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Clinical study seeks to examine new combination therapy for treating AML patients

A pair of drugs that may be a one-two punch needed to help combat acute myeloid leukemia (AML), an aggressive blood cancer that kills nearly three-fourths of patients within five years of diagnosis, is the focus of a new multi-center clinical trial that will enroll patients at three sites across the U.S.

7 Mar 2017

Scientists propose rejuvenating bone marrow stem cell niche to boost immunity, fend off cancers

As people get older so do the hematopoietic stem cells (HSCs) that form their blood, creating an increased risk for compromised immunity and certain blood cancers. Now researchers are reporting in the scientific journal that the bone marrow niche where HSC's form also ages, contributing to the problem.

3 Mar 2017

Combination of epigenetic and immune-based treatments could lead to better blood cancer therapies

Researchers at Monash University and Peter MacCallum Cancer Centre have identified for the first time how a new class of epigenetic drug engages with the immune system to kill off cancer cells, offering powerful new pathways for enhanced blood cancer therapies.

1 Mar 2017

Scientists identify potential therapeutic target for aggressive lymphomas

Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III have identified a possible therapeutic target for 2 types of very aggressive lymphomas.

28 Feb 2017

Scientists reveal how gluten plays role in development of rare form of cancer for coeliac patients

Scientists in The Netherlands have revealed how gluten plays a role in the development of a rare form of cancer, for some people with coeliac disease.

27 Feb 2017

Treating multiple myeloma with rabbit virus eliminates majority of malignant cells, study shows

Treating multiple myeloma (MM) with myxoma virus (MYXV) eliminated a majority of malignant cells in preclinical studies, report investigators at the Medical University of South Carolina and elsewhere in an article published online on December 7, 2016 by Molecular Therapy -- Oncolytics.

22 Feb 2017

Researchers examine risk factors for B Cell Non-Hodgkin Lymphoma in Israeli, Palestinian populations

Israeli and Palestinian researchers have conducted a large scale epidemiological study examining risk factors for a form of Non-Hodgkin Lymphoma in these two populations.

21 Feb 2017

Researchers create novel model that reveals cellular, molecular events driving leukemia progression

Mount Sinai researchers have created a novel model that shows the step-by-step progression from normal blood cells to leukemia and its precursor diseases, creating replicas of the stages of the disease to test the efficacy of therapeutic interventions at each stage, according to a study to be published in Cell Stem Cell.

16 Feb 2017

New ‘MAGIC algorithm’ can predict transplant patient’s risk of developing graft-versus-host disease

Researchers at Mount Sinai Health System have discovered a way to predict whether blood cancer patients who received a bone marrow transplant will develop graft-versus-host disease, a common and often lethal complication, according to a study published in JCI Insight.

9 Feb 2017

Autologous hematopoietic cell transplant may induce sustained remission of multiple sclerosis

New clinical trial results provide evidence that high-dose immunosuppressive therapy followed by transplantation of a person's own blood-forming stem cells can induce sustained remission of relapsing-remitting multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system.

2 Feb 2017

Researchers design antibody that recognizes and destroys blood cancer stem cells

A protein-sugar molecule, CD99, occurs more frequently than normal on stem cells responsible for blood cancers, including acute myeloid leukemia (AML) and the related myelodysplastic syndromes.

25 Jan 2017

BRCA1 gene required for survival of blood forming stem cells, UT Southwestern study finds

Researchers at from the Harold C. Simmons Comprehensive Cancer Center have found that the BRCA1 gene is required for the survival of blood forming stem cells, which could explain why patients with BRCA1 mutations do not have an elevated risk for leukemia.

25 Jan 2017

Knowledge bank approach could help find best treatment option for AML patients

An international collaboration led by clinical researchers at the Wellcome Trust Sanger Institute has shown proof-of-concept that truly personalised therapy will be possible in the future for people with cancer.

17 Jan 2017

Inhibition of EZH2 protein could be new strategy to treat multiple myeloma

In a study published in the scientific journal Oncotarget, researchers from Uppsala University show how the protein EZH2 affects the development of multiple myeloma, and that inhibition of EZH2 could be used as a new strategy to treat the disease.

12 Jan 2017

Scientists find new treatment option for rare autoimmune disease

Anti-NMDA receptor encephalitis is an inflammatory disease that affects the central nervous system.

6 Jan 2017

Study shows promising results for treating lymphoma patients with immune cell therapy

Lymphoma is the most common blood cancer. The disease occurs when immune cells called lymphocytes multiply uncontrollably. Cancerous lymphocytes can travel throughout the body and form lymph node tumors.

6 Jan 2017

Researchers identify possible treatment targets for myelodysplasia syndromes

Cincinnati Children's researchers report in Nature Immunology a new mechanism that controls blood cell function and several possible molecular targets for treating myelodysplasia syndromes (MDS) - a group of pre-malignant disorders in which bone marrow does not produce enough healthy blood cells.

30 Dec 2016