Metabolic Disorders News and Research

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SBP researchers identify new protective function for brain protein genetically linked to Alzheimer's

Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a new protective function for a brain protein genetically linked to Alzheimer's. The findings, published in the Journal of Experimental Medicine, could inform novel treatment strategies.

7 Nov 2017

Study elucidates how obesity makes breast cancer more aggressive

Obesity leads to the release of cytokines into the bloodstream which impact the metabolism of breast cancer cells, making them more aggressive as a result. Scientists from Helmholtz Zentrum München, Technische Universität München, and Heidelberg University Hospital report on this in 'Cell Metabolism'. The team has already been able to halt this mechanism with an antibody treatment.

23 Oct 2017

TSRI study offers key insights into possible links between sleep and hunger

A new study from scientists on the Florida campus of The Scripps Research Institute offers important insights into possible links between sleep and hunger-;and the benefits of studying the two in tandem.

13 Oct 2017

Crown Bioscience announces availability of new translational models for obesity and diabetes in Europe

Crown Bioscience, a wholly-owned subsidiary of Crown Bioscience International and a global drug discovery and development services company providing translational platforms to advance oncology, inflammation, cardiovascular and metabolic disease research, announces the availability of their proprietary FATZO model in a European based laboratory.

12 Oct 2017

Study provides insights into non-oncogenic addictions of tumors

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego have shown that tumors can ensure a more reliable nutrient supply by eliminating the p62 protein in surrounding stromal tissue.

9 Oct 2017

Unique conference aims at preventing major diseases and extending healthy lifespan

The program for the first assembly of the World Congress on Targeting Metabesity is now available at www.metabesity2017.com. Metabesity refers to the major public health challenges—cardiovascular disease, cancer, dementia, diabetes and the aging process itself—all of which share metabolic roots.

4 Oct 2017

SBP researcher awarded $10.8 million grant to pursue development of new drug for substance abuse

Sanford Burnham Prebys Medical Discovery Institute is pleased to announce the National Institute on Drug Abuse at the National Institutes of Health has awarded Nicholas Cosford, Ph.D., a three-year, $10.8 million grant to pursue the preclinical development of a new class of medicine to treat substance use disorders.

26 Sep 2017

New sickle cell disease poll dispels long-held perceptions of African Americans

Pfizer Inc., the National Newspaper Publishers Association, and scholars from Howard University today announced results from a new national poll designed to deepen understanding and gauge perceptions around sickle cell disease (SCD) among African Americans.

21 Sep 2017

Physical stress in preemies plus separation from mothers may have lasting effects into adulthood

A new study suggests that physiological stress in premature infants combined with separation from their mothers may have lasting effects into adulthood.

20 Sep 2017

A skin patch to get rid of those love handles

Researchers from the Columbia University Medical Center (CUMC) and the University of North Carolina have managed to devise a microneedle skin patch that could locally treat both obesity and diabetes. As of now it has been used to treat mice in the laboratory and shown promising results.

17 Sep 2017

Unfolded protein response could be cause of metabolic disorders, say researchers

The cell's response to unfolded or misfolded proteins could be a cause, rather than a consequence, of metabolic disorders, report researchers at the Medical University of South Carolina in an article published online ahead of print on September 4, 2017 by Nature Structural & Molecular Biology.

4 Sep 2017

Protein intake three times a day could be linked to greater mass, muscle strength in the elderly

Loss of muscle is an inevitable consequence of aging that can lead to frailty, falls or mobility problems. Eating enough protein is one way to remedy it, but it would seem that spreading protein equally among the three daily meals could be linked to greater mass and muscle strength in the elderly.

31 Aug 2017

Heat therapy could be promising treatment to help fight against cancer, autoimmune problems

Heat therapy may be a promising treatment in the fight against cancer, autoimmune problems and efforts to avoid organ rejection in transplant patients, according to researchers at the University of Kentucky.

30 Aug 2017

SBP scientist receives DoD award to identify new and efficacious treatments for pancreatic cancer

Sanford Burnham Prebys Medical Discovery Institute is pleased to announce that the Department of Defense (DoD) has awarded Cosimo Commisso, Ph.D., a Career Development Award to identify new and efficacious treatments for pancreatic cancer.

29 Aug 2017

Pfizer announces launch two new digital innovations to help people living with hemophilia

Pfizer Inc. today announced the launch of Hemocraft, a modification of the popular video game Minecraft, and the HemMobile Striiv Wearable, a custom wristband, to help people living with hemophilia better approach hemophilia education and activity tracking in the US.

26 Aug 2017

Enhanced levels of NPs in adipose tissue protect against obesity and insulin resistance

Researchers at Sanford Burnham Prebys Medical Discovery Institute in Lake Nona, Florida have shown that enhanced natriuretic peptide (NP) signaling in adipose tissue protects against obesity and insulin resistance.

26 Aug 2017

Researchers develop proof-of-concept nanosystem to enhance visualization of tumors

Researchers at Sanford Burnham Prebys Medical Discovery Institute have developed a proof-of-concept nanosystem that dramatically improves the visualization of tumors.

24 Aug 2017

Id genes found to play crucial role in heart development

Researchers from Sanford Burnham Prebys Medical Discovery Institute (SBP), the Cardiovascular Institute at Stanford University and other institutions were surprised to discover that the four genes in the Id family play a crucial role in heart development, telling undifferentiated stem cells to form heart tubes and eventually muscle.

22 Aug 2017

Study: Liver inflammation increases cholesterol levels in people with diabetes

Inflammatory processes in the liver lead to elevated cholesterol levels in people with diabetes, thus promoting subsequent vascular diseases. This is the result of a study by scientists of Helmholtz Zentrum München, Technische Universität München and the Collaborative Research Center SFB 1118 at Heidelberg University Hospital.

14 Aug 2017

Newly discovered biomarker linked to rare metabolic disorders may facilitate better diagnosis

A newly discovered biomarker associated with a rare metabolic disorder may facilitate better diagnosis and identification of new drugs for clinical trials for the disease, according to researchers in the Perelman School of Medicine at the University of Pennsylvania.

7 Aug 2017