Splicing News and Research

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Deadly genetic disease prevented before birth in zebrafish with genetic patch

By injecting a customized "genetic patch" into early stage fish embryos, researchers at Washington University School of Medicine in St. Louis were able to correct a genetic mutation so the embryos developed normally.

24 Mar 2008

Jivan Biologics awarded US patent for splice array analysis

Jivan Biologics Inc., a privately held corporation located in Berkeley, CA, has been awarded US Patent #7,340,349, "Method and System for Identifying Splice Variants of a Gene."

10 Mar 2008

Mutation in TDP-43 gene may play role in common dementia

Scientists at Washington University School of Medicine in St. Louis have linked a mutation in a gene known as TDP-43 to an inherited form of amyotrophic lateral sclerosis (ALS), the neurodegenerative condition often called Lou Gehrig's disease.

21 Feb 2008

Minute genetic differences have major consequences

A study led by McGill University researchers has demonstrated that small differences between individuals at the DNA level can lead to dramatic differences in the way genes produce proteins.

21 Jan 2008

New understanding of cell's inner workings

A group of scientists in Princeton's Department of Ecology and Evolutionary Biology has uncovered a new biological mechanism that could provide a clearer window into a cell's inner workings.

7 Jan 2008

RNA interference therapy heals growth deficiency disorder in a live animal

A team of Vanderbilt researchers have demonstrated for the first time that a new type of gene therapy, called RNA interference, can heal a genetic disorder in a live animal.

20 Dec 2007

Discovery of molecular signal that helps muscle regenerate and protects it from atrophy

It does not take much to injure a muscle. Sometimes one sudden, inconsiderate movement does the job.

20 Dec 2007

Surprising findings related to myotonic muscular dystrophy and heart protein

New research from the University of Virginia Health System shows that, in cases of Type 1 myotonic muscular dystrophy (DM1), a well known heart protein does several surprising things.

18 Dec 2007

New findings on myotonic muscular dystrophy

New research from the University of Virginia Health System shows that, in cases of Type 1 myotonic muscular dystrophy (DM1), a well known heart protein does several surprising things. DM1 is the most common form of muscular dystrophy in adults and affects approximately 40,000 adults and children in the U.S.

18 Dec 2007

Evolution with a restricted number of genes

The development of higher forms of life would appear to have been influenced by RNA polymerase II.

17 Dec 2007

Gene splicing in humans and chimps explains differences

Researchers are closer to understanding why humans differ so greatly from chimpanzees in the way they look, behave, think, and fight off disease, despite having genes that are nearly 99% identical.

15 Nov 2007

Osteopontin-c is a good biomarker of breast cancer.

Researchers have identified a molecule that may be more accurate than existing biological signposts used to predict which breast cancers will develop into advanced forms of the disease.

6 Nov 2007

RNA-binding protein key to understanding myotonic dystrophy type 1

Increased levels of a protein called CUGBP1 play an important role in the adult-onset form of muscular dystrophy called myotonic dystrophy type 1, said Baylor College of Medicine researchers in a report that appears in the journal Molecular Cell.

12 Oct 2007

Loss of TDP-43 gene found to be related to age-related neurological disorders

Researchers at Mayo Clinic in Jacksonville have discovered how loss of a gene can lead to accumulation of toxic proteins in the brain, resulting in a common dementia, and they say this mechanism may be important in a number of age-related neurological disorders.

27 Sep 2007

Scientists describe a new way of creating novel enzymes

The intricate interplay of proteins and other chemicals that underlies most biological activities requires the participation of enzymes, specialized molecules that accelerate chemical reactions between molecules.

17 Aug 2007

Gene mutation linked to cognition is found only in humans

The human and chimpanzee genomes vary by just 1.2 percent, yet there is a considerable difference in the mental and linguistic capabilities between the two species.

9 May 2007

New target for diagnosis and treatment of ovarian cancer

An RNA-binding protein that is overproduced in ovarian cancer may present a new target for diagnosis or treatment of ovarian and other cancers, according to researchers at the University of Illinois at Chicago.

10 Apr 2007

Research helps explain origin of self-reactive B cells

Doctors have long wondered why, in some people, the immune system turns against parts of the body it is designed to protect, leading to autoimmune disease.

7 Feb 2007

Self-assembling nanostructures of DNA

Wouldn't it be great if we could get computer chips to grow on trees? Or at least use the specific bonds of DNA molecules to get nanostructures to grow themselves right in the test tube?

5 Feb 2007

Study extends the number of antigenic peptides that can be produced from a single protein

Understanding medical research problems often relies on the direct, linear relationship between the sequence of a protein and the DNA encoding that protein. In fact, colinearity of DNA and protein sequences is thought to be a fundamental feature of the universal genetic code.

13 Sep 2006