Threonine News and Research

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Mice live longer with nasal gene therapy

In a recent study published in the Proceedings of the National Academy of Sciences journal, researchers assessed the efficiency of a novel intranasal and injectable therapy in improving life expectancy.

17 May 2022

ST6Gal-I–mediated sialylation of the EGFR modulates cell mechanics and enhances cancer invasion

For more than two decades, University of Alabama at Birmingham researcher Susan Bellis, Ph.D., has studied how the addition of sialic acid to various proteins increases cancer resistance and oncogenicity.

22 Apr 2022

Study investigates co-metabolism during SARS-CoV-2 infection

In a new study, researchers investigated host-virus co-metabolism during a SARS-CoV-2 infection.

20 Apr 2022

New, longest documented case of persistent acute SARS-CoV-2 infection

Researchers describe a 16-month-old case of SARS-CoV-2 infection in an immunocompromised individual.

18 Apr 2022

Exploring evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates

Researchers performed high-throughput evolutionary analyses of genes encoding 334 SARS-CoV-2 viral-interacting proteins of modern humans, primates, and bats.

11 Apr 2022

Study shows potential inhibition of SARS-CoV-2 main protease by natural phytochemicals

A new study assessed the molecular dynamics of potentially active natural phytochemicals to target the SARS-CoV-2 main protease.

29 Mar 2022

Algal metabolites as novel drugs against viruses

A new review article published in the Journal of Biotechnology has provided information on various nutraceutical metabolites extracted from algae.

29 Mar 2022

Importance of Numb-associated kinases in SARS-CoV-2 infection

A new study posted to the bioRxiv* preprint server has focussed on assessing four members of the NAK family that are associated with SARS-CoV-2 infection. These kininases could act as a target for the development of effective COVID-19 therapeutics.

23 Mar 2022

Study reveals novel tumor biomarker of aggressive cancers with poor prognosis

A study published in The Journal of Pathology reveals that many cancers that carry a poor prognosis express an altered form of human telomerase reverse transcriptase (hTERT), an enzyme that regulates the expression of multiple genes.

22 Mar 2022

Glycogen synthase kinase-3 inhibitors found to attenuate COVID-19-associated cytokine storm

In a new study, researchers investigated whether the SARS-CoV-2 spike protein and its S2 subunit induced the expression of C–X–C motif chemokine 10, a subset of cytokine.

21 Mar 2022

Could oropharyngeal microflora predict COVID-19 patients' need for respiratory support?

Researchers identify oropharyngeal bacteria and metabolic pathways that are predictive of the need for respiratory support in COVID-19 patients.

7 Mar 2022

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

Researchers used deep mutational scans to measure the effect of each amino-acid mutation in the receptor-binding domain of SARS-CoV-2 Wuhan-Hu-1, Alpha, Beta, Delta, and Eta variants.

1 Mar 2022

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Researchers investigated the connecting link between viral genetic variability and clinical heterogeneity of COVID-19 by analyzing the effect of several missense mutations on the ACE2 receptor coding sequence.

18 Feb 2022

Genetic marker linked to higher risk of death in COVID-19 patients

A new study discusses the importance of single nucleotide polymorphisms in the Rab46 gene as a marker of adverse outcomes in high-risk COVID-19 patients.

23 Jan 2022

Host kinase identified as an inhibition target for SARS-CoV-2

In this experiment, the chemical probe SGC-CK2-1 inhibited virus replication at nanomolar concentration, showing a highly selective effect on the kinase.

6 Jan 2022

Boceprevir-based molecules show high antiviral potency against SARS-CoV-2

In a study posted to the bioRxiv* pre-print server, a team of researchers conducted a structure-activity relationship study of boceprevir-based molecules to find antiviral drug candidates targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protease MPro.

22 Dec 2021

Threonine News and Research

Mice live longer with nasal gene therapy

ST6Gal-I–mediated sialylation of the EGFR modulates cell mechanics and enhances cancer invasion

Study investigates co-metabolism during SARS-CoV-2 infection

New, longest documented case of persistent acute SARS-CoV-2 infection

Exploring evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates

Study shows potential inhibition of SARS-CoV-2 main protease by natural phytochemicals

Algal metabolites as novel drugs against viruses

Importance of Numb-associated kinases in SARS-CoV-2 infection

Study reveals novel tumor biomarker of aggressive cancers with poor prognosis

Glycogen synthase kinase-3 inhibitors found to attenuate COVID-19-associated cytokine storm

Could oropharyngeal microflora predict COVID-19 patients' need for respiratory support?

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

Impact of several ACE2 coding missense variants and their effect on ACE2 protein subcellular localization and trafficking

Genetic marker linked to higher risk of death in COVID-19 patients

Host kinase identified as an inhibition target for SARS-CoV-2

Boceprevir-based molecules show high antiviral potency against SARS-CoV-2

SARS-CoV-2 infection leads to distinct changes in proteomic and peptidomic profiles and posttranslational modifications

Comparison of RBD/ACE2 receptor complex in wild type SARS-CoV-2 and Omicron variant

Bioinformatics pipeline can be used to quickly identify SARS-CoV-2 therapeutics

The emergence and evolution of SARS-CoV-2 and its VOCs

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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