Transcription News and Research

RSS

The heart can heal itself

World Congress of Cardiology Report - Despite the dramatic advances in the care of patients with cardiovascular diseases that have occurred in the second half of the 20th century, heart failure (HF) is the most common cause of death in developed nations.

5 Sep 2006

Disabling carbohydrate trigger reduces obesity and appetite

Until about 15 years ago, insulin was believed primarily responsible for turning carbohydrates into fat. But then it became apparent that diet alone could stimulate glucose metabolism and fat synthesis, even when insulin levels were low or absent.

30 Aug 2006

New novel protein-genome interaction mapping technology

Fred Hutchinson Cancer Research Center, The Netherlands Cancer Institute (NKI) and Cancer Research Technology Limited (CRT) today have released details of the development and commercialisation of a powerful protein-genome interaction mapping technology termed 'DamID.'

14 Aug 2006

DNA overwinds when stretched

Most of us are familiar with the winding staircase image of DNA, the repository of a biological cell's genetic information. But few of us realize just how tightly that famous double helix is wound.

8 Aug 2006

New research may solve problem of vessels re-closing after angioplasty

Through studying pigeons with genetic heart disease, researchers at Wake Forest University School of Medicine have discovered a clue about why some patients' heart vessels are prone to close back up after angioplasty.

6 Aug 2006

Researchers determine structure of an important smallpox virus enzyme and how it binds to DNA

Researchers at the University of Pennsylvania School of Medicine have determined the structure of an important smallpox virus enzyme and how it binds to DNA.

4 Aug 2006

Genetic mutations may be responsible for schizophrenia

The higher risk of schizophrenia among offspring of expectant mothers living through famine could help us understand the genetic basis for that debilitating mental disorder.

2 Aug 2006

Gene variant increases risk of type 2 diabetes - but healthy lifestyle changes reduce genetic risk

Researchers have confirmed that a gene variant confers susceptibility to type 2 diabetes in participants of the Diabetes Prevention Program (DPP), a large clinical trial in adults at increased risk for developing type 2 diabetes.

21 Jul 2006

New role discovered for breast cancer susceptibility gene BRCA1

A recently discovered facet of the breast cancer susceptibility gene BRCA1 reveals a mechanism linking mutation of BRCA1 to formation of large blood vessels needed to support cancer progression.

18 Jul 2006

FoxM1 regulates the expression of oestrogen receptors in breast cancer

Research just published online in the "Journal of Biological Chemistry" identifies a new molecule involved in the regulation of oestrogen receptors (ER) expression in breast cancer.

12 Jul 2006

From DNA to RNA to protein

Of the thousands of proteins produced in our cells, few are as important as the enzyme RNA polymerase (RNAP), which has the unique ability to faithfully copy genetic information from DNA.

18 Jun 2006

Transcription factors act not only in isolation to regulate distinct sets of genes

Scientists eager to help develop a new generation of pharmaceuticals are studying cellular proteins called transcription factors, which bind to upstream sequences of genes to turn the expression of those genes on or off.

18 Jun 2006

Researchers identify new keys to regulation of bacterial gene expression

The cellular process of transcription, in which the enzyme RNA polymerase constructs chains of RNA from information contained in DNA, depends upon previously underappreciated sections of both the DNA promoter region and RNA polymerase

18 Jun 2006

Scientists watch the behavior of a single gene in real time

Scientists at the Albert Einstein College of Medicine of Yeshiva University have observed for the first time that gene expression can occur in the form of discrete "pulses" of gene activity.

14 Jun 2006

Protein called Elk-1appears to play role in neurodegeneration and schizophrenia

Pprotein called Elk-1 interacts with mitochondria, the energy storehouse of a cell, suggesting that this protein - typically active in the nucleus - could play a role in cell death and mitochondria-related diseases such as neurodegeneration and schizophrenia.

9 Jun 2006