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MDC scientists find solution to increase efficiency of precise genetic modifications

CRISPR-Cas9 is a powerful new tool for editing the genome. For researchers around the world, the CRISPR-Cas9 technique is an exciting innovation because it is faster and cheaper than previous methods. Now, using a molecular trick, Dr. Van Trung Chu and Professor Klaus Rajewsky of the Max Delbrück Center for Molecular Medicine Berlin-Buch and Dr. Ralf Kühn, MDC and Berlin Institute of Health, have found a solution to considerably increase the efficiency of precise genetic modifications by up to eightfold.

30 Mar 2015

3D respiratory tissue model shown to be effective for measuring impact of chemicals

A 3-dimensional model of human respiratory tissue has been shown to be an effective platform for measuring the impact of chemicals, like those found in cigarette smoke, or other aerosols on the lung.

27 Mar 2015

Novo Nordisk announces U.S. launch of Novoeight for people living with hemophilia A

Novo Nordisk today announced the company will launch Novoeight (Antihemophilic Factor [Recombinant]) in the United States for people living with hemophilia A.

From Novo Nordisk 26 Mar 2015

New study reveals how cells sort out loops meant to encode microRNAs

Just as two DNA strands naturally arrange themselves into a helix, DNA's molecular cousin RNA can form hairpin-like loops. But unlike DNA, which has a single job, RNA can play many parts -- including acting as a precursor for small molecules that block the activity of genes. These small RNA molecules must be trimmed from long hairpin-loop structures, raising a question: How do cells know which RNA loops need to be processed this way and which don't?

25 Mar 2015

Study explains why COPD patients develop tolerance to roflumilast drug

Roflumilast, a drug recently approved in the United States to treat severe chronic obstructive pulmonary disease (COPD), increases the production of a protein that causes inflammation, which possibly results in patients developing a tolerance to the drug after repeated use and makes the drug less effective, according to researchers at Georgia State University, Kumamoto University and the University of Rochester Medical Center.

24 Mar 2015

Men who exercise more have better erectile and sexual function

Men who exercise more have better erectile and sexual function, regardless of race, according to a recent study published in the Journal of Sexual Medicine.

24 Mar 2015

Deuterium-containing sigma-1 agonist demonstrates anti-seizure, anti-inflammatory effects in TBI model

Research results published in the Journal of Neurotrauma and conducted by the Walter Reed Army Institute of Research (WRAIR) as part of a collaboration with Concert Pharmaceuticals, Inc. showed that a novel deuterium-containing sigma-1 agonist invented at Concert, called C-10068, demonstrated anti-seizure and anti-inflammatory effects in a preclinical model of traumatic brain injury (TBI).

24 Mar 2015

Home-exercise plan for HIV patients

In addition to antiretroviral medications, people with HIV may soon begin receiving a home exercise plan from their doctors, according to a researcher at Case Western Reserve University's Frances Payne Bolton School of Nursing.

24 Mar 2015

New targeted therapy promises to reduce frequency and intensity of breakouts

Acne, a scourge of adolescence, may be about to meet its ultra high-tech match. By using a combination of ultrasound, gold-covered particles and lasers, researchers from UC Santa Barbara and the private medical device company Sebacia have developed a targeted therapy that could potentially lessen the frequency and intensity of breakouts, relieving acne sufferers the discomfort and stress of dealing with severe and recurring pimples.

23 Mar 2015

EHT expert paper raises important and unanswered questions about safety of wearable tech

Wearable technology is raising health concerns worldwide. A recent New York Times article by Nick Bilton is raising important and unanswered questions about the safety of wearable tech, according to the non-profit research group, Environmental Health Trust.

23 Mar 2015

New diet may significantly lower risk of Alzheimer's disease

A new diet, appropriately known by the acronym MIND, could significantly lower a person's risk of developing Alzheimer's disease, even if the diet is not meticulously followed, according to a paper published online for subscribers in March in the journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

20 Mar 2015

Young children, teens at risk for unintentional medicine poisoning

Nearly half of the 1.34 million calls to poison centers for children each year are related to medicine. In fact, every day, there are more than 1,100 calls about a young child getting into medicine or getting too much medicine.

18 Mar 2015

TSRI scientists successfully test potential preventative therapy for type 1 diabetes in animal models

Scientists from the Florida campus of The Scripps Research Institute have successfully tested a potent synthetic compound that prevents type 1 diabetes in animal models of the disease.

18 Mar 2015

Study tracks long-term effects of weight loss on atrial fibrillation burden

Obese patients with atrial fibrillation who lost at least 10 percent of their body weight were six times more likely to achieve long-term freedom from this common heart rhythm disorder compared to those who did not lose weight, according to a study presented at the American College of Cardiology's 64th Annual Scientific Session.

17 Mar 2015

CT coronary angiography can accurately diagnose coronary artery disease

Use of computed tomography coronary angiography, which provides 3-D images of the heart, coupled with standard care allows doctors to more accurately diagnose coronary artery disease in patients presenting with chest pain, therefore, leading to more appropriate follow-up testing and treatments, according to research presented at the American College of Cardiology's 64th Annual Scientific Session.

17 Mar 2015

Tablet use has implications for potential neck injury

Tablet use has rocketed. Last year in the US, for example, 42% of under 18's owned one and more than half of 35-49 year olds used them regularly.

13 Mar 2015

New study explores patient outcomes one year after TAVR procedure

In an analysis of outcomes of about 12,000 patients who underwent transcatheter aortic valve replacement, death rate after one year was nearly one in four; of those alive at 12 months, almost half had not been rehospitalized and approximately 25 percent had only one hospitalization, according to a study in the March 10 issue of JAMA.

12 Mar 2015

Scientists find strong association between MAIT lymphocytes and metabolic dysfunctions

Scientists at Institut Cochin (CNRS/Inserm/Université Paris Descartes) and ICAN - Institute of Cardiometabolism And NutritionInserm/UPMC/AP-HP) have discovered that a class of inflammatory cells, MAIT lymphocytes1, is deregulated in patients suffering from type 2 diabetes and obesity.

12 Mar 2015

Obstructive sleep apnea increases risk of motor vehicle accidents

A new study finds that obstructive sleep apnea is associated with a significantly increased risk of motor vehicle accidents, and this risk is reduced when sleep apnea is treated effectively using continuous positive airway pressure (CPAP) therapy.

11 Mar 2015

Rare, aggressive subtype of pediatric acute lymphoblastic leukemia has surprisingly few mutations

The St. Jude Children's Research Hospital--Washington University Pediatric Cancer Genome Project reports that a highly aggressive form of leukemia in infants has surprisingly few mutations beyond the chromosomal rearrangement that affects the MLL gene. The findings suggest that targeting the alteration is likely the key to improved survival.

9 Mar 2015

Frequency News and Research

MDC scientists find solution to increase efficiency of precise genetic modifications

3D respiratory tissue model shown to be effective for measuring impact of chemicals

Novo Nordisk announces U.S. launch of Novoeight for people living with hemophilia A

New study reveals how cells sort out loops meant to encode microRNAs

Study explains why COPD patients develop tolerance to roflumilast drug

Men who exercise more have better erectile and sexual function

Deuterium-containing sigma-1 agonist demonstrates anti-seizure, anti-inflammatory effects in TBI model

Home-exercise plan for HIV patients

New targeted therapy promises to reduce frequency and intensity of breakouts

EHT expert paper raises important and unanswered questions about safety of wearable tech

New diet may significantly lower risk of Alzheimer's disease

Young children, teens at risk for unintentional medicine poisoning

TSRI scientists successfully test potential preventative therapy for type 1 diabetes in animal models

Study tracks long-term effects of weight loss on atrial fibrillation burden

CT coronary angiography can accurately diagnose coronary artery disease

Tablet use has implications for potential neck injury

New study explores patient outcomes one year after TAVR procedure

Scientists find strong association between MAIT lymphocytes and metabolic dysfunctions

Obstructive sleep apnea increases risk of motor vehicle accidents

Rare, aggressive subtype of pediatric acute lymphoblastic leukemia has surprisingly few mutations

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