problems in offspring

Boosting the brain's immune cells may prevent or reduce severity of Alzheimer's disease

New study provides better understanding of asymmetric cell division

Altered immune cell clocks may contribute to metabolic diseases in shift workers

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