Amyotrophic Lateral Sclerosis (ALS) News and Research

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Patent covering methods of treating ALS receives notice of allowance

Neuralstem, Inc. announced today that it received a notice of allowance for patent application 12/404,841. This patent covers methods for treating amyotrophic lateral sclerosis (ALS or Lou Gehrig 's disease) with expanded spinal cord stem cells, including NSI-566.

6 Apr 2013

Clinical trial signals new era in treatment of neurodegererative disorders

The initial clinical trial of a novel approach to treating amyotrophic lateral sclerosis - blocking production of a mutant protein that causes an inherited form of the progressive neurodegererative disease - may be a first step towards a new era in the treatment of such disorders.

4 Apr 2013

Johns Hopkins scientists identify role of central nervous system cell in development of ALS

Johns Hopkins scientists say they have evidence from animal studies that a type of central nervous system cell other than motor neurons plays a fundamental role in the development of amyotrophic lateral sclerosis, a fatal degenerative disease.

1 Apr 2013

Exosomes can transfer membrane proteins, study reveals

Important new research from UMass Medical School demonstrates how exosomes shuttle proteins from neurons to muscle cells where they take part in critical signaling mechanisms, an exciting discovery that means these tiny vehicles could one day be loaded with therapeutic agents, such as RNA interference, and directly target disease-carrying cells.

28 Mar 2013

Gladstone investigator to receive Essey Award for fight against amyotrophic lateral sclerosis

Shinya Yamanaka, MD, PhD, a senior investigator at the Gladstone Institutes, next month will receive the Essey Award for his "Commitment to a Cure" from The ALS Association Golden West Chapter.

26 Mar 2013

Rensselaer professor awarded NIH grant to explore cellular function with links to diverse diseases

The interior of every cell within our bodies is crisscrossed with a network of molecular highways upon which nutrients, replacement parts, and other vital materials travel to their appropriate location.

20 Mar 2013

Genetic testing services for rare neurological disorders launched by Athena Diagnostics

Athena Diagnostics, a leader in neurological diagnostics, today announced the clinical availability of new genetic tests to aid the detection of several rare neurological disorders, including hereditary neuropathy, neuromuscular disease, epilepsy and certain movement disorders. The lab-developed tests are available through Athena Diagnostics, a business of Quest Diagnostics (NYSE:DGX), the world’s leading provider of diagnostic information services.

From Quest Diagnostics 19 Mar 2013

VCP gene mutations cause neurological conditions including IBMPFD and ALS

New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget's Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS).

14 Mar 2013

Researchers identify new mechanism in onset of motor neuron diseases

The British astrophysicist Stephen Hawking is likely to be the world's most famous person living with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. ALS is a progressive disease affecting motor neurons, nerve cells that control muscle function, and nearly always leads to death.

11 Mar 2013

‘New Frontiers in Neurodegenerative Disease Research’ symposium to be held from Feb. 4-7

At the Keystone Symposium "New Frontiers in Neurodegenerative Disease Research," held 4-7 February in Santa Fe, New Mexico, researchers explored the processes that lead to a variety of diseases, including Alzheimer's and Lou Gehrig's disease (amyotrophic lateral sclerosis, ALS).

7 Mar 2013

Researchers discover new candidate disease proteins for neurodegenerative disorders

A multi-institution group of researchers has found new candidate disease proteins for neurodegenerative disorders.

4 Mar 2013

Study identifies how new ALS gene mutations cause other diseases of the brain, muscle and bone

Researchers supported by The ALS Association have discovered how mutations in new amyotrophic lateral sclerosis (ALS) genes cause not only ALS but also other diseases of the brain, muscle and bone.

4 Mar 2013

Study identifies two gene mutations that lead to death of nerve cells in ALS

A study led by St. Jude Children's Research Hospital has discovered mutations in two genes that lead to the death of nerve cells in amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and related degenerative diseases.

4 Mar 2013

NINDS to award TSRI scientist with $3.5M Jacob K. Javits Neuroscience Investigator Award

Ron Davis, PhD, chair of the Neuroscience Department on the Florida campus of The Scripps Research Institute, has been selected to receive a prestigious $3.5 million Jacob K. Javits Neuroscience Investigator Award for his work on the complex biology of memory formation and the disorders that disrupt it.

21 Feb 2013

Study finds abnormal production of C9RANT in patients with ALS, frontotemporal dementia

Researchers at Mayo Clinic have discovered an abnormal protein that accumulates in the brains of many patients affected with two common neurodegenerative disorders — amyotrophic lateral sclerosis, also known as ALS or Lou Gehrig's disease, and frontotemporal dementia.

13 Feb 2013

Scientists identify enigmatic aggregates linked to neurodegenerative diseases

The proteins that have now been identified shouldn't actually exist. Nevertheless, they build the core of cellular aggregates whose identity has been enigmatic until now. These aggregates are typically associated with hereditary neurodegenerative diseases including variants of frontotemporal dementia (FTD), also known as frontotemporal lobar degeneration (FTLD), and amyotrophic lateral sclerosis (ALS). They are likely to be damaging and might be a target for therapy.

11 Feb 2013

Occupational exposure to magnetic fields may moderately increase risk of Alzheimer's, ALS

Occupational exposure to magnetic fields (MF) may be associated with "moderately increased risk" of certain neurodegenerative diseases—including Alzheimer's and amyotrophic lateral sclerosis, reports the February Journal of Occupational and Environmental Medicine, official publication of the American College of Occupational and Environmental Medicine (ACOEM).

7 Feb 2013

Amyotrophic Lateral Sclerosis (ALS) News and Research

Patent covering methods of treating ALS receives notice of allowance

Clinical trial signals new era in treatment of neurodegererative disorders

Johns Hopkins scientists identify role of central nervous system cell in development of ALS

Exosomes can transfer membrane proteins, study reveals

Gladstone investigator to receive Essey Award for fight against amyotrophic lateral sclerosis

Rensselaer professor awarded NIH grant to explore cellular function with links to diverse diseases

Genetic testing services for rare neurological disorders launched by Athena Diagnostics

VCP gene mutations cause neurological conditions including IBMPFD and ALS

Researchers identify new mechanism in onset of motor neuron diseases

‘New Frontiers in Neurodegenerative Disease Research’ symposium to be held from Feb. 4-7

Researchers discover new candidate disease proteins for neurodegenerative disorders

Study identifies how new ALS gene mutations cause other diseases of the brain, muscle and bone

Study identifies two gene mutations that lead to death of nerve cells in ALS

NINDS to award TSRI scientist with $3.5M Jacob K. Javits Neuroscience Investigator Award

Study finds abnormal production of C9RANT in patients with ALS, frontotemporal dementia

Scientists identify enigmatic aggregates linked to neurodegenerative diseases

Occupational exposure to magnetic fields may moderately increase risk of Alzheimer's, ALS

Eating brightly colored fruit and veg may help prevent ALS

Consuming carotenoid-rich foods may help prevent or delay onset of amyotrophic lateral sclerosis

Researchers to develop new diagnostic tools and treatments for people with rare diseases

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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